Click here to switch to the map view.

The map label for this gene is pth

Identifier: 209694367

GI number: 209694367

Start: 871768

End: 872358

Strand: Reverse

Name: pth

Synonym: VSAL_I0785

Alternate gene names: 209694367

Gene position: 872358-871768 (Counterclockwise)

Preceding gene: 209694368

Following gene: 209694366

Centisome position: 26.24

GC content: 40.78

Gene sequence:

>591_bases
TTGAGTAATCAGATCAAACTTCTTGTTGGACTAGCAAACCCCGGCCTTGAGTACAAAAGAACTCGCCATAATGCTGGGGC
ATGGGTAGTTGAAGAACTCGCTCGCATTCATAACATTCCAATGCGTGAAGAAGCTAAGTTTTTTGGATTAACAGGTCGAA
TTCAAACCAATGGTCAGGATCTTCGATTACTAATCCCTACAACATTTATGAACTTATCAGGAAAAGCCATTGCTTCGATT
GCTAAGTTTTACCAAATAAAACCAGAAGAGATCCTCGTCGCTCATGATGAATTAGATCTTCCTCCTGGTGTTGCTAAATT
TAAAAAAGGTGGCGGGCATGGTGGCCATAATGGTCTTCGTGACACCATTAGTAAATTAGCGAATACGAAAGAGTTTTATC
GCCTTCGTATTGGCATTGGCCATCCTGGCCATAAAGACAAAGTTGCCGGTTTTGTATTAGGGAAAGCGCCGACTAAAGAG
CAAGAGTTGATCGATGCAGCAGTAGATGAATCTACTCGTTGCTTAGATATCTTACTTAAAGACGGACTAAGTAAAGCACA
AAATCGTTTACACACATTCAAAGCTGAATAA

Upstream 100 bases:

>100_bases
CCTTTTTAATGGTACATACTAATATCATTAATTGTCTTTAGCTCTCAGCGCTAAACAAGTTCATTAATCATATTAGTATC
CAAGATAGAGAGATAATTCT

Downstream 100 bases:

>100_bases
CAAAGATAAGGTTTACATCATGGGTTTTAAATGCGGAATCGTTGGTCTTCCAAACGTTGGTAAATCAACACTGTTTAACG
CACTAACTAAAGCTGGAATC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSNQIKLLVGLANPGLEYKRTRHNAGAWVVEELARIHNIPMREEAKFFGLTGRIQTNGQDLRLLIPTTFMNLSGKAIASI
AKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLRDTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKE
QELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE

Sequences:

>Translated_196_residues
MSNQIKLLVGLANPGLEYKRTRHNAGAWVVEELARIHNIPMREEAKFFGLTGRIQTNGQDLRLLIPTTFMNLSGKAIASI
AKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLRDTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKE
QELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE
>Mature_195_residues
SNQIKLLVGLANPGLEYKRTRHNAGAWVVEELARIHNIPMREEAKFFGLTGRIQTNGQDLRLLIPTTFMNLSGKAIASIA
KFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLRDTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQ
ELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=171, Percent_Identity=38.0116959064327, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=69.2708333333333, Blast_Score=260, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ALISL (B6EHH0)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262295.1
- GeneID:   6988441
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0785
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21640; Mature: 21509

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQIKLLVGLANPGLEYKRTRHNAGAWVVEELARIHNIPMREEAKFFGLTGRIQTNGQD
CCCCEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECCEEEEECCCE
LRLLIPTTFMNLSGKAIASIAKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLR
EEEEECCHHCCCCCHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHCCCCCCCCCCCHH
DTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQELIDAAVDESTRCLDILLK
HHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHH
DGLSKAQNRLHTFKAE
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNQIKLLVGLANPGLEYKRTRHNAGAWVVEELARIHNIPMREEAKFFGLTGRIQTNGQD
CCCEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEECCEEEEECCCE
LRLLIPTTFMNLSGKAIASIAKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLR
EEEEECCHHCCCCCHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHCCCCCCCCCCCHH
DTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQELIDAAVDESTRCLDILLK
HHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHH
DGLSKAQNRLHTFKAE
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA