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The map label for this gene is gmd [H]

Identifier: 21226761

GI number: 21226761

Start: 789343

End: 790398

Strand: Reverse

Name: gmd [H]

Synonym: MM_0659

Alternate gene names: 21226761

Gene position: 790398-789343 (Counterclockwise)

Preceding gene: 21226762

Following gene: 21226760

Centisome position: 19.3

GC content: 41.67

Gene sequence:

>1056_bases
ATGACTAAAACAGCCTTAATTACCGGAATAACGGGCCAGGATGGGGCTTACTTAGCGGAATTTCTCCTTAACAAAGGATA
TGTTGTACACGGGATCAAACGTAGATCCTCTTCATTCAATACCGCAAGAGTTGACCATCTTTATAAAGACCCCCATGAGC
GAAATGTAAATTTTTTTATGCATTACGGCGATCTTACGGATTCTACTAACCTTATCAGGATAATTCAGGAAGTTCAGCCT
GATGAAATTTACAACCTTGCCGCTCAAAGCCATGTGCAGGTGTCTTTTGAGACCCCTGAATACACAGCAAATTCCGATGG
ACTTGGCACATTACGTCTTCTGGAGGCTATTCGAATCCTTGGCATGGAGAAAAAAACGAAATTATACCAGGCTTCAACCA
GTGAACTTTACGGAAAAGTCCAGGATATCCCTCAGAAAGAAACTACTCCCTTCTATCCAAGAAGCCCTTATGCAGCGGCT
AAACTATACGCTTACTGGATTACGGTTAACTATCGGGAAGCCTACGGCATTTTTGCATGTAATGGAATTTTGTTCAATCA
CGAATCTCCTATTCGGGGAGAAACATTCGTTACCAGAAAGATCACTATGGCAGCCACAAAAATAAAGCATGGACTTCAGG
AGAAGCTTTACCTTGGTAATCTTGATGCCAAAAGGGATTGGGGATTTGCAAAGGATTATGTGGAAGCAATGTGGCTGATC
CTTCAGCAAGAATATCCAGAAGACTATGTGATTGCTACTGGAGAGACTCACTCGGTAAGGGAATTTACGGAATTAGCTTT
TAAGGAAGTAGGGATCGAGGTTTTGTGGAAAGGCAAAGGTAGCGATGAAGTCGGAATTGATTCCAGTACAGGTAAAGTTC
TGGTAGAAGTAGATCCCAGATATTATAGACCTACGGAAGTAGATTTACTAATTGGAGATCCCTCAAAAGCAAAGGAAAAA
CTTGGCTGGAAACCAAAAGTAAAACTGGAAGAGCTGGTAAAAATCATGATAACGGCCGACGAGAAAGCTGTACAGGAAAA
TCACACTTTTGAGTAA

Upstream 100 bases:

>100_bases
GAGAAGATGAGCCTATTAGATTCATGCTAAGATTAATTAAACAGTTGATTGTTCTTAAGTAAACATTAAATATTTTAATA
CATAGTTATCAGGGTATAAA

Downstream 100 bases:

>100_bases
AGTTCAATGGTGATCACATGGATAAAAGGTCAAAAATTTATGTGGCTGGCCACCGAGGTCTTGTAGGTTCAGCTCTGAAA
AGAAAACTTGAGTCAAAAGA

Product: GDP-mannose 4,6 dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTKTALITGITGQDGAYLAEFLLNKGYVVHGIKRRSSSFNTARVDHLYKDPHERNVNFFMHYGDLTDSTNLIRIIQEVQP
DEIYNLAAQSHVQVSFETPEYTANSDGLGTLRLLEAIRILGMEKKTKLYQASTSELYGKVQDIPQKETTPFYPRSPYAAA
KLYAYWITVNYREAYGIFACNGILFNHESPIRGETFVTRKITMAATKIKHGLQEKLYLGNLDAKRDWGFAKDYVEAMWLI
LQQEYPEDYVIATGETHSVREFTELAFKEVGIEVLWKGKGSDEVGIDSSTGKVLVEVDPRYYRPTEVDLLIGDPSKAKEK
LGWKPKVKLEELVKIMITADEKAVQENHTFE

Sequences:

>Translated_351_residues
MTKTALITGITGQDGAYLAEFLLNKGYVVHGIKRRSSSFNTARVDHLYKDPHERNVNFFMHYGDLTDSTNLIRIIQEVQP
DEIYNLAAQSHVQVSFETPEYTANSDGLGTLRLLEAIRILGMEKKTKLYQASTSELYGKVQDIPQKETTPFYPRSPYAAA
KLYAYWITVNYREAYGIFACNGILFNHESPIRGETFVTRKITMAATKIKHGLQEKLYLGNLDAKRDWGFAKDYVEAMWLI
LQQEYPEDYVIATGETHSVREFTELAFKEVGIEVLWKGKGSDEVGIDSSTGKVLVEVDPRYYRPTEVDLLIGDPSKAKEK
LGWKPKVKLEELVKIMITADEKAVQENHTFE
>Mature_350_residues
TKTALITGITGQDGAYLAEFLLNKGYVVHGIKRRSSSFNTARVDHLYKDPHERNVNFFMHYGDLTDSTNLIRIIQEVQPD
EIYNLAAQSHVQVSFETPEYTANSDGLGTLRLLEAIRILGMEKKTKLYQASTSELYGKVQDIPQKETTPFYPRSPYAAAK
LYAYWITVNYREAYGIFACNGILFNHESPIRGETFVTRKITMAATKIKHGLQEKLYLGNLDAKRDWGFAKDYVEAMWLIL
QQEYPEDYVIATGETHSVREFTELAFKEVGIEVLWKGKGSDEVGIDSSTGKVLVEVDPRYYRPTEVDLLIGDPSKAKEKL
GWKPKVKLEELVKIMITADEKAVQENHTFE

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=66.8604651162791, Blast_Score=479, Evalue=1e-135,
Organism=Escherichia coli, GI1788366, Length=357, Percent_Identity=66.1064425770308, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI48994969, Length=341, Percent_Identity=26.6862170087977, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788353, Length=300, Percent_Identity=25, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=340, Percent_Identity=65, Blast_Score=470, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=63.5294117647059, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=63.5294117647059, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17539422, Length=347, Percent_Identity=62.536023054755, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI133901788, Length=347, Percent_Identity=62.536023054755, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI133901786, Length=347, Percent_Identity=62.536023054755, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17539532, Length=341, Percent_Identity=26.3929618768328, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24158427, Length=346, Percent_Identity=64.7398843930636, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21356223, Length=338, Percent_Identity=26.0355029585799, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 39985; Mature: 39854

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTALITGITGQDGAYLAEFLLNKGYVVHGIKRRSSSFNTARVDHLYKDPHERNVNFFM
CCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHHHCCCCCCCCEEEE
HYGDLTDSTNLIRIIQEVQPDEIYNLAAQSHVQVSFETPEYTANSDGLGTLRLLEAIRIL
EECCCCCCHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
GMEKKTKLYQASTSELYGKVQDIPQKETTPFYPRSPYAAAKLYAYWITVNYREAYGIFAC
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEEEEEEEHHHCEEEEE
NGILFNHESPIRGETFVTRKITMAATKIKHGLQEKLYLGNLDAKRDWGFAKDYVEAMWLI
CEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHH
LQQEYPEDYVIATGETHSVREFTELAFKEVGIEVLWKGKGSDEVGIDSSTGKVLVEVDPR
HHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEECCC
YYRPTEVDLLIGDPSKAKEKLGWKPKVKLEELVKIMITADEKAVQENHTFE
EECCCEEEEEECCCHHHHHHCCCCCCCCHHHHHEEEEECCHHHHHCCCCCC
>Mature Secondary Structure 
TKTALITGITGQDGAYLAEFLLNKGYVVHGIKRRSSSFNTARVDHLYKDPHERNVNFFM
CCCEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHHHCCCCCCCCEEEE
HYGDLTDSTNLIRIIQEVQPDEIYNLAAQSHVQVSFETPEYTANSDGLGTLRLLEAIRIL
EECCCCCCHHHHHHHHHCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
GMEKKTKLYQASTSELYGKVQDIPQKETTPFYPRSPYAAAKLYAYWITVNYREAYGIFAC
CCCHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCHHEEEEEEEEEEEEHHHCEEEEE
NGILFNHESPIRGETFVTRKITMAATKIKHGLQEKLYLGNLDAKRDWGFAKDYVEAMWLI
CEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHH
LQQEYPEDYVIATGETHSVREFTELAFKEVGIEVLWKGKGSDEVGIDSSTGKVLVEVDPR
HHHCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEECCC
YYRPTEVDLLIGDPSKAKEKLGWKPKVKLEELVKIMITADEKAVQENHTFE
EECCCEEEEEECCCHHHHHHCCCCCCCCHHHHHEEEEECCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]