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The map label for this gene is xseA

Identifier: 209694325

GI number: 209694325

Start: 819907

End: 821241

Strand: Reverse

Name: xseA

Synonym: VSAL_I0736

Alternate gene names: 209694325

Gene position: 821241-819907 (Counterclockwise)

Preceding gene: 209694329

Following gene: 209694303

Centisome position: 24.7

GC content: 40.6

Gene sequence:

>1335_bases
ATGTCTCTCGATTCTAATCCCCGCATCTTTACAGTCTCCCGATTGAATTCTGAAGTTCGTTTATTATTAGAAAATGAAAT
GGGAATTGTTTGGCTTGTTGGTGAAGTGTCTAACCTTACAATGCCCGTTTCTGGCCATTGGTATCTCACTCTTAAAGACA
GCCAAGCTCAAGTCAAATGTGCCATGTTTAAAGGCAATAATCGTCGCGTAACGTTTAAACCTCAGAATGGTAAGCAAGTA
CTTGTTAAAGCTCGTCTCTCTTTATATGAGCCTCGTGGTGACTATCAGTTAATCATTGAAAGCATGCAAGCTGAAGGGGA
TGGTCGTCTTCAACAAGAATTCGATCACTTAAAAATGTCATTAGCCGCTGAAGGCTTATTCGCTCAGACCGCTAAAAAGG
CCTTACCAGAGCAACCGAAATGTGTCGGTATTATTACGTCTAAAACAGGCGCGGCTCTTTTTGATATTTTAAACGTATTA
AAACGACGAGATCCAAATCTTCCTGTCATCATTTATCCAACCTTAGTTCAAGGCACAAATGCCGCCATTCAAATAGCGCA
AGCCATTGGACGAGCAAATAGCCGTAATGAATGTGATATTTTGATCGTTGGCCGTGGAGGCGGTTCATTAGAGGATCTTT
GGTGCTTTAATGAAGAAATTGTGGCAAGAACCATTGCTGCCAGTCAGATACCAATCGTCAGTGCTGTAGGTCATGAAATT
GATGTCACTATCGCTGATTTTGTTGCCGATGTACGTGCCCCAACACCTTCTGCTGCGGCAGAACTAGTGAGTCGAGATCT
CTCTTCTCAATTGCAGATAGTCTCGCATCAAAAACGTCGTTTACGCAGTGCTATTGAACGTTATTTATCCCAACAACAAA
AACGACTTTCGACATATCAATTTAGAATTGAAAAACAACATCCTCAACTTCAATTAAATACACAAAGCCAACGTTTAGAC
GATCTTAATCAACGCTTAGAAAATCATATTCAACAGCGACTAGAGCGTAATCAGCATAAAATAGAAAACCTTTCTTTACG
TCTTAGTAATTTATCTCCCGCAAGAAAAGTACACCAAGATAAGCAACGTATAGAGACATTAAAGCGTCGTCTTTTAGATT
CAATGGACAGAAACTTACTGATGCAACGTCATCAGCTTGCTTTAGCTGCTGAAAAACTGGATACCGTAAGCCCTCTTGCA
ACATTAAAGCGAGGCTATTCAATTACACGTAATGCATCAGGCAGTCTCATAACATCAACTCAGCAGGTTCATACTGGTGA
TACCATTACGACCCGCTTTGTTGATGGTGAAGTACAATCAACAGTCGATAAGTAA

Upstream 100 bases:

>100_bases
AAACGCTTGGCTAGACATTTATTTATTTTTAATTTGCAATTACCCCCTTGATATGTATTATATTGCCGCTAATTCCTATA
TTCATGTCTAAGGCATTCTC

Downstream 100 bases:

>100_bases
CTTACAGCTTATCGCTTAATTGTACTAACTCAGTCTTTACTCGTGATTTTGACTTCAGCTCATTACACTCATGGCAGAAA
TAATTTGCCGCACCACAGGC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSLDSNPRIFTVSRLNSEVRLLLENEMGIVWLVGEVSNLTMPVSGHWYLTLKDSQAQVKCAMFKGNNRRVTFKPQNGKQV
LVKARLSLYEPRGDYQLIIESMQAEGDGRLQQEFDHLKMSLAAEGLFAQTAKKALPEQPKCVGIITSKTGAALFDILNVL
KRRDPNLPVIIYPTLVQGTNAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASQIPIVSAVGHEI
DVTIADFVADVRAPTPSAAAELVSRDLSSQLQIVSHQKRRLRSAIERYLSQQQKRLSTYQFRIEKQHPQLQLNTQSQRLD
DLNQRLENHIQQRLERNQHKIENLSLRLSNLSPARKVHQDKQRIETLKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLA
TLKRGYSITRNASGSLITSTQQVHTGDTITTRFVDGEVQSTVDK

Sequences:

>Translated_444_residues
MSLDSNPRIFTVSRLNSEVRLLLENEMGIVWLVGEVSNLTMPVSGHWYLTLKDSQAQVKCAMFKGNNRRVTFKPQNGKQV
LVKARLSLYEPRGDYQLIIESMQAEGDGRLQQEFDHLKMSLAAEGLFAQTAKKALPEQPKCVGIITSKTGAALFDILNVL
KRRDPNLPVIIYPTLVQGTNAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASQIPIVSAVGHEI
DVTIADFVADVRAPTPSAAAELVSRDLSSQLQIVSHQKRRLRSAIERYLSQQQKRLSTYQFRIEKQHPQLQLNTQSQRLD
DLNQRLENHIQQRLERNQHKIENLSLRLSNLSPARKVHQDKQRIETLKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLA
TLKRGYSITRNASGSLITSTQQVHTGDTITTRFVDGEVQSTVDK
>Mature_443_residues
SLDSNPRIFTVSRLNSEVRLLLENEMGIVWLVGEVSNLTMPVSGHWYLTLKDSQAQVKCAMFKGNNRRVTFKPQNGKQVL
VKARLSLYEPRGDYQLIIESMQAEGDGRLQQEFDHLKMSLAAEGLFAQTAKKALPEQPKCVGIITSKTGAALFDILNVLK
RRDPNLPVIIYPTLVQGTNAAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASQIPIVSAVGHEID
VTIADFVADVRAPTPSAAAELVSRDLSSQLQIVSHQKRRLRSAIERYLSQQQKRLSTYQFRIEKQHPQLQLNTQSQRLDD
LNQRLENHIQQRLERNQHKIENLSLRLSNLSPARKVHQDKQRIETLKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLAT
LKRGYSITRNASGSLITSTQQVHTGDTITTRFVDGEVQSTVDK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=55.8352402745995, Blast_Score=496, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_ALISL (B6EGZ4)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262253.1
- GeneID:   6986628
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0736
- HOGENOM:   HBG634411
- OMA:   EQRASIG
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49935; Mature: 49804

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDSNPRIFTVSRLNSEVRLLLENEMGIVWLVGEVSNLTMPVSGHWYLTLKDSQAQVKC
CCCCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCEEEEECCEEEEEEECCCCEEEE
AMFKGNNRRVTFKPQNGKQVLVKARLSLYEPRGDYQLIIESMQAEGDGRLQQEFDHLKMS
EEEECCCCEEEECCCCCCEEHEEEHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LAAEGLFAQTAKKALPEQPKCVGIITSKTGAALFDILNVLKRRDPNLPVIIYPTLVQGTN
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECEECCCC
AAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASQIPIVSAVGHEI
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHCCCEE
DVTIADFVADVRAPTPSAAAELVSRDLSSQLQIVSHQKRRLRSAIERYLSQQQKRLSTYQ
EEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRIEKQHPQLQLNTQSQRLDDLNQRLENHIQQRLERNQHKIENLSLRLSNLSPARKVHQD
EEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
KQRIETLKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLATLKRGYSITRNASGSLITST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECC
QQVHTGDTITTRFVDGEVQSTVDK
CCEECCCCEEEEEECCHHHHHCCC
>Mature Secondary Structure 
SLDSNPRIFTVSRLNSEVRLLLENEMGIVWLVGEVSNLTMPVSGHWYLTLKDSQAQVKC
CCCCCCCEEEEEECCCEEEEEEECCCCEEEEEECCCCEEEEECCEEEEEEECCCCEEEE
AMFKGNNRRVTFKPQNGKQVLVKARLSLYEPRGDYQLIIESMQAEGDGRLQQEFDHLKMS
EEEECCCCEEEECCCCCCEEHEEEHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
LAAEGLFAQTAKKALPEQPKCVGIITSKTGAALFDILNVLKRRDPNLPVIIYPTLVQGTN
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECEECCCC
AAIQIAQAIGRANSRNECDILIVGRGGGSLEDLWCFNEEIVARTIAASQIPIVSAVGHEI
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHCCCEE
DVTIADFVADVRAPTPSAAAELVSRDLSSQLQIVSHQKRRLRSAIERYLSQQQKRLSTYQ
EEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FRIEKQHPQLQLNTQSQRLDDLNQRLENHIQQRLERNQHKIENLSLRLSNLSPARKVHQD
EEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHH
KQRIETLKRRLLDSMDRNLLMQRHQLALAAEKLDTVSPLATLKRGYSITRNASGSLITST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECC
QQVHTGDTITTRFVDGEVQSTVDK
CCEECCCCEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA