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The map label for this gene is 21226800

Identifier: 21226800

GI number: 21226800

Start: 838235

End: 839716

Strand: Direct

Name: 21226800

Synonym: MM_0698

Alternate gene names: NA

Gene position: 838235-839716 (Clockwise)

Preceding gene: 21226799

Following gene: 21226801

Centisome position: 20.46

GC content: 47.5

Gene sequence:

>1482_bases
ATGGAAATTTTGATTGCAACAGGGCGGCTTGCGGAAAATACCGTGAGAAAAGCGGCTGGAGAAAAAGCAGACGTCCTTGT
AGCAGATATCGACATTGCTGCCTTTATCACCCCGAAAAAACTTACCAGAGCCTTTGAGGAAGCCGGATTATCAAAAAAAT
ATGACCTCATTCTGCTTCCCGGACTTGTACCGGGTGATTTTTCAAAGGTATCGGACGAGCTTGACTGTAAAATCCGGCTG
GGCCCTAAACATGCTTATGACCTTGGCTTTGTGCTCCGTTTTGCAGAAGAAGTGGAGTTTTCCGTAAAGGTCCCTGCCTG
TGAGCTCCTTGCAGACGTAAGAAAGGAAGAAGCTCTTGAGCTTATAAGAGAAGCCGAAGAAGAAGCCGTTTCTCCACTTA
GCCTGAGAGGAGTAAAACTGGGAGGAAACTCCCGAATGAAAGTTATGGGAGAGATTGTAGGAGCAGCCGAGTTGAACCCT
GCTGACCTGGAGATAAAAATCGAAGCTTTTATCGCCCGTGGAGCAGATATTATCGACCTCGGAGCTACACTTAACACCCT
TCCGGGACAGGTCCGAAGTACGGTATTCCTTGCAAAATCTCTCACAGATATTCCGATAAGTATAGATACCCTTGACCCTG
AGCTGATAAAGGAAGGAATAGAAGCAGGAGCAGACCTTGTTCTGAGCCTTAACAGCACAAATATGGAAACAGCAGGCTCC
GTGGTTGCAAAAGCAGGTGTTGCAGCAGTCATAATTCCTGATGAAGGAAACAGTCTGGAAAGCCTTGTAAATAATATCGA
ATCCGCACGCAGGCTCGGGATTGAAAGAATTATAGCCGACCCTATCCTTGACCCTGTAGGCCATAATATAACGGAATCCA
TTGTTCGCTACCATGAGTTTCACAGGAGATATCCTGACATTCCATTATTCTTTGGGGCAGGCAATGTAACCGAACTCATG
GACGTGGATACGATAGGAGTAAATGCCACACTCTGCGGAATAGGAGCCGAAACCGGGGCAAGTATCCTTTTTACCCCCGA
GTACAGCGATAAAGCCCAGGGCTCCATAGGAGAGCTGAAAAAAGCCTCTGAGATGATGCAGCTTTGCAGGATAAGGGAAA
GCTCCCCCAAGGATCTTGGCATTGACCTCCTCTTCATAAAGGAAAAACGAAAACGCCCTGACAGCCCCCTCCCCAAAAAA
GTGATTACTGCCAGAGCTTCGAAAAACTGGCGTCAGGACCCTGCAGGCCCAATAAGAGTCAGGATTGTGCCGGATAAAAT
TAACGGAAATGGCGGACTCATTGTAGCCGAACATGAGAAAGCAGCAATTGCAGGAGAAAGCGCCAGGGAAGTTATGGATA
CATTGATTGAACTCGAACTGGTCTCGAGCCTGGATCACGCTGCATATCTTGGAAGAGAACTGGAAAAAGCCGAACTTGCT
CTGCGCTTCAACCGGAGTTACGCCCAGGACGATATATTTTGA

Upstream 100 bases:

>100_bases
TCCTCGGAGCGGAAAGTTAGAGTTTTCCTGACCGGGAAGCTATTTTTTGAGGCAGCTACAGATAGATACTCTTTTTTATT
AGCTATTCTATCTAAAAAAC

Downstream 100 bases:

>100_bases
ATACCGGAAAGCAGGCAAAAAAAGGAGATGTGAGAAAATGAAACTGGAGAATGAAGATAAACAGTCAATCTTTGAGATAG
TGGCAGGCCGCTATTTCACG

Product: dihydropteroate synthase

Products: diphosphate; dihydropteroate

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MEILIATGRLAENTVRKAAGEKADVLVADIDIAAFITPKKLTRAFEEAGLSKKYDLILLPGLVPGDFSKVSDELDCKIRL
GPKHAYDLGFVLRFAEEVEFSVKVPACELLADVRKEEALELIREAEEEAVSPLSLRGVKLGGNSRMKVMGEIVGAAELNP
ADLEIKIEAFIARGADIIDLGATLNTLPGQVRSTVFLAKSLTDIPISIDTLDPELIKEGIEAGADLVLSLNSTNMETAGS
VVAKAGVAAVIIPDEGNSLESLVNNIESARRLGIERIIADPILDPVGHNITESIVRYHEFHRRYPDIPLFFGAGNVTELM
DVDTIGVNATLCGIGAETGASILFTPEYSDKAQGSIGELKKASEMMQLCRIRESSPKDLGIDLLFIKEKRKRPDSPLPKK
VITARASKNWRQDPAGPIRVRIVPDKINGNGGLIVAEHEKAAIAGESAREVMDTLIELELVSSLDHAAYLGRELEKAELA
LRFNRSYAQDDIF

Sequences:

>Translated_493_residues
MEILIATGRLAENTVRKAAGEKADVLVADIDIAAFITPKKLTRAFEEAGLSKKYDLILLPGLVPGDFSKVSDELDCKIRL
GPKHAYDLGFVLRFAEEVEFSVKVPACELLADVRKEEALELIREAEEEAVSPLSLRGVKLGGNSRMKVMGEIVGAAELNP
ADLEIKIEAFIARGADIIDLGATLNTLPGQVRSTVFLAKSLTDIPISIDTLDPELIKEGIEAGADLVLSLNSTNMETAGS
VVAKAGVAAVIIPDEGNSLESLVNNIESARRLGIERIIADPILDPVGHNITESIVRYHEFHRRYPDIPLFFGAGNVTELM
DVDTIGVNATLCGIGAETGASILFTPEYSDKAQGSIGELKKASEMMQLCRIRESSPKDLGIDLLFIKEKRKRPDSPLPKK
VITARASKNWRQDPAGPIRVRIVPDKINGNGGLIVAEHEKAAIAGESAREVMDTLIELELVSSLDHAAYLGRELEKAELA
LRFNRSYAQDDIF
>Mature_493_residues
MEILIATGRLAENTVRKAAGEKADVLVADIDIAAFITPKKLTRAFEEAGLSKKYDLILLPGLVPGDFSKVSDELDCKIRL
GPKHAYDLGFVLRFAEEVEFSVKVPACELLADVRKEEALELIREAEEEAVSPLSLRGVKLGGNSRMKVMGEIVGAAELNP
ADLEIKIEAFIARGADIIDLGATLNTLPGQVRSTVFLAKSLTDIPISIDTLDPELIKEGIEAGADLVLSLNSTNMETAGS
VVAKAGVAAVIIPDEGNSLESLVNNIESARRLGIERIIADPILDPVGHNITESIVRYHEFHRRYPDIPLFFGAGNVTELM
DVDTIGVNATLCGIGAETGASILFTPEYSDKAQGSIGELKKASEMMQLCRIRESSPKDLGIDLLFIKEKRKRPDSPLPKK
VITARASKNWRQDPAGPIRVRIVPDKINGNGGLIVAEHEKAAIAGESAREVMDTLIELELVSSLDHAAYLGRELEKAELA
LRFNRSYAQDDIF

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: 2.5.1.15

Molecular weight: Translated: 53464; Mature: 53464

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILIATGRLAENTVRKAAGEKADVLVADIDIAAFITPKKLTRAFEEAGLSKKYDLILLP
CEEEEECCCHHHHHHHHHCCCCCCEEEEEECEEEEECHHHHHHHHHHCCCCCCCCEEEEC
GLVPGDFSKVSDELDCKIRLGPKHAYDLGFVLRFAEEVEFSVKVPACELLADVRKEEALE
CCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHH
LIREAEEEAVSPLSLRGVKLGGNSRMKVMGEIVGAAELNPADLEIKIEAFIARGADIIDL
HHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEC
GATLNTLPGQVRSTVFLAKSLTDIPISIDTLDPELIKEGIEAGADLVLSLNSTNMETAGS
CCCHHCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHH
VVAKAGVAAVIIPDEGNSLESLVNNIESARRLGIERIIADPILDPVGHNITESIVRYHEF
HHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
HRRYPDIPLFFGAGNVTELMDVDTIGVNATLCGIGAETGASILFTPEYSDKAQGSIGELK
HHHCCCCEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHH
KASEMMQLCRIRESSPKDLGIDLLFIKEKRKRPDSPLPKKVITARASKNWRQDPAGPIRV
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEE
RIVPDKINGNGGLIVAEHEKAAIAGESAREVMDTLIELELVSSLDHAAYLGRELEKAELA
EEEECEECCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRFNRSYAQDDIF
EEECCCCCCCCCC
>Mature Secondary Structure
MEILIATGRLAENTVRKAAGEKADVLVADIDIAAFITPKKLTRAFEEAGLSKKYDLILLP
CEEEEECCCHHHHHHHHHCCCCCCEEEEEECEEEEECHHHHHHHHHHCCCCCCCCEEEEC
GLVPGDFSKVSDELDCKIRLGPKHAYDLGFVLRFAEEVEFSVKVPACELLADVRKEEALE
CCCCCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHH
LIREAEEEAVSPLSLRGVKLGGNSRMKVMGEIVGAAELNPADLEIKIEAFIARGADIIDL
HHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEEC
GATLNTLPGQVRSTVFLAKSLTDIPISIDTLDPELIKEGIEAGADLVLSLNSTNMETAGS
CCCHHCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHH
VVAKAGVAAVIIPDEGNSLESLVNNIESARRLGIERIIADPILDPVGHNITESIVRYHEF
HHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
HRRYPDIPLFFGAGNVTELMDVDTIGVNATLCGIGAETGASILFTPEYSDKAQGSIGELK
HHHCCCCEEEECCCCCHHHHCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHH
KASEMMQLCRIRESSPKDLGIDLLFIKEKRKRPDSPLPKKVITARASKNWRQDPAGPIRV
HHHHHHHHHHHCCCCCCCCCEEEEEEECHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEE
RIVPDKINGNGGLIVAEHEKAAIAGESAREVMDTLIELELVSSLDHAAYLGRELEKAELA
EEEECEECCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRFNRSYAQDDIF
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate; 4-aminobenzoate

Specific reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]