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The map label for this gene is fkpB [C]

Identifier: 21226484

GI number: 21226484

Start: 488339

End: 488830

Strand: Reverse

Name: fkpB [C]

Synonym: MM_0382

Alternate gene names: 21226484

Gene position: 488830-488339 (Counterclockwise)

Preceding gene: 21226485

Following gene: 21226483

Centisome position: 11.93

GC content: 44.72

Gene sequence:

>492_bases
TTGATTGTTATGACTGAGGATATAATTGAAAATTCGAATAAAGTAGTCGAAAAAGGAGATGCTGTATCCGTCCATTATGT
AGGTAAACTTGATGACGGAACGGTATTCGACACATCGGAAAAAGAAGAAGCCATGGAGGCAGGCATATACAACGAAATGA
GGGACTATGAACCTCTGAAATTCACCGTCGGAGCCGGACAGATGATCAAAGGCTTTGACGAAGGTGTGGTCGGAATGAAA
GCGGGGGAAGAAAAAATCCTTAAAATCCCTCCAGAGGAAGCATATGGGGAATACGTGGAAGAATATGCAAGGGAACTTCC
GCGTGATGCTGTGGATTTCGTTCCGGAAGTAGGGATGCAGCTGGCTACGGAAACCGGGCTCAGAGGCACTGTGACAGAAG
TAGGCGAGGAAAATTTTGTTATTGATTTCAACCATGCACTTGCAGGCAAGACCCTTACATTCAAAGTAAAGGTCATTTCA
GTGGAGGAATGA

Upstream 100 bases:

>100_bases
AAAGATTTCCGTAATTTTTATTTACTGAAGTCCTATTTTAACCGTTTTCCAGCGCCTTTTTTATCAGTACGTTTATGTAA
CATGCTTTCGTTTTGTCCTA

Downstream 100 bases:

>100_bases
AAAAAATGAGGGTCGGGAAGAGTACAATATATTTCCTGACAATGCTGCTTCTGGCAAGTATGGTTTTAGGAAGCGGATGC
ACGGATAACGGCAGCGGAGA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; MtFK; Rotamase [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MIVMTEDIIENSNKVVEKGDAVSVHYVGKLDDGTVFDTSEKEEAMEAGIYNEMRDYEPLKFTVGAGQMIKGFDEGVVGMK
AGEEKILKIPPEEAYGEYVEEYARELPRDAVDFVPEVGMQLATETGLRGTVTEVGEENFVIDFNHALAGKTLTFKVKVIS
VEE

Sequences:

>Translated_163_residues
MIVMTEDIIENSNKVVEKGDAVSVHYVGKLDDGTVFDTSEKEEAMEAGIYNEMRDYEPLKFTVGAGQMIKGFDEGVVGMK
AGEEKILKIPPEEAYGEYVEEYARELPRDAVDFVPEVGMQLATETGLRGTVTEVGEENFVIDFNHALAGKTLTFKVKVIS
VEE
>Mature_163_residues
MIVMTEDIIENSNKVVEKGDAVSVHYVGKLDDGTVFDTSEKEEAMEAGIYNEMRDYEPLKFTVGAGQMIKGFDEGVVGMK
AGEEKILKIPPEEAYGEYVEEYARELPRDAVDFVPEVGMQLATETGLRGTVTEVGEENFVIDFNHALAGKTLTFKVKVIS
VEE

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=81, Percent_Identity=43.2098765432099, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI17149844, Length=81, Percent_Identity=43.2098765432099, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI17149842, Length=81, Percent_Identity=43.2098765432099, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4503727, Length=111, Percent_Identity=36.036036036036, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1786211, Length=155, Percent_Identity=26.4516129032258, Blast_Score=67, Evalue=5e-13,
Organism=Escherichia coli, GI1789748, Length=154, Percent_Identity=30.5194805194805, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540882, Length=88, Percent_Identity=40.9090909090909, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=80, Percent_Identity=43.75, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356629, Length=84, Percent_Identity=42.8571428571429, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363946, Length=97, Percent_Identity=37.1134020618557, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17352457, Length=97, Percent_Identity=37.1134020618557, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24655568, Length=81, Percent_Identity=39.5061728395062, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18035; Mature: 18035

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVMTEDIIENSNKVVEKGDAVSVHYVGKLDDGTVFDTSEKEEAMEAGIYNEMRDYEPLK
CEEECHHHHCCCCCEEECCCEEEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHCCCCEE
FTVGAGQMIKGFDEGVVGMKAGEEKILKIPPEEAYGEYVEEYARELPRDAVDFVPEVGMQ
EEECCCHHHHCCCCCEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LATETGLRGTVTEVGEENFVIDFNHALAGKTLTFKVKVISVEE
HHHHCCCCCCHHHCCCCCEEEEECCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MIVMTEDIIENSNKVVEKGDAVSVHYVGKLDDGTVFDTSEKEEAMEAGIYNEMRDYEPLK
CEEECHHHHCCCCCEEECCCEEEEEEEEECCCCCEECCCCHHHHHHHHHHHHHHCCCCEE
FTVGAGQMIKGFDEGVVGMKAGEEKILKIPPEEAYGEYVEEYARELPRDAVDFVPEVGMQ
EEECCCHHHHCCCCCEECCCCCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LATETGLRGTVTEVGEENFVIDFNHALAGKTLTFKVKVISVEE
HHHHCCCCCCHHHCCCCCEEEEECCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9440528 [H]