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The map label for this gene is yjl094C [H]

Identifier: 21241028

GI number: 21241028

Start: 302045

End: 303304

Strand: Reverse

Name: yjl094C [H]

Synonym: XAC0254

Alternate gene names: 21241028

Gene position: 303304-302045 (Counterclockwise)

Preceding gene: 21241029

Following gene: 21241027

Centisome position: 5.86

GC content: 67.46

Gene sequence:

>1260_bases
ATGAATCAAACCACGTTGTTGCTGGTGCAGTTGGCGGTGATCCTGGGCGCTGCGCGCCTGTGCGGTGCGTTGTTGCAACG
CATTGGGCAGCCGCCGGTCATCGGCGAAATGGCGGCCGGGCTGTTGCTCGGTCCGATCGCATTCGGTGCCTGGCTGCCCG
ACCTGCACACGGCGTTGTTCGCCGCCAAAACCCTGCCGCCGCTGTCCGGCCTGGCCACGATGGGCGTGGTGCTTTTCATG
TTCGTGGTCGGCGTGGAATTGCGTGCGCCGGAAGGCACCAAGACGCAAGTGCGTGCCTCGGTCCTGGTGGGCGTGGCCGG
CATCGTGTTGCCGCTGCTGCTCGGTCTGGCTGCCGCGCCGTGGCTGTTCCCGCGCTTCGCACCGCAAGGCGTCAGCTTCT
GGCCGTTCGCGCTGTTCATTGCCGCGGCGATGTCGGTGACGGCATTTCCGGTGCTGGCACGCATCCTCAAGGACCGCAAC
ATGACGCGGACGCCGGCCGGCCGCCTGGCGCTGGGCGCGGCCGTGATCGACGATGCCACGGTATGGATCTTCCTGGCGAT
CGTGCTGACCCTGACCGGCAACAACGCGCATGGCGGTGTGGCGTTCACGGCCATCGGTGCGTTGGTCCTGATCGCCGGCG
TGTTCGGTGTGCTCAAGCCTGCCTATGCGCGCCTGCTGCGCTCCCGCGCGCATGACGGCCGGTATGCACCGAGCGCGCTG
GTATGGGCGTTGATCGGGCTGCTGGCATGCGCCGCGCTGGCGGAGTGGATCGGGCTGCATGCGATCTTTGGCGCCTTCCT
GTTCGGCATCTGCCTGCCGCGCGATGACCGCCTGCTGGAGCATCTGGCCGGGCGCATCGAGCCGCTGGCCATCACCTTGC
TGATGCCGGTGCTGTTCGCCGTTGCCGGTCAAGCCACCAGCCCTGGCGCGTTCGCCGGCGCCGGCCTGAGCGGACTTGTG
CTGGTGATCGGCATGGCGGTGAGCGGCAAGTTGCTCGGCTGCACGCTGGGTGCGCGCCTGAGCGGCCATCGATGGCGCGA
CAGTCTCACCGTGGGCTCGCTGATGAACGCACGCGGGCTGATGGAGTTGGTGGTGATCAAGATCGGACTGGATAGCGGCG
TGATCGGGCCGGATCTGTTTACGCTGTTGTTCGGCATGACGCTGGTGACCACGGTGATGGCGTCGCCGATGGTGGCCTGG
TTCCAGGGCAGGCGGCACGCAGCGGCCGATGCGCTGGCCGCAAGCAACTCGCCTCACTGA

Upstream 100 bases:

>100_bases
GCGCATGCGGCGCATCGCTGTGCCGTCGGTCTGGGGGAACTGGCCGATGACCTGCAGGACGCGAGGGCCGAGCCGACTCA
ACCACTGGAATGCTGAGGCG

Downstream 100 bases:

>100_bases
TGAGGGCGCGATGGTGCTGCGGTGCCGCGTCAGGCCGGATACCGTGCATGCAACTGCGCTGCGGCCGAGCGCATGGCGTT
GGATCACCGCGCGCTCGAGG

Product: Na+/H+-exchanging protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNQTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHTALFAAKTLPPLSGLATMGVVLFM
FVVGVELRAPEGTKTQVRASVLVGVAGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAGVFGVLKPAYARLLRSRAHDGRYAPSAL
VWALIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGMAVSGKLLGCTLGARLSGHRWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQGRRHAAADALAASNSPH

Sequences:

>Translated_419_residues
MNQTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHTALFAAKTLPPLSGLATMGVVLFM
FVVGVELRAPEGTKTQVRASVLVGVAGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAGVFGVLKPAYARLLRSRAHDGRYAPSAL
VWALIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGMAVSGKLLGCTLGARLSGHRWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQGRRHAAADALAASNSPH
>Mature_419_residues
MNQTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHTALFAAKTLPPLSGLATMGVVLFM
FVVGVELRAPEGTKTQVRASVLVGVAGIVLPLLLGLAAAPWLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRN
MTRTPAGRLALGAAVIDDATVWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAGVFGVLKPAYARLLRSRAHDGRYAPSAL
VWALIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFAVAGQATSPGAFAGAGLSGLV
LVIGMAVSGKLLGCTLGARLSGHRWRDSLTVGSLMNARGLMELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAW
FQGRRHAAADALAASNSPH

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=405, Percent_Identity=33.0864197530864, Blast_Score=194, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43556; Mature: 43556

Theoretical pI: Translated: 10.79; Mature: 10.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHTALF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKTLPPLSGLATMGVVLFMFVVGVELRAPEGTKTQVRASVLVGVAGIVLPLLLGLAAAP
HHHCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRNMTRTPAGRLALGAAVIDDAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAGVFGVLKPAYARLLRSRAHDGRYAPSAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
VWALIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGQATSPGAFAGAGLSGLVLVIGMAVSGKLLGCTLGARLSGHRWRDSLTVGSLMNARGL
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHH
MELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAWFQGRRHAAADALAASNSPH
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNQTTLLLVQLAVILGAARLCGALLQRIGQPPVIGEMAAGLLLGPIAFGAWLPDLHTALF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKTLPPLSGLATMGVVLFMFVVGVELRAPEGTKTQVRASVLVGVAGIVLPLLLGLAAAP
HHHCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLFPRFAPQGVSFWPFALFIAAAMSVTAFPVLARILKDRNMTRTPAGRLALGAAVIDDAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
VWIFLAIVLTLTGNNAHGGVAFTAIGALVLIAGVFGVLKPAYARLLRSRAHDGRYAPSAL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
VWALIGLLACAALAEWIGLHAIFGAFLFGICLPRDDRLLEHLAGRIEPLAITLLMPVLFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
VAGQATSPGAFAGAGLSGLVLVIGMAVSGKLLGCTLGARLSGHRWRDSLTVGSLMNARGL
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHH
MELVVIKIGLDSGVIGPDLFTLLFGMTLVTTVMASPMVAWFQGRRHAAADALAASNSPH
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]