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The map label for this gene is paaK [H]

Identifier: 21226778

GI number: 21226778

Start: 812578

End: 813891

Strand: Direct

Name: paaK [H]

Synonym: MM_0676

Alternate gene names: 21226778

Gene position: 812578-813891 (Clockwise)

Preceding gene: 21226777

Following gene: 21226779

Centisome position: 19.84

GC content: 47.49

Gene sequence:

>1314_bases
GTGAAAAAAATGCCAGAATACTGGGATCCTGAAATCGAGACAATGCCTGTGGACGACTTGAGAAAGTTGCAGGAAGAAAA
ATTGAAAAAACTTGTACATTACGTGTATGAGAACTCTCCTTTTTACAGAAAAAGGTTTGACGAACACGGGGTTCGCCCGG
AAGACATCCAGACTCTCGAAGATGTCAGGAAATTACCTTTTACATATAAGCAGGATCTCAGAGATACCTACCCTACAGGG
ATGTTTTGCGTTCCCAATTCAAAGCTTGCCCGCTTCCATGCTTCTTCGGGTACCACAGGCAAACCAACTGTTGTAGGATA
CACACATAAGGATATTGACAACTGGGCAGAATCCCTTGCCCGTGCTCTCACCTCCGTAGGAGTGGGGAAAGAAGATATCC
TTCAGGTAAGCTACGGGTACGGGCTTTTTACAGGAGGACTCGGCGCCCACTATGGAAGTGAAAAAGTGGGAGCAACCGTA
CTCCCCACAAGTTCGGGAAACACAGAAAGGCAGCTTGAACTCATGAAAGACCTCGGCACGACATCCATAGCCTGCACCCC
CTCTTACTTCCTGTACATGATTGAGACCGCCAGGAAAGAAGGAATCAACATCAGGAATGATACAAAATTAAGGAAGGGAT
TCTTCGGAGCCGAACCCTGGTCCGAGGAGCTCAAGAGGAGAATAGAAGAGGAATCAGGGATTAAAGCCTATGATATTTAC
GGGACTTCGGAACTCAGCGGCCCTCTTTTTACCGAATGCGACGAACAGTGCGGCATCCATATCTGGGCAGACCTTTTCCT
TGTAGAGATTCTGGACCCTGAAACCGGTGAGCCTGTTCCTGATGGAGAGACAGGGGAACTTGTAATTACCACCCTTGCAA
AAGAAGCAAACCCCCTTATCCGCTACAGAATCAAAGACCTTACCAGAAAACTGTCTGAGCCCTGTAAATGCGGCAGGACG
CACCCGAGGATTACACGCATCAGCGGACGCTCGGATGACATGATCATCGTGCGCGGCATAAATGTATTCCCCGGCCAGGT
AGAATCGGTTTTGATGAATATCCCTGAAGTCGGAAACCATTTCATGATAATTGTGGACAGAATAGGTCCGCTCGACTCAA
TGAAGGTGCAGATAGAGATGCATGAGTCTGCCTTCAGTGATAAAATGTCGGATATGATGGCCCTTAAAGGGAAAATCGCA
AGCGCTTTAAAGAGCGTGCTTAACCTTGCAGTCGAAGTAGAGCTTGTCGAACACGGCTCTCTTCCACGTTCGGAAGGGAA
ATCAAAGAAAGTTATAGACAAGAGAAAGATCTGA

Upstream 100 bases:

>100_bases
AGCATGACCTCAAGGGGCATGAAATGAAAAATATACATAAAAAAAGGCCGGAAGAGACGCAGCCTGAAACAAAAAGGTCT
CTGAATAAAGAATAAAGAGC

Downstream 100 bases:

>100_bases
AAGCTTTACATTTGAAGATCAGAAAAGCCAGGAAATAAGAAGGCCAAGAAATTTGATTTTCCACAGAGAAAAAGGAATTG
CGGAAAAATGTAAAACATTA

Product: coenzyme F390 synthetase

Products: NA

Alternate protein names: Phenylacetyl-CoA ligase; PA-CoA ligase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKKMPEYWDPEIETMPVDDLRKLQEEKLKKLVHYVYENSPFYRKRFDEHGVRPEDIQTLEDVRKLPFTYKQDLRDTYPTG
MFCVPNSKLARFHASSGTTGKPTVVGYTHKDIDNWAESLARALTSVGVGKEDILQVSYGYGLFTGGLGAHYGSEKVGATV
LPTSSGNTERQLELMKDLGTTSIACTPSYFLYMIETARKEGINIRNDTKLRKGFFGAEPWSEELKRRIEEESGIKAYDIY
GTSELSGPLFTECDEQCGIHIWADLFLVEILDPETGEPVPDGETGELVITTLAKEANPLIRYRIKDLTRKLSEPCKCGRT
HPRITRISGRSDDMIIVRGINVFPGQVESVLMNIPEVGNHFMIIVDRIGPLDSMKVQIEMHESAFSDKMSDMMALKGKIA
SALKSVLNLAVEVELVEHGSLPRSEGKSKKVIDKRKI

Sequences:

>Translated_437_residues
MKKMPEYWDPEIETMPVDDLRKLQEEKLKKLVHYVYENSPFYRKRFDEHGVRPEDIQTLEDVRKLPFTYKQDLRDTYPTG
MFCVPNSKLARFHASSGTTGKPTVVGYTHKDIDNWAESLARALTSVGVGKEDILQVSYGYGLFTGGLGAHYGSEKVGATV
LPTSSGNTERQLELMKDLGTTSIACTPSYFLYMIETARKEGINIRNDTKLRKGFFGAEPWSEELKRRIEEESGIKAYDIY
GTSELSGPLFTECDEQCGIHIWADLFLVEILDPETGEPVPDGETGELVITTLAKEANPLIRYRIKDLTRKLSEPCKCGRT
HPRITRISGRSDDMIIVRGINVFPGQVESVLMNIPEVGNHFMIIVDRIGPLDSMKVQIEMHESAFSDKMSDMMALKGKIA
SALKSVLNLAVEVELVEHGSLPRSEGKSKKVIDKRKI
>Mature_437_residues
MKKMPEYWDPEIETMPVDDLRKLQEEKLKKLVHYVYENSPFYRKRFDEHGVRPEDIQTLEDVRKLPFTYKQDLRDTYPTG
MFCVPNSKLARFHASSGTTGKPTVVGYTHKDIDNWAESLARALTSVGVGKEDILQVSYGYGLFTGGLGAHYGSEKVGATV
LPTSSGNTERQLELMKDLGTTSIACTPSYFLYMIETARKEGINIRNDTKLRKGFFGAEPWSEELKRRIEEESGIKAYDIY
GTSELSGPLFTECDEQCGIHIWADLFLVEILDPETGEPVPDGETGELVITTLAKEANPLIRYRIKDLTRKLSEPCKCGRT
HPRITRISGRSDDMIIVRGINVFPGQVESVLMNIPEVGNHFMIIVDRIGPLDSMKVQIEMHESAFSDKMSDMMALKGKIA
SALKSVLNLAVEVELVEHGSLPRSEGKSKKVIDKRKI

Specific function: Catalyzes the activation of phenylacetic acid to phenylacetyl-CoA [H]

COG id: COG1541

COG function: function code H; Coenzyme F390 synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787664, Length=431, Percent_Identity=48.9559164733179, Blast_Score=414, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011880 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.30 [H]

Molecular weight: Translated: 49206; Mature: 49206

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMPEYWDPEIETMPVDDLRKLQEEKLKKLVHYVYENSPFYRKRFDEHGVRPEDIQTLE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
DVRKLPFTYKQDLRDTYPTGMFCVPNSKLARFHASSGTTGKPTVVGYTHKDIDNWAESLA
HHHHCCCHHHHHHHHHCCCCEEECCCCHHHEEECCCCCCCCCEEEEECHHHHHHHHHHHH
RALTSVGVGKEDILQVSYGYGLFTGGLGAHYGSEKVGATVLPTSSGNTERQLELMKDLGT
HHHHHCCCCHHHHEEEECCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCC
TSIACTPSYFLYMIETARKEGINIRNDTKLRKGFFGAEPWSEELKRRIEEESGIKAYDIY
CEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEC
GTSELSGPLFTECDEQCGIHIWADLFLVEILDPETGEPVPDGETGELVITTLAKEANPLI
CCCCCCCCCHHHHHHHCCEEHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEEHHCCCHHH
RYRIKDLTRKLSEPCKCGRTHPRITRISGRSDDMIIVRGINVFPGQVESVLMNIPEVGNH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCC
FMIIVDRIGPLDSMKVQIEMHESAFSDKMSDMMALKGKIASALKSVLNLAVEVELVEHGS
EEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCC
LPRSEGKSKKVIDKRKI
CCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKKMPEYWDPEIETMPVDDLRKLQEEKLKKLVHYVYENSPFYRKRFDEHGVRPEDIQTLE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHH
DVRKLPFTYKQDLRDTYPTGMFCVPNSKLARFHASSGTTGKPTVVGYTHKDIDNWAESLA
HHHHCCCHHHHHHHHHCCCCEEECCCCHHHEEECCCCCCCCCEEEEECHHHHHHHHHHHH
RALTSVGVGKEDILQVSYGYGLFTGGLGAHYGSEKVGATVLPTSSGNTERQLELMKDLGT
HHHHHCCCCHHHHEEEECCCCEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCC
TSIACTPSYFLYMIETARKEGINIRNDTKLRKGFFGAEPWSEELKRRIEEESGIKAYDIY
CEEEECHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEC
GTSELSGPLFTECDEQCGIHIWADLFLVEILDPETGEPVPDGETGELVITTLAKEANPLI
CCCCCCCCCHHHHHHHCCEEHHHHHHHHHEECCCCCCCCCCCCCCCEEEEEEHHCCCHHH
RYRIKDLTRKLSEPCKCGRTHPRITRISGRSDDMIIVRGINVFPGQVESVLMNIPEVGNH
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCC
FMIIVDRIGPLDSMKVQIEMHESAFSDKMSDMMALKGKIASALKSVLNLAVEVELVEHGS
EEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHCCC
LPRSEGKSKKVIDKRKI
CCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]