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The map label for this gene is glmU [H]

Identifier: 21226401

GI number: 21226401

Start: 399676

End: 400908

Strand: Direct

Name: glmU [H]

Synonym: MM_0299

Alternate gene names: 21226401

Gene position: 399676-400908 (Clockwise)

Preceding gene: 21226392

Following gene: 21226402

Centisome position: 9.76

GC content: 43.88

Gene sequence:

>1233_bases
ATGTTTTTTAACTCTATGAAAGCTATTATCCTCGCAGCAGGGGAAGGACTGCGCTGCAGGCCTCTTACACTTACTCGTTC
CAAAGTAATGCTTCCTGTAGCTAACAGGCCCATTCTGGAACATGTCATATCTTCGCTTGAAAAAAACGAAATCAAAGAAA
TCATCCTGGTTGTCGGGTATGAAAAAGAGCGCATCATGAACTATTTTGAAGACGGGCTTAATTTCGGGGTAAACATATCA
TATGTGGAGCAAAAGGCCCAGCTTGGAACAGCTCATGCAATTGAGCAGGCGAAAAAACTGATAGGGCCCGAAGATTCCGA
ATTTCTTGTTTTGAACGGGGACAACCTTGTAGAGCCTAAAACCATCGCCGACCTCCTTAATAACTATGAAGGTGATGCAA
GCCTCTTAACCGTAAGAATGGAAGATACGGCAGGTTATGGAGTGGTATTGAAAGAAAAGAAGAAAGTCACCCAGATTCTG
GAAAAAAGGCCCGGAGGCTTAAGCCGCCTTGTAAATACAGGAATTTATATTTTTACGCCGCAGGTCTTTGAAACCATTGA
AAAGACCCCAATATCCGAAAACGGAGAATATGCAATAACCGACACTCTCCAGCTTATGATCGATGAGGGGAAAATGGTTA
CTTCAATCCCTACAGAATCAAAATGGCTGGACGCGGTTCACTCGTGGGACCTCCTGAAAGCGAATGCAACCGTATTAAAT
GCCTCCAAAAACCTGAAGCAGGAAGGAGAGCTCGAAGAAGGAGTAATAATCCGCGGAAATGTCGCAATAGGGAAAAACAC
AATAATTCGTTCCGGAACCTATATTGTAGGTCCCGTTGTAATCGGGGAAAACTGTGATATAGGACCTAACGTAGTAATTT
TGCCCTCCACTACTATAGGAGACAACGTGTCCATAAGGTCCTTTACCGAAATACAGAACAGCATCATAATGAATGACTGC
AGGATTTCTTCCCATGGACAGATTTCAAATTCTATAATTGGAAGCAATAATACACTTGGCCCAGGTTTTACCGCAGAGGA
AAAGGAAAACCTTGAGATAAACATAAACTGCAAGGTCCATAAAGCCCCAAAGCTCGGCACTATACTCGGGGACGACAACC
GCATAGGAGGCAGAGTGCTTGTTAAAGCCGGAGTAATGATAGCGGTAAACTGTCAGGTAGAGTCCGGAAATACAATTTAC
AGAGACCTGTCCCGTGATTCGGTGGTCCTCTAA

Upstream 100 bases:

>100_bases
TTGTATATTATATACAATGTCTTTAAACAGTCTTTTTGTATAAATATAGTTTTATATATTAATCCATCAGGTTTTGAAGG
GAATGTATAAATTCTAAAAA

Downstream 100 bases:

>100_bases
GCTCGTAAGAAGGAGATAAAAAATGTGTGGAATTGTAGGGTATGCAGGGCGAAATGCTGCTGCGCCGGTTATAATAGAAT
CTCTTAAAAAACTCGAATAC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MFFNSMKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNEIKEIILVVGYEKERIMNYFEDGLNFGVNIS
YVEQKAQLGTAHAIEQAKKLIGPEDSEFLVLNGDNLVEPKTIADLLNNYEGDASLLTVRMEDTAGYGVVLKEKKKVTQIL
EKRPGGLSRLVNTGIYIFTPQVFETIEKTPISENGEYAITDTLQLMIDEGKMVTSIPTESKWLDAVHSWDLLKANATVLN
ASKNLKQEGELEEGVIIRGNVAIGKNTIIRSGTYIVGPVVIGENCDIGPNVVILPSTTIGDNVSIRSFTEIQNSIIMNDC
RISSHGQISNSIIGSNNTLGPGFTAEEKENLEININCKVHKAPKLGTILGDDNRIGGRVLVKAGVMIAVNCQVESGNTIY
RDLSRDSVVL

Sequences:

>Translated_410_residues
MFFNSMKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNEIKEIILVVGYEKERIMNYFEDGLNFGVNIS
YVEQKAQLGTAHAIEQAKKLIGPEDSEFLVLNGDNLVEPKTIADLLNNYEGDASLLTVRMEDTAGYGVVLKEKKKVTQIL
EKRPGGLSRLVNTGIYIFTPQVFETIEKTPISENGEYAITDTLQLMIDEGKMVTSIPTESKWLDAVHSWDLLKANATVLN
ASKNLKQEGELEEGVIIRGNVAIGKNTIIRSGTYIVGPVVIGENCDIGPNVVILPSTTIGDNVSIRSFTEIQNSIIMNDC
RISSHGQISNSIIGSNNTLGPGFTAEEKENLEININCKVHKAPKLGTILGDDNRIGGRVLVKAGVMIAVNCQVESGNTIY
RDLSRDSVVL
>Mature_410_residues
MFFNSMKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNEIKEIILVVGYEKERIMNYFEDGLNFGVNIS
YVEQKAQLGTAHAIEQAKKLIGPEDSEFLVLNGDNLVEPKTIADLLNNYEGDASLLTVRMEDTAGYGVVLKEKKKVTQIL
EKRPGGLSRLVNTGIYIFTPQVFETIEKTPISENGEYAITDTLQLMIDEGKMVTSIPTESKWLDAVHSWDLLKANATVLN
ASKNLKQEGELEEGVIIRGNVAIGKNTIIRSGTYIVGPVVIGENCDIGPNVVILPSTTIGDNVSIRSFTEIQNSIIMNDC
RISSHGQISNSIIGSNNTLGPGFTAEEKENLEININCKVHKAPKLGTILGDDNRIGGRVLVKAGVMIAVNCQVESGNTIY
RDLSRDSVVL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=342, Percent_Identity=30.1169590643275, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI11761619, Length=342, Percent_Identity=30.1169590643275, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI31881779, Length=366, Percent_Identity=23.4972677595628, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI45447090, Length=366, Percent_Identity=23.4972677595628, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1790168, Length=461, Percent_Identity=25.8134490238612, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788351, Length=235, Percent_Identity=28.0851063829787, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790224, Length=248, Percent_Identity=28.6290322580645, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788355, Length=245, Percent_Identity=26.1224489795918, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787488, Length=248, Percent_Identity=23.7903225806452, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=342, Percent_Identity=29.5321637426901, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17509979, Length=407, Percent_Identity=24.0786240786241, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17509981, Length=392, Percent_Identity=23.469387755102, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=385, Percent_Identity=28.5714285714286, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21355443, Length=342, Percent_Identity=30.1169590643275, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644084, Length=342, Percent_Identity=30.1169590643275, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653912, Length=374, Percent_Identity=25.1336898395722, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 44853; Mature: 44853

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFNSMKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNEIKEIILVVGY
CCCCCEEEEEEECCCCCEEEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECC
EKERIMNYFEDGLNFGVNISYVEQKAQLGTAHAIEQAKKLIGPEDSEFLVLNGDNLVEPK
CHHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHH
TIADLLNNYEGDASLLTVRMEDTAGYGVVLKEKKKVTQILEKRPGGLSRLVNTGIYIFTP
HHHHHHHCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHCCCHHHHHHHCCEEEEEH
QVFETIEKTPISENGEYAITDTLQLMIDEGKMVTSIPTESKWLDAVHSWDLLKANATVLN
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCEEEECCCCHHHHHHHHCCCEEECCCEEEE
ASKNLKQEGELEEGVIIRGNVAIGKNTIIRSGTYIVGPVVIGENCDIGPNVVILPSTTIG
CCCCCCCCCCCCCCEEEEECEEECCCEEEECCCEEEEEEEECCCCCCCCCEEEEECCCCC
DNVSIRSFTEIQNSIIMNDCRISSHGQISNSIIGSNNTLGPGFTAEEKENLEININCKVH
CCCEEHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEEE
KAPKLGTILGDDNRIGGRVLVKAGVMIAVNCQVESGNTIYRDLSRDSVVL
CCCCCCEEECCCCCCCCEEEEECCEEEEEEEEECCCCEEEEECCCCCCCC
>Mature Secondary Structure
MFFNSMKAIILAAGEGLRCRPLTLTRSKVMLPVANRPILEHVISSLEKNEIKEIILVVGY
CCCCCEEEEEEECCCCCEEEEEEEECCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECC
EKERIMNYFEDGLNFGVNISYVEQKAQLGTAHAIEQAKKLIGPEDSEFLVLNGDNLVEPK
CHHHHHHHHHHHCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCHH
TIADLLNNYEGDASLLTVRMEDTAGYGVVLKEKKKVTQILEKRPGGLSRLVNTGIYIFTP
HHHHHHHCCCCCCEEEEEEEECCCCCEEEEECHHHHHHHHHHCCCHHHHHHHCCEEEEEH
QVFETIEKTPISENGEYAITDTLQLMIDEGKMVTSIPTESKWLDAVHSWDLLKANATVLN
HHHHHHHHCCCCCCCCEEEEEEEEEEEECCCEEEECCCCHHHHHHHHCCCEEECCCEEEE
ASKNLKQEGELEEGVIIRGNVAIGKNTIIRSGTYIVGPVVIGENCDIGPNVVILPSTTIG
CCCCCCCCCCCCCCEEEEECEEECCCEEEECCCEEEEEEEECCCCCCCCCEEEEECCCCC
DNVSIRSFTEIQNSIIMNDCRISSHGQISNSIIGSNNTLGPGFTAEEKENLEININCKVH
CCCEEHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEEE
KAPKLGTILGDDNRIGGRVLVKAGVMIAVNCQVESGNTIYRDLSRDSVVL
CCCCCCEEECCCCCCCCEEEEECCEEEEEEEEECCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]