Click here to switch to the map view.

The map label for this gene is ung

Identifier: 209695969

GI number: 209695969

Start: 2731716

End: 2732390

Strand: Reverse

Name: ung

Synonym: VSAL_I2551

Alternate gene names: 209695969

Gene position: 2732390-2731716 (Counterclockwise)

Preceding gene: 209695970

Following gene: 209695968

Centisome position: 82.17

GC content: 37.93

Gene sequence:

>675_bases
ATGAACACATCTTGGAATGACATTTTAGAAACGGAAAAAGAAAAACCGTATTATCAAGAAATGATGACGTATATAAACGA
AGCACGTTCTCAAGGAAAAAAAATATTCCCCAAAGAAGAGGATGTGTTTACTGCTTTTTCATTGACGCCATTTAATAACG
TTACCGTTGTCATTCTAGGTCAAGATCCCTATCACGGAGAAGGGCAGGCGCATGGGCTGTCTTTTTCTGTATTACCAGGA
GTTAAGATCCCGCCTTCTCTGCGCAATATGTATAAAGAATTAGCAGAAGATATTGAGGGTTTTATTCCACCAACACATGG
TTATTTAGAAAGTTGGGCTGAGCAAGGGGTCTTGTTACTTAATACGGTATTAACCGTTGAAGAATCACAAGCTCATTCTC
ATGCAAAGTTAGGATGGGAAACGTTTACTGACAGCATCATTGAGCAATTAAATGAAAAAAAAGAAGGGATTATTTTCTTA
CTATGGGGGGCTCATGCTCAAAAAAAAGGCATTAATATTGATGCAATGAAGCACTCTATTTTAGTGGCTCCTCATCCTTC
CCCTTTATCGGCAAGAAGAGGTTTTTTTGGTTGTCAGCACTTTTCTAAAACAAATGAATTGCTGCGAGAGAAAAACTTAT
CCGAAATCAACTGGAGTTCAATTACATTGGACTAG

Upstream 100 bases:

>100_bases
TGATCGTTTTAATGGCATTCCTTTAGTATTAGAGACGATAAACCCTGATATTTGGAAGGATGAAATCGCTCAACTTAAAG
AACTCAGTGAGAAAAAATAA

Downstream 100 bases:

>100_bases
TGGTTAAAAGTTGAACTGAAAAGCGGTGCTCCTTTAATAATACGTTAGACTCAAAAGGTAATCACCTGACAGAGTAAGGG
AGGACAGGATGCTTATAGAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNTSWNDILETEKEKPYYQEMMTYINEARSQGKKIFPKEEDVFTAFSLTPFNNVTVVILGQDPYHGEGQAHGLSFSVLPG
VKIPPSLRNMYKELAEDIEGFIPPTHGYLESWAEQGVLLLNTVLTVEESQAHSHAKLGWETFTDSIIEQLNEKKEGIIFL
LWGAHAQKKGINIDAMKHSILVAPHPSPLSARRGFFGCQHFSKTNELLREKNLSEINWSSITLD

Sequences:

>Translated_224_residues
MNTSWNDILETEKEKPYYQEMMTYINEARSQGKKIFPKEEDVFTAFSLTPFNNVTVVILGQDPYHGEGQAHGLSFSVLPG
VKIPPSLRNMYKELAEDIEGFIPPTHGYLESWAEQGVLLLNTVLTVEESQAHSHAKLGWETFTDSIIEQLNEKKEGIIFL
LWGAHAQKKGINIDAMKHSILVAPHPSPLSARRGFFGCQHFSKTNELLREKNLSEINWSSITLD
>Mature_224_residues
MNTSWNDILETEKEKPYYQEMMTYINEARSQGKKIFPKEEDVFTAFSLTPFNNVTVVILGQDPYHGEGQAHGLSFSVLPG
VKIPPSLRNMYKELAEDIEGFIPPTHGYLESWAEQGVLLLNTVLTVEESQAHSHAKLGWETFTDSIIEQLNEKKEGIIFL
LWGAHAQKKGINIDAMKHSILVAPHPSPLSARRGFFGCQHFSKTNELLREKNLSEINWSSITLD

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=52.7522935779816, Blast_Score=238, Evalue=3e-63,
Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=52.7522935779816, Blast_Score=238, Evalue=3e-63,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=59.1743119266055, Blast_Score=286, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17556304, Length=219, Percent_Identity=50.2283105022831, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6323620, Length=242, Percent_Identity=42.1487603305785, Blast_Score=178, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_ALISL (B6EKY3)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263899.1
- GeneID:   6987814
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2551
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25373; Mature: 25373

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSWNDILETEKEKPYYQEMMTYINEARSQGKKIFPKEEDVFTAFSLTPFNNVTVVILG
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEC
QDPYHGEGQAHGLSFSVLPGVKIPPSLRNMYKELAEDIEGFIPPTHGYLESWAEQGVLLL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEE
NTVLTVEESQAHSHAKLGWETFTDSIIEQLNEKKEGIIFLLWGAHAQKKGINIDAMKHSI
HHHHHEEHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCEE
LVAPHPSPLSARRGFFGCQHFSKTNELLREKNLSEINWSSITLD
EECCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEC
>Mature Secondary Structure
MNTSWNDILETEKEKPYYQEMMTYINEARSQGKKIFPKEEDVFTAFSLTPFNNVTVVILG
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEC
QDPYHGEGQAHGLSFSVLPGVKIPPSLRNMYKELAEDIEGFIPPTHGYLESWAEQGVLLL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEE
NTVLTVEESQAHSHAKLGWETFTDSIIEQLNEKKEGIIFLLWGAHAQKKGINIDAMKHSI
HHHHHEEHHHCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCEE
LVAPHPSPLSARRGFFGCQHFSKTNELLREKNLSEINWSSITLD
EECCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA