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The map label for this gene is patB [H]

Identifier: 209695111

GI number: 209695111

Start: 1716912

End: 1718084

Strand: Direct

Name: patB [H]

Synonym: VSAL_I1610

Alternate gene names: 209695111

Gene position: 1716912-1718084 (Clockwise)

Preceding gene: 209695110

Following gene: 209695113

Centisome position: 51.63

GC content: 40.92

Gene sequence:

>1173_bases
ATGACAACTTCTTTTAATTGCATTCATAACCGTTGTAATACCGGCTCATTAAAATGGGACTTCATGAAAGAAAAACTCGG
ATTAGACGGCACAGACCGATTACCAATGTGGGTGTCTGATTATGACTTTCAAGCGCCACCACACGTATTAGAAGCACTTC
ATAATCGCATTGACCATGGTATTTTTGGTTATGCAGAACGTAATGAGGATTACTACCAAGCGATCATCACTTGGTATCAA
GAGCAACATCACATTCAAATTGAAAAAGAGTGGATAACGACAGTACACGGCGTATTACCAGGACTTTCAATGGCAATTCA
ATTGCTGACTGAAACCAATGATAAAGTGGTCATGCAAACACCGGGCTATGGCTCGTTTCGTAAAATCGTTGAATTTAATG
ACCGCGTATTGGTTAAGAACCCATTACTTGAACAGCAAGGAACTTACTCACTCGATCTTGTTCACTTAGAATCTTGTTTT
CAACAAGGCGCTAAAGTGATGATCTTCTGTAACCCTCACAACCCTGTTGGTAAAGCATGGTCAAAAGAAGAGATAACCGC
TGTAGCAGAACTATGTCATCAATATGATGTGTGGCTGCTAAGTGATGAGATCTGGGGAGATTTAGCGATGAGAGATAACA
TTTACCATTCAGCGTTATCATTACCAGAAAAGCTACAACAAAAACTGATTGTAGCAACGGCAGCGAGTAAAACATTTGGT
TTGTCTTCTGTGCGTATTTCTAATTTCATGATCCCAAATCAAGAATTAAAAGCACGCTTAGTTCGACGTTTAGATGCTCA
TGGTATGGATGTTTATAATAGCTTGGCAATGTGTGCAGCAACCGCCGCTTATCAAACTTCAGCACCTTGGTTAAATGAAC
TAAAAACGTATCTACAAGAGAACATAAACACCCTATCACGCTTTATTGAAACAGAGTTACCAGAACTAAGCTTTACGCCT
CCAGAAGCGGGGTATTTAGCGTGGGTAGATTGTCGTGCTCTTGGGTTAACAGATAAAGAATTAGAGCTGAAATTAGTTGA
TGCCGGAATAGTCCCAAGCATGGGGATCGCCTTTGGCAGTGAAGGCTCTGGGTTTATTCGTTTAAACCTAGGTTGCCCTC
GTGAAGTGCTAATTCAAGCCATGCAGCGAATTAGCGTTGCGCTGAATAACTAA

Upstream 100 bases:

>100_bases
CGCCATCATTTATGGATTTACTGGCTTTGGCATTGCAAAAGCACCCGTAACTCAAGACAACGACTCACTATCTCCTGTTG
AAGTAAAATAAGGCTATCCC

Downstream 100 bases:

>100_bases
GTGAATAACCATCACGTCTAAAACAAGAAAGCCGCTATATATTAGCGGCTTTTTATCATCATAATTCAAGCAACTGACTG
TCATTTACTGGTTATCTCCA

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTTSFNCIHNRCNTGSLKWDFMKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNEDYYQAIITWYQ
EQHHIQIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVKNPLLEQQGTYSLDLVHLESCF
QQGAKVMIFCNPHNPVGKAWSKEEITAVAELCHQYDVWLLSDEIWGDLAMRDNIYHSALSLPEKLQQKLIVATAASKTFG
LSSVRISNFMIPNQELKARLVRRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENINTLSRFIETELPELSFTP
PEAGYLAWVDCRALGLTDKELELKLVDAGIVPSMGIAFGSEGSGFIRLNLGCPREVLIQAMQRISVALNN

Sequences:

>Translated_390_residues
MTTSFNCIHNRCNTGSLKWDFMKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNEDYYQAIITWYQ
EQHHIQIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVKNPLLEQQGTYSLDLVHLESCF
QQGAKVMIFCNPHNPVGKAWSKEEITAVAELCHQYDVWLLSDEIWGDLAMRDNIYHSALSLPEKLQQKLIVATAASKTFG
LSSVRISNFMIPNQELKARLVRRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENINTLSRFIETELPELSFTP
PEAGYLAWVDCRALGLTDKELELKLVDAGIVPSMGIAFGSEGSGFIRLNLGCPREVLIQAMQRISVALNN
>Mature_389_residues
TTSFNCIHNRCNTGSLKWDFMKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHGIFGYAERNEDYYQAIITWYQE
QHHIQIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQTPGYGSFRKIVEFNDRVLVKNPLLEQQGTYSLDLVHLESCFQ
QGAKVMIFCNPHNPVGKAWSKEEITAVAELCHQYDVWLLSDEIWGDLAMRDNIYHSALSLPEKLQQKLIVATAASKTFGL
SSVRISNFMIPNQELKARLVRRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQENINTLSRFIETELPELSFTPP
EAGYLAWVDCRALGLTDKELELKLVDAGIVPSMGIAFGSEGSGFIRLNLGCPREVLIQAMQRISVALNN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=184, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI56713254, Length=184, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI187936925, Length=329, Percent_Identity=24.6200607902736, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI14211921, Length=329, Percent_Identity=24.6200607902736, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI95147551, Length=166, Percent_Identity=25.9036144578313, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI169881279, Length=166, Percent_Identity=25.9036144578313, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787909, Length=377, Percent_Identity=32.3607427055703, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788722, Length=369, Percent_Identity=23.5772357723577, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788627, Length=248, Percent_Identity=22.9838709677419, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1786816, Length=214, Percent_Identity=20.0934579439252, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=269, Percent_Identity=26.3940520446097, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573069, Length=332, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24646114, Length=332, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573067, Length=332, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573065, Length=332, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44130; Mature: 43999

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSFNCIHNRCNTGSLKWDFMKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHG
CCCCCHHHHCCCCCCCEEHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCC
IFGYAERNEDYYQAIITWYQEQHHIQIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQT
CCCEECCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PGYGSFRKIVEFNDRVLVKNPLLEQQGTYSLDLVHLESCFQQGAKVMIFCNPHNPVGKAW
CCCCHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCC
SKEEITAVAELCHQYDVWLLSDEIWGDLAMRDNIYHSALSLPEKLQQKLIVATAASKTFG
CHHHHHHHHHHHHHCCEEEECHHHHCCHHHHHHHHHHHHCCHHHHHHHEEHEEECCCCCC
LSSVRISNFMIPNQELKARLVRRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQE
CCEEEHHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NINTLSRFIETELPELSFTPPEAGYLAWVDCRALGLTDKELELKLVDAGIVPSMGIAFGS
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEECC
EGSGFIRLNLGCPREVLIQAMQRISVALNN
CCCCEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTSFNCIHNRCNTGSLKWDFMKEKLGLDGTDRLPMWVSDYDFQAPPHVLEALHNRIDHG
CCCCHHHHCCCCCCCEEHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCC
IFGYAERNEDYYQAIITWYQEQHHIQIEKEWITTVHGVLPGLSMAIQLLTETNDKVVMQT
CCCEECCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PGYGSFRKIVEFNDRVLVKNPLLEQQGTYSLDLVHLESCFQQGAKVMIFCNPHNPVGKAW
CCCCHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCC
SKEEITAVAELCHQYDVWLLSDEIWGDLAMRDNIYHSALSLPEKLQQKLIVATAASKTFG
CHHHHHHHHHHHHHCCEEEECHHHHCCHHHHHHHHHHHHCCHHHHHHHEEHEEECCCCCC
LSSVRISNFMIPNQELKARLVRRLDAHGMDVYNSLAMCAATAAYQTSAPWLNELKTYLQE
CCEEEHHHEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
NINTLSRFIETELPELSFTPPEAGYLAWVDCRALGLTDKELELKLVDAGIVPSMGIAFGS
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCCCEEECC
EGSGFIRLNLGCPREVLIQAMQRISVALNN
CCCCEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]