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The map label for this gene is 21226573

Identifier: 21226573

GI number: 21226573

Start: 594780

End: 595637

Strand: Reverse

Name: 21226573

Synonym: MM_0471

Alternate gene names: NA

Gene position: 595637-594780 (Counterclockwise)

Preceding gene: 21226574

Following gene: 21226572

Centisome position: 14.54

GC content: 48.72

Gene sequence:

>858_bases
TTGAGCTGGATGTACAGACTTGATCCCGATTTTTTCAACCTTGATTATACCCTCGACTGCGGCCAGGTCTTCCGCTGGGA
AAAGAATGGAGACTGGTGGACAGGGGTTGTAGGAAACAATGTTATCCGTCTTTCCCAGGAGGAAGACAGCCGGGAACTGC
TAATTGACTCCAAACTCCCTCCCGAATTTTTCTCCCGTTATTTTCGCCTTGACGACGACCTCCCTTTAATTTACGAGAGC
ATCAACAGGGACCTTCTGATAGACAGGGCAATAAAAAGATATAAGGGCCTGCGCCTGATCCGTCAGGATCCCTGGGAATG
CCTGATTTCTTACATGCTTGCCACGGCTTCGAGCATTCCGACAATTCAAAAAAGGATCTGTCTTCTGAGCCGGATCTTCG
GACAGGAGCTCGAAGACGGATATTTCAGTTTTCCGGACCCTGAAACTCTTGCAAACGCTGATATGTCCATGCTTGACCTC
TGTAAGCTGGGCTTCAGGGCAGACCGCATAAAAATGGCAGCAGAGGAAGTCTGCTCAGGGGAACTGGACTTTAACACCCT
TTTCCGCCTTGAATACAAATACGCCAGAGAACGCCTTATGAGGCTCCGCGGCATAGGGGAAAAAGTTGCTGACTGCGTCC
TCCTTTTCGCTTTTGAGAAAATGGAGTCTTTCCCTGTAGATACCCACATCAGGCAGATCATCCAGCATTACCATATCGAT
GACAGCTACTTCGAAACCTGCACAAACCTGAGCTGTATGGGAGACTGGGGACGGGAATATTTCGGACGCTACTGCGGGTA
TGCCCAGGAGTATCTTTATTATCAGAAAAGGGTTGAGGGGTTTGTGAGTCTTTATTGA

Upstream 100 bases:

>100_bases
GGCTGTATGCTCTGTATTCTCCCCACTCTTCTCTGCAAATCCCCGATAACTACGGTTGGGCTCGGGGACACGCTGACTGC
GGGAACTTTTTTGAGGGGGC

Downstream 100 bases:

>100_bases
ATTCTCTTCACTAATTCCTTTTTAATGATTTTTGACTTTTAGATCCAAATAATTCAATTTGATTATAAATTGATACAGGA
ACTCAAGCCTGTATTTTCTT

Product: 8-oxoguanine DNA glycosylase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSWMYRLDPDFFNLDYTLDCGQVFRWEKNGDWWTGVVGNNVIRLSQEEDSRELLIDSKLPPEFFSRYFRLDDDLPLIYES
INRDLLIDRAIKRYKGLRLIRQDPWECLISYMLATASSIPTIQKRICLLSRIFGQELEDGYFSFPDPETLANADMSMLDL
CKLGFRADRIKMAAEEVCSGELDFNTLFRLEYKYARERLMRLRGIGEKVADCVLLFAFEKMESFPVDTHIRQIIQHYHID
DSYFETCTNLSCMGDWGREYFGRYCGYAQEYLYYQKRVEGFVSLY

Sequences:

>Translated_285_residues
MSWMYRLDPDFFNLDYTLDCGQVFRWEKNGDWWTGVVGNNVIRLSQEEDSRELLIDSKLPPEFFSRYFRLDDDLPLIYES
INRDLLIDRAIKRYKGLRLIRQDPWECLISYMLATASSIPTIQKRICLLSRIFGQELEDGYFSFPDPETLANADMSMLDL
CKLGFRADRIKMAAEEVCSGELDFNTLFRLEYKYARERLMRLRGIGEKVADCVLLFAFEKMESFPVDTHIRQIIQHYHID
DSYFETCTNLSCMGDWGREYFGRYCGYAQEYLYYQKRVEGFVSLY
>Mature_284_residues
SWMYRLDPDFFNLDYTLDCGQVFRWEKNGDWWTGVVGNNVIRLSQEEDSRELLIDSKLPPEFFSRYFRLDDDLPLIYESI
NRDLLIDRAIKRYKGLRLIRQDPWECLISYMLATASSIPTIQKRICLLSRIFGQELEDGYFSFPDPETLANADMSMLDLC
KLGFRADRIKMAAEEVCSGELDFNTLFRLEYKYARERLMRLRGIGEKVADCVLLFAFEKMESFPVDTHIRQIIQHYHIDD
SYFETCTNLSCMGDWGREYFGRYCGYAQEYLYYQKRVEGFVSLY

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=287, Percent_Identity=29.9651567944251, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI8670534, Length=286, Percent_Identity=30.0699300699301, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI8670530, Length=283, Percent_Identity=29.6819787985866, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI8670542, Length=283, Percent_Identity=30.0353356890459, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI8670540, Length=283, Percent_Identity=29.6819787985866, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI8670532, Length=283, Percent_Identity=29.6819787985866, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI8670536, Length=217, Percent_Identity=29.4930875576037, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI8670538, Length=157, Percent_Identity=30.5732484076433, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323580, Length=254, Percent_Identity=28.740157480315, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640654, Length=289, Percent_Identity=28.719723183391, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 33862; Mature: 33731

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWMYRLDPDFFNLDYTLDCGQVFRWEKNGDWWTGVVGNNVIRLSQEEDSRELLIDSKLP
CCCCEECCCCEECCEEEECCCHHEEECCCCCEEEEECCCCEEEECCCCCCCCEEECCCCC
PEFFSRYFRLDDDLPLIYESINRDLLIDRAIKRYKGLRLIRQDPWECLISYMLATASSIP
HHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCH
TIQKRICLLSRIFGQELEDGYFSFPDPETLANADMSMLDLCKLGFRADRIKMAAEEVCSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCC
ELDFNTLFRLEYKYARERLMRLRGIGEKVADCVLLFAFEKMESFPVDTHIRQIIQHYHID
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
DSYFETCTNLSCMGDWGREYFGRYCGYAQEYLYYQKRVEGFVSLY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWMYRLDPDFFNLDYTLDCGQVFRWEKNGDWWTGVVGNNVIRLSQEEDSRELLIDSKLP
CCCEECCCCEECCEEEECCCHHEEECCCCCEEEEECCCCEEEECCCCCCCCEEECCCCC
PEFFSRYFRLDDDLPLIYESINRDLLIDRAIKRYKGLRLIRQDPWECLISYMLATASSIP
HHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCCH
TIQKRICLLSRIFGQELEDGYFSFPDPETLANADMSMLDLCKLGFRADRIKMAAEEVCSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCC
ELDFNTLFRLEYKYARERLMRLRGIGEKVADCVLLFAFEKMESFPVDTHIRQIIQHYHID
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
DSYFETCTNLSCMGDWGREYFGRYCGYAQEYLYYQKRVEGFVSLY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]