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The map label for this gene is nhaA

Identifier: 209695476

GI number: 209695476

Start: 2170673

End: 2171821

Strand: Direct

Name: nhaA

Synonym: VSAL_I2026

Alternate gene names: 209695476

Gene position: 2170673-2171821 (Clockwise)

Preceding gene: 209695475

Following gene: 209695478

Centisome position: 65.28

GC content: 39.43

Gene sequence:

>1149_bases
ATGAGTGATGTTATTAAGAATTTTTTCAAATTAGAATCTGCAGGTGGGATTCTTTTAGTGATTGCAGCTGCAATTGCGAT
GATTATTGCAAACTCTTCTTTTGCGCCAATGTACGATACATTTTTACATACTTATCTTGGTGGCATGTCGGTGTCACATT
GGATCAATGATGGTCTAATGGCTGTTTTCTTCTTATTGATAGGTCTTGAAGTTAAAAGAGAACTTCTTGAAGGCGCTCTT
AAATCAAAAGAAACGGCTATCTTCCCTGCAATTGCTGCTGTTGGTGGCATGCTTGCTCCTGCATTGGTTTATGTTGCGTT
TAATATGGGTGATCCAGAAGCGTTATCTGGTTGGGCTATTCCTGCTGCCACTGATATTGCTTTTGCTTTAGGTATCATGG
CATTACTTGGTAACCGAGTACCTGTAAGCTTAAAAGTCTTTTTACTGGCACTTGCAATCATCGATGACCTCGGTGTTGTT
GTAATTATTGCTTTCTTCTATACCAGTGATTTATCAGTATTAGCACTTGTGATTGGCTTTGTAATGACGGGGATTTTATT
CCTACTAAATTCAAAGCATGTATCTAAAATACGTTGGTATTTATTAGTTGGCTTTATTCTGTGGGTTAGTGTTTTACAAT
CTGGAGTTCATGCGACGTTAGCGGGTGTGGTATTAGGCTTTGCTATTCCTTTAAAAGGTAAAAAAGGCGAGCGTTCACCT
CTAAAACACATGGAACATGCACTTCATCCATATGTTGCTTTTGGTATTTTACCGTTGTTTGCATTCGCGAACGCAGGTAT
TTCATTAGATGGTGTGTCATTAGATAGCTTGACGACAACACTGCCACTGGGTGTCGCGTTAGGTCTGTTCTTAGGTAAGC
CATTAGGTATCTTTAGCTTTAGTTATGTTGCTGTGAAATCAGGTATTGCTAAGTTGCCTGCTGGAGTTAACATGAAGCAC
ATATTCGCGGTTTCAGTTCTTTGTGGTATCGGTTTTACAATGTCGATCTTTATCTCATCACTGGCATTTGGTGGTGCGAA
CCCTGAATTTGATAAATTAGCTCGATTAGGCATCTTAATGGGATCAACCCTAGCGGCAGTTGTTGGTTATATTTTACTGC
ACATTAGCCTACCTAAAAAAGCAGCATAA

Upstream 100 bases:

>100_bases
ATGTTTATGCTCTGAACAAGCGATTATTATTGATATTAAGCAACGGGTAGACTTTCACTATTCGTTTTTCAATAAACTAT
AATTATAAAAAGGGCATCTC

Downstream 100 bases:

>100_bases
GAAATTTAGTTTAAATGAATGCATAAAATACCTCGCTTAGGCGGTAATGCCGTTCACTTAAGGGTGAATGGCATTCTTGT
TTCTGGCATATCGTTGAGGT

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSDVIKNFFKLESAGGILLVIAAAIAMIIANSSFAPMYDTFLHTYLGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGAL
KSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVV
VIIAFFYTSDLSVLALVIGFVMTGILFLLNSKHVSKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGKKGERSP
LKHMEHALHPYVAFGILPLFAFANAGISLDGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYVAVKSGIAKLPAGVNMKH
IFAVSVLCGIGFTMSIFISSLAFGGANPEFDKLARLGILMGSTLAAVVGYILLHISLPKKAA

Sequences:

>Translated_382_residues
MSDVIKNFFKLESAGGILLVIAAAIAMIIANSSFAPMYDTFLHTYLGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGAL
KSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVV
VIIAFFYTSDLSVLALVIGFVMTGILFLLNSKHVSKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGKKGERSP
LKHMEHALHPYVAFGILPLFAFANAGISLDGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYVAVKSGIAKLPAGVNMKH
IFAVSVLCGIGFTMSIFISSLAFGGANPEFDKLARLGILMGSTLAAVVGYILLHISLPKKAA
>Mature_381_residues
SDVIKNFFKLESAGGILLVIAAAIAMIIANSSFAPMYDTFLHTYLGGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALK
SKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAIPAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVV
IIAFFYTSDLSVLALVIGFVMTGILFLLNSKHVSKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGKKGERSPL
KHMEHALHPYVAFGILPLFAFANAGISLDGVSLDSLTTTLPLGVALGLFLGKPLGIFSFSYVAVKSGIAKLPAGVNMKHI
FAVSVLCGIGFTMSIFISSLAFGGANPEFDKLARLGILMGSTLAAVVGYILLHISLPKKAA

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=382, Percent_Identity=57.0680628272251, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_ALISL (B6EHQ0)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263405.1
- GeneID:   6987523
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2026
- HOGENOM:   HBG665619
- OMA:   LIHWIND
- ProtClustDB:   PRK09560
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 40283; Mature: 40152

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x205039b0)-; HASH(0x217c45c8)-; HASH(0x217e7344)-; HASH(0x2119fec8)-; HASH(0x20f77b84)-; HASH(0x217b3388)-; HASH(0x213f034c)-; HASH(0x20c541ec)-; HASH(0x20e1a468)-; HASH(0x20d0e938)-; HASH(0x21404ecc)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVIKNFFKLESAGGILLVIAAAIAMIIANSSFAPMYDTFLHTYLGGMSVSHWINDGLM
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHH
AVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
PAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIAFFYTSDLSVLALVIGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VMTGILFLLNSKHVSKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGKKGERSP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LKHMEHALHPYVAFGILPLFAFANAGISLDGVSLDSLTTTLPLGVALGLFLGKPLGIFSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYVAVKSGIAKLPAGVNMKHIFAVSVLCGIGFTMSIFISSLAFGGANPEFDKLARLGILM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTLAAVVGYILLHISLPKKAA
HHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
SDVIKNFFKLESAGGILLVIAAAIAMIIANSSFAPMYDTFLHTYLGGMSVSHWINDGLM
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHH
AVFFLLIGLEVKRELLEGALKSKETAIFPAIAAVGGMLAPALVYVAFNMGDPEALSGWAI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCC
PAATDIAFALGIMALLGNRVPVSLKVFLLALAIIDDLGVVVIIAFFYTSDLSVLALVIGF
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VMTGILFLLNSKHVSKIRWYLLVGFILWVSVLQSGVHATLAGVVLGFAIPLKGKKGERSP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
LKHMEHALHPYVAFGILPLFAFANAGISLDGVSLDSLTTTLPLGVALGLFLGKPLGIFSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
SYVAVKSGIAKLPAGVNMKHIFAVSVLCGIGFTMSIFISSLAFGGANPEFDKLARLGILM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GSTLAAVVGYILLHISLPKKAA
HHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA