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The map label for this gene is hipA [H]

Identifier: 209695277

GI number: 209695277

Start: 1924351

End: 1925673

Strand: Direct

Name: hipA [H]

Synonym: VSAL_I1802

Alternate gene names: 209695277

Gene position: 1924351-1925673 (Clockwise)

Preceding gene: 209695276

Following gene: 209695282

Centisome position: 57.87

GC content: 37.26

Gene sequence:

>1323_bases
ATGGCTGTATTAATTGCATACATGAATGGTGAGCGTGTTGGAGAATTTACTAAACTCAGTAACGGTGCACATCAGTTTCA
ATACGATAAATCATGGATAGAAAGTACGGTAGGAAGACCCCTGTCATTATCCCTCCCCCTACAATATCCAAAGATAACCA
GTGATTGCGTTATTAATTACTTCGACAACCTATTACCTGATTTGTCAGAAGTCAGAGATCGCATCGTTGCCAGATACCAA
GCTAAATCTCGTCAAACATTCGATTTACTTCATGAAGTTGGTAAAGACAGCGTCGGTGCTATTTCTTTATTAACTAACGA
TGAAGAACCAAATACCAAACAACTGGATTATGATGTTTTAACTCCAGCACGGCTCAAACAAGTACTCTCAGCCTATCAAT
CCAATATTCCATTAGGAATGCTAGAAGATGAATCAGACTTTCGAATTTCGGTTGCCGGAGCACAAGAAAAAACAGCGTTA
CTCAAAATAAATGATGAATGGTGCATACCGAAAGCATCTACCCCAACAACGCATATAATCAAATTACCCATTGGAAAAAT
TCAACAACCTAATGCCACTCTCGATATGAGTGATAGTGTAGAAAATGAATACCTGTGCATCCAATTAGCTAAGAAGTTAG
GATTCAATGTACCTAATGTTGAAATACTTCATTGTGATGGAATAAAAGCCATTGCTGTAGAACGATTTGATCGAAAGTGG
ATTAAAAATAACACCAAGCTATTAAGATTACCGCAAGAAGATATGTGCCAAGCATTTGGATTACCCTCATCAATCAAATA
TGAAACTGATGGAGGCCCAAGTATAAAAACCATTATGGATCTTCTAATGGGCTCAAGCCAATCACTAAAAGATCGTGATG
CTTTTATGCGATTTCAGGTATTTCAATGGTTAATTGGTGCAACAGACGGACACGCAAAAAACTTCTCCATTTTTATTAAT
GCACAAGGCAGTTATCACCTTACGCCCTTTTATGACATTTTATCCGCCTATCCGATCTTAGGTGGTAAAGGGATGAATAT
CCGCTCATTAAAACTGGCAATGGGACTAACTGCATCAAAAGGAAAGAAATACCCTATTGATAAAATATACACACGTCATT
TTATTGATACGGCTAAATCTGTTGGATTTGATACTGCGAGAATGGAAGAGATAATGAAGGAATTTGCGATAAATATGCCT
AAGTCCATTAAGGAATTAGAAGCAGAATTACCAAGCGGTTTTCCAAAGGATATTTCTGGCAGCATATTCAGTAATGCATT
GAGAATGGTAAATAAGATCCGCTTGAGTAATGATTTTCAGTAA

Upstream 100 bases:

>100_bases
AGACTCTCTTTAAGATCCTTCATGCGTTAGAAGTTCATTGTATTATTCAAGAGCAAGTCCCAACAAGTCTCGATGATAAT
CCAGATGATGAGGTATGGTA

Downstream 100 bases:

>100_bases
CGTTGATTTAAGGCCTATCTTTACTCGATAACCAGAGAATATCTAGAATGAATATGATTGTTCTACTGAATGGGAACCTC
TTTACAACACATTTAAATGA

Product: HipA family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LKINDEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKW
IKNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMP
KSIKELEAELPSGFPKDISGSIFSNALRMVNKIRLSNDFQ

Sequences:

>Translated_440_residues
MAVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LKINDEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKW
IKNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMP
KSIKELEAELPSGFPKDISGSIFSNALRMVNKIRLSNDFQ
>Mature_439_residues
AVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQA
KSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALL
KINDEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKWI
KNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFINA
QGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMPK
SIKELEAELPSGFPKDISGSIFSNALRMVNKIRLSNDFQ

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=439, Percent_Identity=62.1867881548975, Blast_Score=580, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 49429; Mature: 49298

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINY
CEEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
FDNLLPDLSEVRDRIVARYQAKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVL
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCC
TPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALLKINDEWCIPKASTPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEE
KLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKW
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
IKNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQV
HHCCCEEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
FQWLIGATDGHAKNFSIFINAQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASK
HHHHHCCCCCCCCEEEEEEECCCCEECCHHHHHHHHCCCCCCCCCCEEEEHEEECCCCCC
GKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMPKSIKELEAELPSGFPKDISG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCH
SIFSNALRMVNKIRLSNDFQ
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVLIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINY
EEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
FDNLLPDLSEVRDRIVARYQAKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYDVL
HHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCC
TPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTALLKINDEWCIPKASTPTTHII
CHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEE
KLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEILHCDGIKAIAVERFDRKW
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHH
IKNNTKLLRLPQEDMCQAFGLPSSIKYETDGGPSIKTIMDLLMGSSQSLKDRDAFMRFQV
HHCCCEEEECCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
FQWLIGATDGHAKNFSIFINAQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASK
HHHHHCCCCCCCCEEEEEEECCCCEECCHHHHHHHHCCCCCCCCCCEEEEHEEECCCCCC
GKKYPIDKIYTRHFIDTAKSVGFDTARMEEIMKEFAINMPKSIKELEAELPSGFPKDISG
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCH
SIFSNALRMVNKIRLSNDFQ
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]