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The map label for this gene is cdhE1

Identifier: 21226791

GI number: 21226791

Start: 826775

End: 828187

Strand: Direct

Name: cdhE1

Synonym: MM_0689

Alternate gene names: 21226791

Gene position: 826775-828187 (Clockwise)

Preceding gene: 21226790

Following gene: 21226792

Centisome position: 20.18

GC content: 46.99

Gene sequence:

>1413_bases
ATGAAGATTAACAGCCCATTAGAAGCGTACAAGTACCTGCCTCAGACCAACTGTGGAGAATGTGGTCAGCCTACATGTAT
GGCATTTGCCTCCACGCTGATCGATAGGTCAGGCAAGACAACAGACTGCCCTCCCCTGATTAAAGAAAAGAAGTTTGCAA
AGAAACTGGCAGAACTAGACAGGCTCCTTGCTCCTGAAATTCGCCAGGTTACTATTGGTGTTGGCGAAAGAGCAGCCAAT
ATTGGTGGAGACGATGTACTGTACCGCCACAAACTGACATTCTTTAACAAGACAAAGATGTTCTTCGATGTGGCAGACAA
CATGGACGAAGCTGCCATTGTTGAAAGAGTGAAGAAGATCAGTGATTACAAGAAGTTCTATGTAGGACGTAACCTGCTTC
TCGATGGTGTGGCAATAAGAGCAGCATCCAATGATCCTGCAAAGTTTGCAACAGCTGTCAAGAAAGTTATAGAAAACACA
GAACTGCCTGTAATTCTATGTTCTTTCAATCCTGCAGTCCTGAAGGCAGGACTTGAGGTAGCAAAGGGTAAAAACCCGCT
GCTGTATGCTGCAAACAAGGACAACTGGAAAGAGGTAGGAGAACTAGCACTCGAGTATAACGTGCCTGTGGTTGTTTCAG
CGTTTAATGACCTTGACGGCCTGAAGACTCTTGCAAAGACATTTGCAGAGGCTGGAATTAAGGACATTGTGCTTGATCCG
GGAACTTACCCAACCGGGAAAGGTCTGAAGGATACTTTCACCAACTTCCTGAAGATCAGGAGAGCAGGCATTATGGGAGA
CACCGAGATCGCGTATCCGATCATGGCTATGCCGCTTACTGCCTGGATGGCGGGAATTGCTGACCCTGTCAGTGCATCAT
ACTGGGAAACTGTTCTTGCATCAATCTTTACTATCAGGTACGGAGACATTATGCTCCTCCACAGCATGGAGCCATATGCC
ACCATGCCAGAAGTACACCTGGCAGAGACAATATACACTGACCCCAGGTCTCCTGTTGCCGTAGACTCAAAGATGTATAA
GGTAGGAAACCCAACAGCAGATTCACCTGTACTCTTTACCACAAACTTCGCCCTTACTTACTACACAGTAGAGAGCGACC
TTGCATCAAACGGAATAGACTGCTGGCTGCTTGCAGTTAACACAGATGGTATTGGTGTGGAAGCAGCGGCTGCAGGTGGA
CAGCTGACAGCTGATAAGGTGAAGGATGCATTTGAGAAGTCAGGATTTGACCTCAAGAGCGATGTTACCCATAACAGTGT
AGTTATTCCGGGTCTTGCCGCCCGTCTACAGGGTGATATTGAGGACAAACTCAATGTAAAAGTTATGGTTGGTCCAATGG
ACTCAGGAAGGCTACCAGGCTGGATGGAGAAGAACTGGCCACCAAAGAAATAA

Upstream 100 bases:

>100_bases
ATCGGTTGCTGTCCTGAAGCAGATTACCCAGACGCTATTCGGTACCATAGACACAGAGCAGGTGGATATTGCAAACTGGA
TCGGAGCGGAGGTGTGAAAA

Downstream 100 bases:

>100_bases
AATAAAGTGAAAAAGACTAATTTAAACCTGAAAGCATCCGTGCTAACCTGCACGGATACTTTACTCTTTTTTAGAACGCA
CTTGAGGGTTTTTATATACA

Product: acetyl-CoA decarbonylase/synthase complex subunit gamma

Products: CO2; AH2

Alternate protein names: ACDS complex subunit gamma 1; ACDS complex methyltransferase 1; Corrinoid/iron-sulfur component large subunit 1

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKINSPLEAYKYLPQTNCGECGQPTCMAFASTLIDRSGKTTDCPPLIKEKKFAKKLAELDRLLAPEIRQVTIGVGERAAN
IGGDDVLYRHKLTFFNKTKMFFDVADNMDEAAIVERVKKISDYKKFYVGRNLLLDGVAIRAASNDPAKFATAVKKVIENT
ELPVILCSFNPAVLKAGLEVAKGKNPLLYAANKDNWKEVGELALEYNVPVVVSAFNDLDGLKTLAKTFAEAGIKDIVLDP
GTYPTGKGLKDTFTNFLKIRRAGIMGDTEIAYPIMAMPLTAWMAGIADPVSASYWETVLASIFTIRYGDIMLLHSMEPYA
TMPEVHLAETIYTDPRSPVAVDSKMYKVGNPTADSPVLFTTNFALTYYTVESDLASNGIDCWLLAVNTDGIGVEAAAAGG
QLTADKVKDAFEKSGFDLKSDVTHNSVVIPGLAARLQGDIEDKLNVKVMVGPMDSGRLPGWMEKNWPPKK

Sequences:

>Translated_470_residues
MKINSPLEAYKYLPQTNCGECGQPTCMAFASTLIDRSGKTTDCPPLIKEKKFAKKLAELDRLLAPEIRQVTIGVGERAAN
IGGDDVLYRHKLTFFNKTKMFFDVADNMDEAAIVERVKKISDYKKFYVGRNLLLDGVAIRAASNDPAKFATAVKKVIENT
ELPVILCSFNPAVLKAGLEVAKGKNPLLYAANKDNWKEVGELALEYNVPVVVSAFNDLDGLKTLAKTFAEAGIKDIVLDP
GTYPTGKGLKDTFTNFLKIRRAGIMGDTEIAYPIMAMPLTAWMAGIADPVSASYWETVLASIFTIRYGDIMLLHSMEPYA
TMPEVHLAETIYTDPRSPVAVDSKMYKVGNPTADSPVLFTTNFALTYYTVESDLASNGIDCWLLAVNTDGIGVEAAAAGG
QLTADKVKDAFEKSGFDLKSDVTHNSVVIPGLAARLQGDIEDKLNVKVMVGPMDSGRLPGWMEKNWPPKK
>Mature_470_residues
MKINSPLEAYKYLPQTNCGECGQPTCMAFASTLIDRSGKTTDCPPLIKEKKFAKKLAELDRLLAPEIRQVTIGVGERAAN
IGGDDVLYRHKLTFFNKTKMFFDVADNMDEAAIVERVKKISDYKKFYVGRNLLLDGVAIRAASNDPAKFATAVKKVIENT
ELPVILCSFNPAVLKAGLEVAKGKNPLLYAANKDNWKEVGELALEYNVPVVVSAFNDLDGLKTLAKTFAEAGIKDIVLDP
GTYPTGKGLKDTFTNFLKIRRAGIMGDTEIAYPIMAMPLTAWMAGIADPVSASYWETVLASIFTIRYGDIMLLHSMEPYA
TMPEVHLAETIYTDPRSPVAVDSKMYKVGNPTADSPVLFTTNFALTYYTVESDLASNGIDCWLLAVNTDGIGVEAAAAGG
QLTADKVKDAFEKSGFDLKSDVTHNSVVIPGLAARLQGDIEDKLNVKVMVGPMDSGRLPGWMEKNWPPKK

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy

COG id: COG1456

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDG1_METMA (Q8PZ09)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632713.1
- ProteinModelPortal:   Q8PZ09
- SMR:   Q8PZ09
- GeneID:   1479031
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0689
- NMPDR:   fig|192952.1.peg.689
- HOGENOM:   HBG304431
- OMA:   YTDPRKP
- ProtClustDB:   PRK04165
- BioCyc:   MMAZ192952:MM0689-MONOMER
- GO:   GO:0015948
- HAMAP:   MF_01136
- InterPro:   IPR016041
- InterPro:   IPR016218
- InterPro:   IPR011005
- InterPro:   IPR007202
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- PIRSF:   PIRSF000376

Pfam domain/function: PF03599 CdhD; PF04060 FeS; SSF51717 DHP_synth_like

EC number: 1.2.99.2

Molecular weight: Translated: 51333; Mature: 51333

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00198 4FE4S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINSPLEAYKYLPQTNCGECGQPTCMAFASTLIDRSGKTTDCPPLIKEKKFAKKLAELD
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RLLAPEIRQVTIGVGERAANIGGDDVLYRHKLTFFNKTKMFFDVADNMDEAAIVERVKKI
HHHCCCHHEEEEECCCHHCCCCCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHH
SDYKKFYVGRNLLLDGVAIRAASNDPAKFATAVKKVIENTELPVILCSFNPAVLKAGLEV
HHHHHHHHCCHHEECCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
AKGKNPLLYAANKDNWKEVGELALEYNVPVVVSAFNDLDGLKTLAKTFAEAGIKDIVLDP
HCCCCCEEEECCCCCHHHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECC
GTYPTGKGLKDTFTNFLKIRRAGIMGDTEIAYPIMAMPLTAWMAGIADPVSASYWETVLA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SIFTIRYGDIMLLHSMEPYATMPEVHLAETIYTDPRSPVAVDSKMYKVGNPTADSPVLFT
HHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEECCCCCCCCCEEEE
TNFALTYYTVESDLASNGIDCWLLAVNTDGIGVEAAAAGGQLTADKVKDAFEKSGFDLKS
EEEEEEEEEEEHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCC
DVTHNSVVIPGLAARLQGDIEDKLNVKVMVGPMDSGRLPGWMEKNWPPKK
CCCCCCEECCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKINSPLEAYKYLPQTNCGECGQPTCMAFASTLIDRSGKTTDCPPLIKEKKFAKKLAELD
CCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RLLAPEIRQVTIGVGERAANIGGDDVLYRHKLTFFNKTKMFFDVADNMDEAAIVERVKKI
HHHCCCHHEEEEECCCHHCCCCCCCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHHHHH
SDYKKFYVGRNLLLDGVAIRAASNDPAKFATAVKKVIENTELPVILCSFNPAVLKAGLEV
HHHHHHHHCCHHEECCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
AKGKNPLLYAANKDNWKEVGELALEYNVPVVVSAFNDLDGLKTLAKTFAEAGIKDIVLDP
HCCCCCEEEECCCCCHHHHHHHHEEECCCEEEEECCCHHHHHHHHHHHHHCCCCEEEECC
GTYPTGKGLKDTFTNFLKIRRAGIMGDTEIAYPIMAMPLTAWMAGIADPVSASYWETVLA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SIFTIRYGDIMLLHSMEPYATMPEVHLAETIYTDPRSPVAVDSKMYKVGNPTADSPVLFT
HHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEECCCCCCCCCEEEE
TNFALTYYTVESDLASNGIDCWLLAVNTDGIGVEAAAAGGQLTADKVKDAFEKSGFDLKS
EEEEEEEEEEEHHHHCCCCEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCC
DVTHNSVVIPGLAARLQGDIEDKLNVKVMVGPMDSGRLPGWMEKNWPPKK
CCCCCCEECCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824