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The map label for this gene is thrC [H]

Identifier: 21226384

GI number: 21226384

Start: 378966

End: 380183

Strand: Direct

Name: thrC [H]

Synonym: MM_0282

Alternate gene names: 21226384

Gene position: 378966-380183 (Clockwise)

Preceding gene: 21226383

Following gene: 21226385

Centisome position: 9.25

GC content: 49.01

Gene sequence:

>1218_bases
ATGTATCATCTAAAATGTATCGAGTGCGGTGCAGAGTATTCAAAAGATGAAGTAATCTATACATGCAGCAAATGCGATGG
GCTGCTTGATGTTATTTATGATTATTCCTCAATTAAACTCGACATGGAAAAATTAAAGACCGAATGTCCTTCGGTCTGGA
AATATGCAGAACTTCTCCCCATAGAAAGAGAACCTGTGACCATACATGAAGGCGGGACCCCACTTTACAGATGCGATCGC
CTTGCCGAAAAGATAGGGATTAAAGAACTCTATGTAAAACATGAAGGAATGAACCCGACTGGCTCATTTAAAGATAGAGG
GATGACTGTTGGGGTTACAAAAGCACTTGAACTCGGAATGAGTACCGTCGCCTGTGCATCAACCGGGAACACGTCGGCAG
CCCTTGCAATCTATGGGGCAAAAGCAGGAATACCTGTGGTTGTGCTTCTTCCGGCTGGAAAAGTTGCCCTTGGAAAGGTA
GCCCAGGCACTTATGCACGGGGCAAAAGTCCTCAGCATCCGCGGAAACTTTGATGATGCACTCGCTCTTGTGCGCACTCT
CTGCTCCCAGGAAAAGATCTACCTCTTAAACTCGATCAACCCTTACAGGCTGGAAGGCCAGAAGACCATCGGCTTCGAGA
TTGCAGACCAGCTCGGCTTCAAAGTTCCTGACAGGATTGTCCTGCCCGTAGGAAATGCAGGCAATATCACTGCTATCTAC
AAGGGTTTCAGGGAGTTCAAGCTCCTTGGCATCACGGACTCCCTCCCGAAGATGACGGGAATTCAGGCAGCAGGCTCCTG
CCCCATAGTAAAAGCCATTAAAAACGGGGCTCCGGAAATCACTCCCGAAGAGAACCCGGAGACGGTTGCAACGGCAATCA
GGATAGGAAACCCTGTGAACGCAACAAAAGCCCTGAACGCTATAAGGGAATCCGGCGGTACTGCGGAGTCCGTAACTGAT
GAAGAAATCCTTGCAGCCCAGAAAGACCTTGCAAGGCTTGAGGGTATAGGAGTCGAACCTGCAAGTGCAGCCTCGGTAGC
TGGTCTTAAGAAACTCGTTGACATGGGAGTCATAGGCAGGGACGAAACAGTAGTCTGCATTACCACAGGCCACCTCCTTA
AAGACCCCCAGACCGTTATTGACATCTGTGAGGAACCTACTGTCGTTGATGCAAACATCGAGTCCATCCGGGAAGCGATT
TTCGGGAAGGGAAAATAA

Upstream 100 bases:

>100_bases
AATCCGAAGTCCGGGTTATATTTACTACTTTAAATTTAGATCGGGTCTGAACAGGGTCCCGGCGTTCAAAAAATTTGAAA
TCACATACAGGAGCAATTTA

Downstream 100 bases:

>100_bases
AGCCTGAAGGACAATCTGGCTTAAAAAAACAATATGCGGCAAGAAACTGCAACTGTATTAAAGGCCCTTTCGGAAGGATT
CGAAGATAAGTACTAAGATA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MYHLKCIECGAEYSKDEVIYTCSKCDGLLDVIYDYSSIKLDMEKLKTECPSVWKYAELLPIEREPVTIHEGGTPLYRCDR
LAEKIGIKELYVKHEGMNPTGSFKDRGMTVGVTKALELGMSTVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKV
AQALMHGAKVLSIRGNFDDALALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLGFKVPDRIVLPVGNAGNITAIY
KGFREFKLLGITDSLPKMTGIQAAGSCPIVKAIKNGAPEITPEENPETVATAIRIGNPVNATKALNAIRESGGTAESVTD
EEILAAQKDLARLEGIGVEPASAASVAGLKKLVDMGVIGRDETVVCITTGHLLKDPQTVIDICEEPTVVDANIESIREAI
FGKGK

Sequences:

>Translated_405_residues
MYHLKCIECGAEYSKDEVIYTCSKCDGLLDVIYDYSSIKLDMEKLKTECPSVWKYAELLPIEREPVTIHEGGTPLYRCDR
LAEKIGIKELYVKHEGMNPTGSFKDRGMTVGVTKALELGMSTVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKV
AQALMHGAKVLSIRGNFDDALALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLGFKVPDRIVLPVGNAGNITAIY
KGFREFKLLGITDSLPKMTGIQAAGSCPIVKAIKNGAPEITPEENPETVATAIRIGNPVNATKALNAIRESGGTAESVTD
EEILAAQKDLARLEGIGVEPASAASVAGLKKLVDMGVIGRDETVVCITTGHLLKDPQTVIDICEEPTVVDANIESIREAI
FGKGK
>Mature_405_residues
MYHLKCIECGAEYSKDEVIYTCSKCDGLLDVIYDYSSIKLDMEKLKTECPSVWKYAELLPIEREPVTIHEGGTPLYRCDR
LAEKIGIKELYVKHEGMNPTGSFKDRGMTVGVTKALELGMSTVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKV
AQALMHGAKVLSIRGNFDDALALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLGFKVPDRIVLPVGNAGNITAIY
KGFREFKLLGITDSLPKMTGIQAAGSCPIVKAIKNGAPEITPEENPETVATAIRIGNPVNATKALNAIRESGGTAESVTD
EEILAAQKDLARLEGIGVEPASAASVAGLKKLVDMGVIGRDETVVCITTGHLLKDPQTVIDICEEPTVVDANIESIREAI
FGKGK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. Does not catalyze the conversion of O-acetyl-L- homoserine into threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1790207, Length=320, Percent_Identity=26.875, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=166, Percent_Identity=36.144578313253, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355833, Length=132, Percent_Identity=32.5757575757576, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 43282; Mature: 43282

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHLKCIECGAEYSKDEVIYTCSKCDGLLDVIYDYSSIKLDMEKLKTECPSVWKYAELLP
CCEEEEEECCCCCCCCCEEEEEHHCCHHHHHHHCHHHHEEEHHHHHHHCHHHHHHHHHCC
IEREPVTIHEGGTPLYRCDRLAEKIGIKELYVKHEGMNPTGSFKDRGMTVGVTKALELGM
CCCCCEEEECCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCCCEEEEHHHHHHHCC
STVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKVAQALMHGAKVLSIRGNFDDA
HHEEEECCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHH
LALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLGFKVPDRIVLPVGNAGNITAIY
HHHHHHHHCCCCEEEEECCCCEEECCCEEECEEEHHHCCCCCCCEEEEEECCCCCCHHHH
KGFREFKLLGITDSLPKMTGIQAAGSCPIVKAIKNGAPEITPEENPETVATAIRIGNPVN
HCHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHEECCCCCC
ATKALNAIRESGGTAESVTDEEILAAQKDLARLEGIGVEPASAASVAGLKKLVDMGVIGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
DETVVCITTGHLLKDPQTVIDICEEPTVVDANIESIREAIFGKGK
CCEEEEEECCCHHCCCHHHHHHHCCCCEEECCHHHHHHHHCCCCC
>Mature Secondary Structure
MYHLKCIECGAEYSKDEVIYTCSKCDGLLDVIYDYSSIKLDMEKLKTECPSVWKYAELLP
CCEEEEEECCCCCCCCCEEEEEHHCCHHHHHHHCHHHHEEEHHHHHHHCHHHHHHHHHCC
IEREPVTIHEGGTPLYRCDRLAEKIGIKELYVKHEGMNPTGSFKDRGMTVGVTKALELGM
CCCCCEEEECCCCCHHHHHHHHHHHCHHHEEEEECCCCCCCCCCCCCEEEEHHHHHHHCC
STVACASTGNTSAALAIYGAKAGIPVVVLLPAGKVALGKVAQALMHGAKVLSIRGNFDDA
HHEEEECCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHH
LALVRTLCSQEKIYLLNSINPYRLEGQKTIGFEIADQLGFKVPDRIVLPVGNAGNITAIY
HHHHHHHHCCCCEEEEECCCCEEECCCEEECEEEHHHCCCCCCCEEEEEECCCCCCHHHH
KGFREFKLLGITDSLPKMTGIQAAGSCPIVKAIKNGAPEITPEENPETVATAIRIGNPVN
HCHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHEECCCCCC
ATKALNAIRESGGTAESVTDEEILAAQKDLARLEGIGVEPASAASVAGLKKLVDMGVIGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
DETVVCITTGHLLKDPQTVIDICEEPTVVDANIESIREAIFGKGK
CCEEEEEECCCHHCCCHHHHHHHCCCCEEECCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]