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The map label for this gene is 21226348

Identifier: 21226348

GI number: 21226348

Start: 327684

End: 328853

Strand: Reverse

Name: 21226348

Synonym: MM_0246

Alternate gene names: NA

Gene position: 328853-327684 (Counterclockwise)

Preceding gene: 21226349

Following gene: 21226347

Centisome position: 8.03

GC content: 47.44

Gene sequence:

>1170_bases
GTGTGGAGCATTAAAAATATGGATCTGGAAGATACCCTTCTGATGATGCCTGGTCCCGTATCTGTTGCACCCAGAGTGCT
CAGGGCGATGTCAAAACCGATGATCAATCACCGGAGTGCCGAATTTGCCGGAATTTATACTGATTGCAGGGGAATTCTTG
CAGATGTTTTCCAGACAAAAAATGACATCTTCTTACTCAGCGGCTCCGGGACTGCAGGAATGGAAGCTGCTGTCGGGTCT
GTAGCCGGAAGCGGGGAAAAAGTCATTGCCATAGAAAACGGAAAATTCGGAGAGCGCTTTAAAGACCTCGCAGCTCTTTA
TGCTGAATTAGTGCCGCTGGAATTTGAATGGGGCCTTCCTGTTGACCTCGAAAAGGTTAAGGAGAAGCTCGAAGAAGGGG
CAAAAGCCATTACCCTTGTCCACAATGAGACCTCTGCAGGCATTATGAACCCTGCTGCAGAAATCGGCAAACTTGCTAAA
AAATACGATGCCCTTTTTATAATGGACGGTGTAACCTCTCTTGGGGGAGATGAAGTCAAAGTCGATGAATGGGGTGTTGA
CATTGCAATCGTAGGCTCACAGAAATGCTTTGCAGCTCCACCGGGAATGGCAGCCGTTTCAGTAAGCGAAAAAGCCTTTG
AGGCTATGAACTGCATGAAGAAGAGGCTCTACTATAATGACCTCAAAGCATATAAAAAGAGCGGGGACAAACCCAGGCCG
GAAACACCTTACACACCTGCGATTCCTCTTTTCTATGCACTTCAGGAAGCCCTTCACATCGTAAAAGAAGAGGGAATGGA
AGCCAGAATCAAAAGGCACAGGACCCTTTCAGAAGCTGTAAGGGCAGCAGCTGGTGCATTGAATATAGAGATGTTCCCTC
AGCTCAATGAGTACAGCCAGTACTCCAACACAATCACAGCATTGAAATCCCCTGCAGGGATTGACGGAGAAGATATCAAA
AATGATATGAAGAAGCGCGGCGTAATCATCGCTGGCGGGCAGGAACGCTTGAAGAGCAAGATTTTCAGGATTGGAAACAT
GGGTAATGTAACTGCAAGGGACGTTCTATCCACTATCCAGCAGCTGGAAATCGTGCTTCATAAGCACGGTTATATTGACA
GCGTGGGAGCAGGTACTGAAGCTGCAACACGCGTTATTGACAGGCTATGA

Upstream 100 bases:

>100_bases
ATTACCCTGAATTATTTCGGGATTGCATGATTGAAAATTACAGGTTCACTAAGTTTTCCCAATAAAAAACAAACAAAATT
GTGAGTTAATCTTTGAAAAA

Downstream 100 bases:

>100_bases
GAGGATTTTAAAAATTCTCCATGCCAGAGTTTATAAACGTTTCAGGAATACCAGAAGAACATATCTTAAATTCCGATCGG
ATTCACATGCCTACAATAGG

Product: Serine-pyruvate aminotransferase

Products: 3-hydroxypyruvate; L-alanine

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MWSIKNMDLEDTLLMMPGPVSVAPRVLRAMSKPMINHRSAEFAGIYTDCRGILADVFQTKNDIFLLSGSGTAGMEAAVGS
VAGSGEKVIAIENGKFGERFKDLAALYAELVPLEFEWGLPVDLEKVKEKLEEGAKAITLVHNETSAGIMNPAAEIGKLAK
KYDALFIMDGVTSLGGDEVKVDEWGVDIAIVGSQKCFAAPPGMAAVSVSEKAFEAMNCMKKRLYYNDLKAYKKSGDKPRP
ETPYTPAIPLFYALQEALHIVKEEGMEARIKRHRTLSEAVRAAAGALNIEMFPQLNEYSQYSNTITALKSPAGIDGEDIK
NDMKKRGVIIAGGQERLKSKIFRIGNMGNVTARDVLSTIQQLEIVLHKHGYIDSVGAGTEAATRVIDRL

Sequences:

>Translated_389_residues
MWSIKNMDLEDTLLMMPGPVSVAPRVLRAMSKPMINHRSAEFAGIYTDCRGILADVFQTKNDIFLLSGSGTAGMEAAVGS
VAGSGEKVIAIENGKFGERFKDLAALYAELVPLEFEWGLPVDLEKVKEKLEEGAKAITLVHNETSAGIMNPAAEIGKLAK
KYDALFIMDGVTSLGGDEVKVDEWGVDIAIVGSQKCFAAPPGMAAVSVSEKAFEAMNCMKKRLYYNDLKAYKKSGDKPRP
ETPYTPAIPLFYALQEALHIVKEEGMEARIKRHRTLSEAVRAAAGALNIEMFPQLNEYSQYSNTITALKSPAGIDGEDIK
NDMKKRGVIIAGGQERLKSKIFRIGNMGNVTARDVLSTIQQLEIVLHKHGYIDSVGAGTEAATRVIDRL
>Mature_389_residues
MWSIKNMDLEDTLLMMPGPVSVAPRVLRAMSKPMINHRSAEFAGIYTDCRGILADVFQTKNDIFLLSGSGTAGMEAAVGS
VAGSGEKVIAIENGKFGERFKDLAALYAELVPLEFEWGLPVDLEKVKEKLEEGAKAITLVHNETSAGIMNPAAEIGKLAK
KYDALFIMDGVTSLGGDEVKVDEWGVDIAIVGSQKCFAAPPGMAAVSVSEKAFEAMNCMKKRLYYNDLKAYKKSGDKPRP
ETPYTPAIPLFYALQEALHIVKEEGMEARIKRHRTLSEAVRAAAGALNIEMFPQLNEYSQYSNTITALKSPAGIDGEDIK
NDMKKRGVIIAGGQERLKSKIFRIGNMGNVTARDVLSTIQQLEIVLHKHGYIDSVGAGTEAATRVIDRL

Specific function: Unknown

COG id: COG0075

COG function: function code E; Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557289, Length=374, Percent_Identity=31.283422459893, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17536281, Length=352, Percent_Identity=30.3977272727273, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321079, Length=367, Percent_Identity=30.5177111716621, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17530823, Length=363, Percent_Identity=32.7823691460055, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: 2.6.1.51

Molecular weight: Translated: 42359; Mature: 42359

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSIKNMDLEDTLLMMPGPVSVAPRVLRAMSKPMINHRSAEFAGIYTDCRGILADVFQTK
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHCC
NDIFLLSGSGTAGMEAAVGSVAGSGEKVIAIENGKFGERFKDLAALYAELVPLEFEWGLP
CCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEECCCCC
VDLEKVKEKLEEGAKAITLVHNETSAGIMNPAAEIGKLAKKYDALFIMDGVTSLGGDEVK
CCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCEEEEECCHHHCCCCEEE
VDEWGVDIAIVGSQKCFAAPPGMAAVSVSEKAFEAMNCMKKRLYYNDLKAYKKSGDKPRP
EECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETPYTPAIPLFYALQEALHIVKEEGMEARIKRHRTLSEAVRAAAGALNIEMFPQLNEYSQ
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
YSNTITALKSPAGIDGEDIKNDMKKRGVIIAGGQERLKSKIFRIGNMGNVTARDVLSTIQ
HHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
QLEIVLHKHGYIDSVGAGTEAATRVIDRL
HHHHHHHHCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MWSIKNMDLEDTLLMMPGPVSVAPRVLRAMSKPMINHRSAEFAGIYTDCRGILADVFQTK
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHCC
NDIFLLSGSGTAGMEAAVGSVAGSGEKVIAIENGKFGERFKDLAALYAELVPLEFEWGLP
CCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEECCCCC
VDLEKVKEKLEEGAKAITLVHNETSAGIMNPAAEIGKLAKKYDALFIMDGVTSLGGDEVK
CCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCEEEEECCHHHCCCCEEE
VDEWGVDIAIVGSQKCFAAPPGMAAVSVSEKAFEAMNCMKKRLYYNDLKAYKKSGDKPRP
EECCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ETPYTPAIPLFYALQEALHIVKEEGMEARIKRHRTLSEAVRAAAGALNIEMFPQLNEYSQ
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHH
YSNTITALKSPAGIDGEDIKNDMKKRGVIIAGGQERLKSKIFRIGNMGNVTARDVLSTIQ
HHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
QLEIVLHKHGYIDSVGAGTEAATRVIDRL
HHHHHHHHCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-serine; pyruvate

Specific reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]