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The map label for this gene is glmS

Identifier: 21226402

GI number: 21226402

Start: 400931

End: 402787

Strand: Direct

Name: glmS

Synonym: MM_0300

Alternate gene names: 21226402

Gene position: 400931-402787 (Clockwise)

Preceding gene: 21226401

Following gene: 21226403

Centisome position: 9.79

GC content: 46.85

Gene sequence:

>1857_bases
ATGTGTGGAATTGTAGGGTATGCAGGGCGAAATGCTGCTGCGCCGGTTATAATAGAATCTCTTAAAAAACTCGAATACAG
GGGATATGACTCCGCAGGGGTTACTGTCCTTGGAAGCGGGGTTGAGACATACAAAGCAGTGGGAAAAATCATAAATCTTG
AATCAGAAATTCCGAAAAACCTGAAAGGAGCTATCGGGATAGGACATACTCGCTGGGCAACTCACGGCCGCCCAAGTACG
GAAAATGCCCATCCCCATAATTCGGGAGGAAACCCTGTAAAAATCTCACTTGTACATAACGGGATTATTGAGAATTACAT
GGCGCTAAAAGAGCGGCTTATCGGAGAAGGTTATGAATTCAAATCCGAAACCGATACCGAAGTTATCGCACATCTTCTGC
ACAAACACATATATGGAAGCCCGGATGGAAAAGAAGCCCGGAATAATCTTCTTGCAGGGCTCAGGGAAGCTTTAAAAGAG
ATTGAAGGGTCATATGCACTTGCAGTAATCTCTGCGGACGAGCAGGGAAAACTTGTTCTTGCCCGCAAGGACAGCCCTCT
GGTTATAGGGCTCGGGAAAGGGGAAAATTTTGCTGCATCTGATGTGACTGCTTTTCTGATTCATACCAGAGACGTAATCT
TTGTCGATGACTTTGAGACCGCAGTCCTGACACCTGACAGCGTGGAGATATTTGACAGGGAAGGAAAACTCAAAGAAAAG
AAGATAGAAAAAATAGAGTGGGACTTTGAAGCTGCGGAAAAAGCAGGTTATGAACATTTCATGCTTAAAGAAATCCATGA
GCAGGTCAGCGCAATCCACAATACCCTGGCAGGAAAGGTCTCGGAGCTTGAAGGAGCCATATACTTAAAGGAGCTGAACC
TCAATGATGACGAAATAAAGAAACTGTCAAGGGTTCAGATTCTCGCCTGCGGGACTTCCTGGCACGCAGGCTTGCTGGGG
AAATACCTTTTTGAACAGCTGGCAGGAATTCACTGCGATATTGACATCTGCTCCGAATACAGGTATAGAAACCCTGTTAT
GCATGAAGGGACCCTCGCAATTGCTATTACCCAGTCAGGAGAGACTGCAGACACACTTGCAGCTGTTCGGGAAATCATGT
CTTACAACTGCCCCACCCTTGCAATCACGAATGTTGTGGGAAGCACAATAACAAGAGAAGCAAACAGTGTTCTCTATACC
CGGGCAGGCCCGGAGATAGGGGTTGCTGCCACGAAGACTTTCAGTACCCAGCTTATCCTCCTTTATCTCCTCGCTGTAAA
ATTCGCTCTCGTGAGGGGCAAACTCAGTCCTGACTACGTGAAAAGTTTTATTACGGAAATCAGAAAGGTCCCGGGTGAGA
TCCAGCAGATCCTCAACCAGAAAGAAGTGATAAGGGAATGTGCTGAGAACTTTGCCTGTTCAAAGAGCTATTTCTTCCTT
GGAAGGCACCTGAGCTACCCCATAGCACTCGAAGGAGCCCTGAAGCTCAAAGAGATCTCATATGTACATGCCGAAGGCTT
TGCTGCAGGGGAACTGAAACACGGCCCTATTGCCCTGCTTGACGAAGGGGCTCCTGTGGTTGCGATTGCCACGAAAGGGC
AGACTTATGAGAAGATGCTCAGCAACATAAAAGAAGTGAAAGCCAGGGACGCGTATGTAATAGCAGTTGCCAATATCAAT
GATACTGAAATAGGAAAATATGCTGACGTTGTCCTGAGAGTTCCCTCGTGTGACGAACTTCTGGCTCCCCTTTTGAGTGT
TGTCGTACTTCAGTTGCTTGCTTATTACACTGCTCTTGCCAGGGACTGCGCTATTGACAAGCCCCGTAACCTTGCAAAGA
GTGTAACTGTAGAATAA

Upstream 100 bases:

>100_bases
ATGATAGCGGTAAACTGTCAGGTAGAGTCCGGAAATACAATTTACAGAGACCTGTCCCGTGATTCGGTGGTCCTCTAAGC
TCGTAAGAAGGAGATAAAAA

Downstream 100 bases:

>100_bases
ATACACCACTATTAAATGATCGGTTAATTAAACCATAAACAAGCTTTCAGAAAAATTGAACTTCAGGAAATATGGAGTGG
GATTTATGAAACTTTTCGGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MCGIVGYAGRNAAAPVIIESLKKLEYRGYDSAGVTVLGSGVETYKAVGKIINLESEIPKNLKGAIGIGHTRWATHGRPST
ENAHPHNSGGNPVKISLVHNGIIENYMALKERLIGEGYEFKSETDTEVIAHLLHKHIYGSPDGKEARNNLLAGLREALKE
IEGSYALAVISADEQGKLVLARKDSPLVIGLGKGENFAASDVTAFLIHTRDVIFVDDFETAVLTPDSVEIFDREGKLKEK
KIEKIEWDFEAAEKAGYEHFMLKEIHEQVSAIHNTLAGKVSELEGAIYLKELNLNDDEIKKLSRVQILACGTSWHAGLLG
KYLFEQLAGIHCDIDICSEYRYRNPVMHEGTLAIAITQSGETADTLAAVREIMSYNCPTLAITNVVGSTITREANSVLYT
RAGPEIGVAATKTFSTQLILLYLLAVKFALVRGKLSPDYVKSFITEIRKVPGEIQQILNQKEVIRECAENFACSKSYFFL
GRHLSYPIALEGALKLKEISYVHAEGFAAGELKHGPIALLDEGAPVVAIATKGQTYEKMLSNIKEVKARDAYVIAVANIN
DTEIGKYADVVLRVPSCDELLAPLLSVVVLQLLAYYTALARDCAIDKPRNLAKSVTVE

Sequences:

>Translated_618_residues
MCGIVGYAGRNAAAPVIIESLKKLEYRGYDSAGVTVLGSGVETYKAVGKIINLESEIPKNLKGAIGIGHTRWATHGRPST
ENAHPHNSGGNPVKISLVHNGIIENYMALKERLIGEGYEFKSETDTEVIAHLLHKHIYGSPDGKEARNNLLAGLREALKE
IEGSYALAVISADEQGKLVLARKDSPLVIGLGKGENFAASDVTAFLIHTRDVIFVDDFETAVLTPDSVEIFDREGKLKEK
KIEKIEWDFEAAEKAGYEHFMLKEIHEQVSAIHNTLAGKVSELEGAIYLKELNLNDDEIKKLSRVQILACGTSWHAGLLG
KYLFEQLAGIHCDIDICSEYRYRNPVMHEGTLAIAITQSGETADTLAAVREIMSYNCPTLAITNVVGSTITREANSVLYT
RAGPEIGVAATKTFSTQLILLYLLAVKFALVRGKLSPDYVKSFITEIRKVPGEIQQILNQKEVIRECAENFACSKSYFFL
GRHLSYPIALEGALKLKEISYVHAEGFAAGELKHGPIALLDEGAPVVAIATKGQTYEKMLSNIKEVKARDAYVIAVANIN
DTEIGKYADVVLRVPSCDELLAPLLSVVVLQLLAYYTALARDCAIDKPRNLAKSVTVE
>Mature_618_residues
MCGIVGYAGRNAAAPVIIESLKKLEYRGYDSAGVTVLGSGVETYKAVGKIINLESEIPKNLKGAIGIGHTRWATHGRPST
ENAHPHNSGGNPVKISLVHNGIIENYMALKERLIGEGYEFKSETDTEVIAHLLHKHIYGSPDGKEARNNLLAGLREALKE
IEGSYALAVISADEQGKLVLARKDSPLVIGLGKGENFAASDVTAFLIHTRDVIFVDDFETAVLTPDSVEIFDREGKLKEK
KIEKIEWDFEAAEKAGYEHFMLKEIHEQVSAIHNTLAGKVSELEGAIYLKELNLNDDEIKKLSRVQILACGTSWHAGLLG
KYLFEQLAGIHCDIDICSEYRYRNPVMHEGTLAIAITQSGETADTLAAVREIMSYNCPTLAITNVVGSTITREANSVLYT
RAGPEIGVAATKTFSTQLILLYLLAVKFALVRGKLSPDYVKSFITEIRKVPGEIQQILNQKEVIRECAENFACSKSYFFL
GRHLSYPIALEGALKLKEISYVHAEGFAAGELKHGPIALLDEGAPVVAIATKGQTYEKMLSNIKEVKARDAYVIAVANIN
DTEIGKYADVVLRVPSCDELLAPLLSVVVLQLLAYYTALARDCAIDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=34.6433770014556, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=34.1074020319303, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI29570798, Length=207, Percent_Identity=30.9178743961353, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790167, Length=625, Percent_Identity=45.28, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1788651, Length=198, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532897, Length=491, Percent_Identity=32.1792260692464, Blast_Score=253, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=34.8027842227378, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=34.1860465116279, Blast_Score=251, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6322745, Length=453, Percent_Identity=35.3200883002208, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=441, Percent_Identity=29.0249433106576, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=209, Percent_Identity=43.5406698564593, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=33.1884057971015, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_METMA (Q8Q038)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632324.1
- ProteinModelPortal:   Q8Q038
- SMR:   Q8Q038
- GeneID:   1478642
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0300
- NMPDR:   fig|192952.1.peg.300
- HOGENOM:   HBG645312
- OMA:   ENDNPID
- ProtClustDB:   PRK00331
- BioCyc:   MMAZ192952:MM0300-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67596; Mature: 67596

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 613-613

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYAGRNAAAPVIIESLKKLEYRGYDSAGVTVLGSGVETYKAVGKIINLESEIPKN
CCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCHHHCCCC
LKGAIGIGHTRWATHGRPSTENAHPHNSGGNPVKISLVHNGIIENYMALKERLIGEGYEF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCCCC
KSETDTEVIAHLLHKHIYGSPDGKEARNNLLAGLREALKEIEGSYALAVISADEQGKLVL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEE
ARKDSPLVIGLGKGENFAASDVTAFLIHTRDVIFVDDFETAVLTPDSVEIFDREGKLKEK
EECCCCEEEEECCCCCCCHHHHEEEEEEECCEEEEECCCEEEECCCCCEEECCCCCHHHH
KIEKIEWDFEAAEKAGYEHFMLKEIHEQVSAIHNTLAGKVSELEGAIYLKELNLNDDEIK
HHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
KLSRVQILACGTSWHAGLLGKYLFEQLAGIHCDIDICSEYRYRNPVMHEGTLAIAITQSG
HHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCC
ETADTLAAVREIMSYNCPTLAITNVVGSTITREANSVLYTRAGPEIGVAATKTFSTQLIL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEHHHHHHHHH
LYLLAVKFALVRGKLSPDYVKSFITEIRKVPGEIQQILNQKEVIRECAENFACSKSYFFL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEH
GRHLSYPIALEGALKLKEISYVHAEGFAAGELKHGPIALLDEGAPVVAIATKGQTYEKML
HHCCCCCEEECCCEEHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHH
SNIKEVKARDAYVIAVANINDTEIGKYADVVLRVPSCDELLAPLLSVVVLQLLAYYTALA
HHHHHHHCCCEEEEEEECCCCCCCCCCEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAIDKPRNLAKSVTVE
HHHCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYAGRNAAAPVIIESLKKLEYRGYDSAGVTVLGSGVETYKAVGKIINLESEIPKN
CCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHCCHHHCCCC
LKGAIGIGHTRWATHGRPSTENAHPHNSGGNPVKISLVHNGIIENYMALKERLIGEGYEF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCCCC
KSETDTEVIAHLLHKHIYGSPDGKEARNNLLAGLREALKEIEGSYALAVISADEQGKLVL
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEE
ARKDSPLVIGLGKGENFAASDVTAFLIHTRDVIFVDDFETAVLTPDSVEIFDREGKLKEK
EECCCCEEEEECCCCCCCHHHHEEEEEEECCEEEEECCCEEEECCCCCEEECCCCCHHHH
KIEKIEWDFEAAEKAGYEHFMLKEIHEQVSAIHNTLAGKVSELEGAIYLKELNLNDDEIK
HHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHH
KLSRVQILACGTSWHAGLLGKYLFEQLAGIHCDIDICSEYRYRNPVMHEGTLAIAITQSG
HHHHEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCC
ETADTLAAVREIMSYNCPTLAITNVVGSTITREANSVLYTRAGPEIGVAATKTFSTQLIL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEHHHHHHHHH
LYLLAVKFALVRGKLSPDYVKSFITEIRKVPGEIQQILNQKEVIRECAENFACSKSYFFL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEH
GRHLSYPIALEGALKLKEISYVHAEGFAAGELKHGPIALLDEGAPVVAIATKGQTYEKML
HHCCCCCEEECCCEEHHHHHEEECCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHH
SNIKEVKARDAYVIAVANINDTEIGKYADVVLRVPSCDELLAPLLSVVVLQLLAYYTALA
HHHHHHHCCCEEEEEEECCCCCCCCCCEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAIDKPRNLAKSVTVE
HHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824