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The map label for this gene is phoR [H]

Identifier: 209695879

GI number: 209695879

Start: 2628402

End: 2629700

Strand: Reverse

Name: phoR [H]

Synonym: VSAL_I2456

Alternate gene names: 209695879

Gene position: 2629700-2628402 (Counterclockwise)

Preceding gene: 209695880

Following gene: 209695878

Centisome position: 79.08

GC content: 41.34

Gene sequence:

>1299_bases
ATGGTTGAGCGTCTGTCATGGAAAAAGCTGGTTGGAGAATTGGCTTTTTTCTATGTTCCTTGGATTATTGTAGGGTACTT
ATTTGATGCCTTATGGCCATTGTTGTTTCTCGCGTCGTTTATTTTATTGATTTGGCATTTGCACAATCAAATTAAAATGT
CTCGTTGGTTACATGAAGGACGAAAAGCCACTCCGCCCTCAGCTTCTGGCAGTTGGGAGCCTATTTTTGATGAAACTTAT
CGTTTACAAAAACGTCATAAAAAACGCCGTAAAGAGTTATCTGTTTTAATTCGACGATTCCGACAAGGGGCAGAAGCATT
GCCTGATGCCGTGGTGGTATTTCGTCATGAAGGTAACATTGTGTGGTGTAATTCTTTAGCGCAATCGCTATTGGGCTTTC
GTTGGCCTGAAGATTCGGGTCATCCGATAACGAATTTAATTAGACCCCCTGATTTTGTACAGTATTTATTGGCGCAACAA
TTTGATATTCCATTGGATATGCCATCGCCAATTAATTCAGACAAAACCTTAGAAATACGTATCGCACCTTACAGTGAAGG
CGAGTACTTGATGGTGGTGCGTGATGTTACTCAAATCAAGCAGCTCGAAGGCATGCGCCGTAATTTCTTTGCCAATGTAT
CGCATGAGCTACGTACACCAATGACGGTGCTTCGTGGTTATTTAGAAATGTCAGAAGATCCAGACATGCTTGTTGGCCCT
ATGTGGAATAGAGCGCACGGAGTCATGACAGAACAATTAACTCGGATGGAGGGGTTAGTTGAGCAACTATTAACGCTTTC
TAAAATTGAAGCCGCCGCAACATCGATGTTAGAAGATGAAGTTGATGTACCGGCAATGCTTGATATTTTAGAGAAAGAAG
CACAGGCGTTAAGTGGTGATAGAAACCATAATATTACGTTTAATATTGATCGCTTGCTTAAAGTTCAAGGCGATGAAGAT
CAATTACGAAGCGCGATTTCTAATTTGGTATACAACGCGGTTAAGCATACAACGGATGGTGCAAATATCGTCATTGATTG
GCGTCTTTCTTCTGCGGGAGCGAAACTTAAAGTTACGGACAGCGGACAAGGGATTGAAGCGCAACATATTCATCGTTTAA
CCGAGCGTTTTTATCGAGTAGATAAAGCTCGTTCAAGAGAAACTGGTGGCAGTGGTTTAGGATTAGCTATTGTAAAACAT
GCGCTTAGCCATCATGATTCGCAATTAGAAATACAAAGCAAACTGGGTAAAGGGAGCACTTTCTCGTTTGTATTACCGAA
AAAACTCATTCTAAAGTAG

Upstream 100 bases:

>100_bases
AGAAGGGCATGATCGTTTGGTTCAAACGGTTCGTGGTGCTGGCTACCGTTTTTCTGTGCAATGCGCATAACCGTCAATTA
TTAACGTAAAGGTAGGCTAA

Downstream 100 bases:

>100_bases
AGCATAATGAACGGATTTTATAGCACGAAGCGTAAGTGGTATCAGGTACTCACCCCTGTGGCACTGCTTTGGCTATGCGT
TATTAATAATGGTATGGCTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVERLSWKKLVGELAFFYVPWIIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSVLIRRFRQGAEALPDAVVVFRHEGNIVWCNSLAQSLLGFRWPEDSGHPITNLIRPPDFVQYLLAQQ
FDIPLDMPSPINSDKTLEIRIAPYSEGEYLMVVRDVTQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLTRMEGLVEQLLTLSKIEAAATSMLEDEVDVPAMLDILEKEAQALSGDRNHNITFNIDRLLKVQGDED
QLRSAISNLVYNAVKHTTDGANIVIDWRLSSAGAKLKVTDSGQGIEAQHIHRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIQSKLGKGSTFSFVLPKKLILK

Sequences:

>Translated_432_residues
MVERLSWKKLVGELAFFYVPWIIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSVLIRRFRQGAEALPDAVVVFRHEGNIVWCNSLAQSLLGFRWPEDSGHPITNLIRPPDFVQYLLAQQ
FDIPLDMPSPINSDKTLEIRIAPYSEGEYLMVVRDVTQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLTRMEGLVEQLLTLSKIEAAATSMLEDEVDVPAMLDILEKEAQALSGDRNHNITFNIDRLLKVQGDED
QLRSAISNLVYNAVKHTTDGANIVIDWRLSSAGAKLKVTDSGQGIEAQHIHRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIQSKLGKGSTFSFVLPKKLILK
>Mature_432_residues
MVERLSWKKLVGELAFFYVPWIIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSVLIRRFRQGAEALPDAVVVFRHEGNIVWCNSLAQSLLGFRWPEDSGHPITNLIRPPDFVQYLLAQQ
FDIPLDMPSPINSDKTLEIRIAPYSEGEYLMVVRDVTQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLTRMEGLVEQLLTLSKIEAAATSMLEDEVDVPAMLDILEKEAQALSGDRNHNITFNIDRLLKVQGDED
QLRSAISNLVYNAVKHTTDGANIVIDWRLSSAGAKLKVTDSGQGIEAQHIHRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIQSKLGKGSTFSFVLPKKLILK

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=434, Percent_Identity=58.5253456221198, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=29.4820717131474, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=31.1787072243346, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=31.9148936170213, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=220, Percent_Identity=29.5454545454545, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=28.3185840707965, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788713, Length=392, Percent_Identity=23.7244897959184, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=29.3333333333333, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788549, Length=354, Percent_Identity=22.5988700564972, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=235, Percent_Identity=31.4893617021277, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=26.8181818181818, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=385, Percent_Identity=24.6753246753247, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=24.8908296943231, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=217, Percent_Identity=26.7281105990783, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=26.5217391304348, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=247, Percent_Identity=26.7206477732794, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789403, Length=216, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=28.2608695652174, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49339; Mature: 49339

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERLSWKKLVGELAFFYVPWIIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKATPPSASGSWEPIFDETYRLQKRHKKRRKELSVLIRRFRQGAEALPDAVVVFRHEGNI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VWCNSLAQSLLGFRWPEDSGHPITNLIRPPDFVQYLLAQQFDIPLDMPSPINSDKTLEIR
EEHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
IAPYSEGEYLMVVRDVTQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEECC
MWNRAHGVMTEQLTRMEGLVEQLLTLSKIEAAATSMLEDEVDVPAMLDILEKEAQALSGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
RNHNITFNIDRLLKVQGDEDQLRSAISNLVYNAVKHTTDGANIVIDWRLSSAGAKLKVTD
CCCCEEEEHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEC
SGQGIEAQHIHRLTERFYRVDKARSRETGGSGLGLAIVKHALSHHDSQLEIQSKLGKGST
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCE
FSFVLPKKLILK
EEEECCHHHHCC
>Mature Secondary Structure
MVERLSWKKLVGELAFFYVPWIIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKATPPSASGSWEPIFDETYRLQKRHKKRRKELSVLIRRFRQGAEALPDAVVVFRHEGNI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VWCNSLAQSLLGFRWPEDSGHPITNLIRPPDFVQYLLAQQFDIPLDMPSPINSDKTLEIR
EEHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEE
IAPYSEGEYLMVVRDVTQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEECC
MWNRAHGVMTEQLTRMEGLVEQLLTLSKIEAAATSMLEDEVDVPAMLDILEKEAQALSGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
RNHNITFNIDRLLKVQGDEDQLRSAISNLVYNAVKHTTDGANIVIDWRLSSAGAKLKVTD
CCCCEEEEHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEC
SGQGIEAQHIHRLTERFYRVDKARSRETGGSGLGLAIVKHALSHHDSQLEIQSKLGKGST
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCE
FSFVLPKKLILK
EEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]