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The map label for this gene is htpX

Identifier: 209694853

GI number: 209694853

Start: 1433272

End: 1434147

Strand: Direct

Name: htpX

Synonym: VSAL_I1322

Alternate gene names: 209694853

Gene position: 1433272-1434147 (Clockwise)

Preceding gene: 209694851

Following gene: 209694854

Centisome position: 43.1

GC content: 41.21

Gene sequence:

>876_bases
ATGAAGCGTATTGCGCTGTTTTTAGCAACAAACTTAGCGGTAATGATCGTATTCAGTATTGTATTGAATATTGTTTATGC
AGTCACGGGGATTCAGCAAGGTAGCCTATCTGGCTTACTGGTTATGGCCGTATTATTTGGTTTTGGTGGTTCATTAGTTT
CTTTATTAATGTCCAAAAAAATGGCATTACGTTCAGTGGGTGGTGAAGTTATTGAACAACCACGTAATGAAACTGAACAT
TGGTTAATGGAAACCGTTTCTCGCCAAGCGCAACAAGTGGGCATTGGTATGCCGACTGTAGCGATTTACGATTCACCAGA
TATGAATGCGTTTGCAACGGGTGCAAAACGTGATGACTCTCTAGTCGCTGTATCTACTGGTTTATTACATAACATGACTC
GTGATGAGGCAGAGGCTGTTTTAGCGCATGAAGTGAGCCATATTGCTAACGGTGATATGATTACGATGACATTAATGCAA
GGTGTCGTGAATACCTTCGTTATCTTCTTATCTCGTATGATCGCCAATGCAGTGAGTGGGTTTACTTCTAATGATGAAGA
AGGTGAGGGCGAAGGCGGTAGCTTTATGACTTACTTTATTGTATCAACGGTATTAGAAATTGCGTTTGGTTTCTTAGCCA
GTTTCTTAACGATGTGGTTCAGCCGTCATCGTGAGTTTTATGCGGATGCAGGTGCTGCTAATTTAGTCGGTAAAGATAAA
ATGATAGCGGCTCTTGAGCGCCTACGAATGGGACAAGAATCTCAACTTGAAGGCTCTATGATGGCATTTGGTATTAATGG
TAAAAAGTCACTGACTGAGCTATTAATGAGCCATCCACCACTAGAAAAACGTATTAACGCACTGCGTCAGTTATAA

Upstream 100 bases:

>100_bases
CTTATGCATATACCTATTAAACGTGCTAGATGCGTTTGGTGTCTGCTCAAAAAAACAAAATCAATGAGTAGAATTAAATT
ATTAATCGGAGAAAGAATAA

Downstream 100 bases:

>100_bases
TACTGTTAACGTTTATGTGATTGTGATGAAACCCGAGATTATTCTCGGGTTTTTTATATCCAGAAACGACATAAATCTTT
TACCTATCTACATTACGAGT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKKMALRSVGGEVIEQPRNETEH
WLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQ
GVVNTFVIFLSRMIANAVSGFTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDK
MIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL

Sequences:

>Translated_291_residues
MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKKMALRSVGGEVIEQPRNETEH
WLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQ
GVVNTFVIFLSRMIANAVSGFTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDK
MIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL
>Mature_291_residues
MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKKMALRSVGGEVIEQPRNETEH
WLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQ
GVVNTFVIFLSRMIANAVSGFTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDK
MIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=291, Percent_Identity=69.0721649484536, Blast_Score=403, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ALISL (B6EKC3)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262781.1
- ProteinModelPortal:   B6EKC3
- GeneID:   6987000
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1322
- HOGENOM:   HBG739460
- OMA:   GKQKMIA
- ProtClustDB:   PRK05457
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.- [C]

Molecular weight: Translated: 31672; Mature: 31672

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0x1fe113e0)-; HASH(0x1d41887c)-; HASH(0x1dbd91a8)-; HASH(0x1fbb638c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
MALRSVGGEVIEQPRNETEHWLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDS
HHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCC
LVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQGVVNTFVIFLSRMIANAVSG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
MIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL
HHHHHHHHHCCCCHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCH
>Mature Secondary Structure
MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
MALRSVGGEVIEQPRNETEHWLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDS
HHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCC
LVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQGVVNTFVIFLSRMIANAVSG
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHH
MIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL
HHHHHHHHHCCCCHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA