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The map label for this gene is glmU [H]

Identifier: 21226480

GI number: 21226480

Start: 485270

End: 486448

Strand: Reverse

Name: glmU [H]

Synonym: MM_0378

Alternate gene names: 21226480

Gene position: 486448-485270 (Counterclockwise)

Preceding gene: 21226481

Following gene: 21226479

Centisome position: 11.88

GC content: 45.89

Gene sequence:

>1179_bases
ATGAAAGCATGTATCATGTGCGGAGGTGCAGGGACAAGGCTCAGACCGCTGACCTTCAAACACCCTAAACCCAGCATACC
GATTCTCAATAAACCGTCAGTAAGGCACCTGATAGAGCACCTTTCAAGAGAAGGGTTCAATGAAATAGTTATGACCCTGG
GATATATGGGGGAGCGCATAGAAGAACAGCTCGGGGACGGGCACATATTCGGGGTACATATTGAGTATGTGTATGAAAAG
GAGAAGATGGGCACTGCAGGCGGGGTTAAAAACGCAGAGGAGTATCTGAAAAATGAGCCTTTTATCGTGCTTGGGGGAGA
CCACGTACTTAACCTTGACCTGAGGGAGATGTACCGTTTTCACGAGACCAATGACGCAATAGTGACCATAGGGCTACTTT
CAATTGATGACCCGAGAGAATTCGGGATTGCGGATATGGATATAAATAACAGGATCCACCGCTTCCTCGAAAAACCCAAG
TCCGGGCAAATTTTTAGCAACCTTGCAAGTACAGGCATTTACATCTGTGACCCCGAAATCTTCGACTGGATACCCGAGAA
TAAAAAGTATGATTTTGCAAAAGACCTTTTCCCTTCCCTGCTTGCAGCAGATGAAAAAATTAACGGCATGCTTGTCCGGG
GGAAATGGACTGATGTAGGGAGTTCGGCAGCTTACAGGCAGGCCCAGCGCTGGATGCTTGACGCTCTTCCCGGGACCACT
ATAGAAGGAAACTTTACGACAAGAAACGCAAGAATACGCGGGCCTTTATCCATAGGAAACAACGTTTGCATAGGTTCGAA
TTCTTCCCTTGTAGGACCGATTGTTATAGGGGAAAACACTGTAATAGGTGACAACGTCCTTGTGGGGCCTTACAGCGTAA
TAGGCGCGAACTGCACTATTGACGACAATGCAAAAATTCTTTCATCCTATCTTTTTGATTATGTCTCTATAGGAAAAGGC
TCCAATATCTCAGGGTCAGTGGTTGCCGATGAAACAGCTGTAGGGGAAAAATGCAGCCTTGAAAACGGGACAGTGATCGG
GCACAGAGTGACCATAGGAGATAACTCCACCATACATTCGGGAGTTAAAATATGGCCTGAAGTGATAATTGATAATGATT
CCAGTATAGAGGAAACAATTGTTAACCTCAATTATGATACCTCACAGGAAGGGTCGTGA

Upstream 100 bases:

>100_bases
TACGGTATCACCCTCTCTCTGGAATAACCGTTATCAATAAACTTCAAAATGGAACAATATATCGTTAACAATATATCCAT
AGAACAACATTGGGAAAAAT

Downstream 100 bases:

>100_bases
ACAGGGCTTAAAAGTCGGGTTTCCAGGATCAGGTACATATTTCCGGTAAAATGTGTTTTCATAGTTGTTTCGGGTTTAAA
AAGGAGAACTTTTAATAAAT

Product: sugar-phosphate nucleotydyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKACIMCGGAGTRLRPLTFKHPKPSIPILNKPSVRHLIEHLSREGFNEIVMTLGYMGERIEEQLGDGHIFGVHIEYVYEK
EKMGTAGGVKNAEEYLKNEPFIVLGGDHVLNLDLREMYRFHETNDAIVTIGLLSIDDPREFGIADMDINNRIHRFLEKPK
SGQIFSNLASTGIYICDPEIFDWIPENKKYDFAKDLFPSLLAADEKINGMLVRGKWTDVGSSAAYRQAQRWMLDALPGTT
IEGNFTTRNARIRGPLSIGNNVCIGSNSSLVGPIVIGENTVIGDNVLVGPYSVIGANCTIDDNAKILSSYLFDYVSIGKG
SNISGSVVADETAVGEKCSLENGTVIGHRVTIGDNSTIHSGVKIWPEVIIDNDSSIEETIVNLNYDTSQEGS

Sequences:

>Translated_392_residues
MKACIMCGGAGTRLRPLTFKHPKPSIPILNKPSVRHLIEHLSREGFNEIVMTLGYMGERIEEQLGDGHIFGVHIEYVYEK
EKMGTAGGVKNAEEYLKNEPFIVLGGDHVLNLDLREMYRFHETNDAIVTIGLLSIDDPREFGIADMDINNRIHRFLEKPK
SGQIFSNLASTGIYICDPEIFDWIPENKKYDFAKDLFPSLLAADEKINGMLVRGKWTDVGSSAAYRQAQRWMLDALPGTT
IEGNFTTRNARIRGPLSIGNNVCIGSNSSLVGPIVIGENTVIGDNVLVGPYSVIGANCTIDDNAKILSSYLFDYVSIGKG
SNISGSVVADETAVGEKCSLENGTVIGHRVTIGDNSTIHSGVKIWPEVIIDNDSSIEETIVNLNYDTSQEGS
>Mature_392_residues
MKACIMCGGAGTRLRPLTFKHPKPSIPILNKPSVRHLIEHLSREGFNEIVMTLGYMGERIEEQLGDGHIFGVHIEYVYEK
EKMGTAGGVKNAEEYLKNEPFIVLGGDHVLNLDLREMYRFHETNDAIVTIGLLSIDDPREFGIADMDINNRIHRFLEKPK
SGQIFSNLASTGIYICDPEIFDWIPENKKYDFAKDLFPSLLAADEKINGMLVRGKWTDVGSSAAYRQAQRWMLDALPGTT
IEGNFTTRNARIRGPLSIGNNVCIGSNSSLVGPIVIGENTVIGDNVLVGPYSVIGANCTIDDNAKILSSYLFDYVSIGKG
SNISGSVVADETAVGEKCSLENGTVIGHRVTIGDNSTIHSGVKIWPEVIIDNDSSIEETIVNLNYDTSQEGS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=360, Percent_Identity=28.3333333333333, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI11761619, Length=380, Percent_Identity=28.4210526315789, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI31881779, Length=363, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI45447090, Length=363, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI83267879, Length=408, Percent_Identity=20.8333333333333, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789837, Length=398, Percent_Identity=25.3768844221106, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790224, Length=194, Percent_Identity=31.4432989690722, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788351, Length=247, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=357, Percent_Identity=30.5322128851541, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17509979, Length=351, Percent_Identity=25.6410256410256, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=338, Percent_Identity=25.1479289940828, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=386, Percent_Identity=33.6787564766839, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355443, Length=364, Percent_Identity=30.2197802197802, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24644084, Length=364, Percent_Identity=30.2197802197802, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24653912, Length=368, Percent_Identity=25.2717391304348, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 43026; Mature: 43026

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACIMCGGAGTRLRPLTFKHPKPSIPILNKPSVRHLIEHLSREGFNEIVMTLGYMGERI
CCEEEEECCCCCEECCEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EEQLGDGHIFGVHIEYVYEKEKMGTAGGVKNAEEYLKNEPFIVLGGDHVLNLDLREMYRF
HHHHCCCCEEEEEEEEEEEHHHCCCCCCCCCHHHHHCCCCEEEECCCEEEECCHHHHHHH
HETNDAIVTIGLLSIDDPREFGIADMDINNRIHRFLEKPKSGQIFSNLASTGIYICDPEI
HCCCCEEEEEEEEECCCCHHCCEEECCHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCHH
FDWIPENKKYDFAKDLFPSLLAADEKINGMLVRGKWTDVGSSAAYRQAQRWMLDALPGTT
HHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
IEGNFTTRNARIRGPLSIGNNVCIGSNSSLVGPIVIGENTVIGDNVLVGPYSVIGANCTI
EECCEEECCCEEEECCCCCCEEEECCCCCEEEEEEECCCEEECCCEEECCHHHEECCEEE
DDNAKILSSYLFDYVSIGKGSNISGSVVADETAVGEKCSLENGTVIGHRVTIGDNSTIHS
CCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
GVKIWPEVIIDNDSSIEETIVNLNYDTSQEGS
CCEECEEEEECCCCCHHHHEEECCCCCCCCCC
>Mature Secondary Structure
MKACIMCGGAGTRLRPLTFKHPKPSIPILNKPSVRHLIEHLSREGFNEIVMTLGYMGERI
CCEEEEECCCCCEECCEEECCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EEQLGDGHIFGVHIEYVYEKEKMGTAGGVKNAEEYLKNEPFIVLGGDHVLNLDLREMYRF
HHHHCCCCEEEEEEEEEEEHHHCCCCCCCCCHHHHHCCCCEEEECCCEEEECCHHHHHHH
HETNDAIVTIGLLSIDDPREFGIADMDINNRIHRFLEKPKSGQIFSNLASTGIYICDPEI
HCCCCEEEEEEEEECCCCHHCCEEECCHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCHH
FDWIPENKKYDFAKDLFPSLLAADEKINGMLVRGKWTDVGSSAAYRQAQRWMLDALPGTT
HHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
IEGNFTTRNARIRGPLSIGNNVCIGSNSSLVGPIVIGENTVIGDNVLVGPYSVIGANCTI
EECCEEECCCEEEECCCCCCEEEECCCCCEEEEEEECCCEEECCCEEECCHHHEECCEEE
DDNAKILSSYLFDYVSIGKGSNISGSVVADETAVGEKCSLENGTVIGHRVTIGDNSTIHS
CCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
GVKIWPEVIIDNDSSIEETIVNLNYDTSQEGS
CCEECEEEEECCCCCHHHHEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]