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The map label for this gene is hisS [H]

Identifier: 209694319

GI number: 209694319

Start: 813694

End: 814968

Strand: Direct

Name: hisS [H]

Synonym: VSAL_I0730

Alternate gene names: 209694319

Gene position: 813694-814968 (Clockwise)

Preceding gene: 209694318

Following gene: 209694320

Centisome position: 24.47

GC content: 42.2

Gene sequence:

>1275_bases
GTGAACGTGGCTAAAGCAATCCAAGCAATTCGAGGCATGAATGACTGCCTTCCAACACAGTCGCCATTGTGGCACAAAGT
AGAAGACAGCGTAAAACGCGTTATTAGTGCGTATGGCTATAGCGAAATTCGCATGCCGATTGTTGAACAGACGCATCTAT
TTAAGCGTGCTATCGGTGAAGTTACAGACGTTGTTGAAAAAGAAATGTATACGTTTGACGACCGTAATGGTGATAGCTTA
GCGCTTCGTCCAGAAGGTACTGCAGGTTGTGTACGTGCAGGGATTGAGAATGGTTTGTTGTACAACCAAGAACAACGTTT
ATGGTACATGGGACCAATGTTCCGTCATGAACGCCCTCAAAAAGGTCGTTACCGTCAATTCCACCAAGTAGGTGTTGAAG
TTTTCGGACTGAACGGTCCTGACGTTGATGCTGAACTTATCATGATGACAGCACGCTTGTGGCGTGAGCTAGGTATTGAT
AAGCACGTTCATTTAGAGCTTAACTCAATTGGTTCATTGGAAGCTCGTGCTAACTATCGTGTGGTATTAATTGAATTCCT
AGAACAACATTTAGATATCTTGGATGAAGATTGTAAGCGTCGTATGTACACTAACCCAATGCGTGTTCTTGATACTAAAA
ACCCAGCAGTACAAGCTATTTTAGGTGATGCGCCTAAGCTGTCTGAGTATTTAGATGATGATTCAAAAGCACATTTTTCT
GGATTATGTGAACTACTTGACGCTGCTGGCATCCAATATCAAGTTAATGAACGCTTAGTTCGTGGTTTAGATTATTATAA
CCGTACTGTTTTTGAGTGGGTAACTGAAAGTTTAGGCGCTCAAGGTACGGTATGTGCTGGTGGTCGTTACGATGGATTAG
TTGAGCAATTGGGTGGAAAAGAGACTTCAGCAGTTGGCTTTGCTATGGGACTTGAACGTTTAGTTCTTTTAATGGAAACA
TTAGAATTAACAGACGTACGCCGCTCAGTTGATATTTATATGGTGACTTCTGGAGCAGACACATTAATGGCTGGTATGAA
ACTGGCTGAACGACTGCGTGAACAGGTTCCTGGATTACGAGTAATGTGTCACTTCGGTGGTGGTAATTTTAAAAAGCAAT
TTAAACGTGCAGACAATGCGGGTGCAGCGGTAGCTCTTATTTTAGGTGAGAGTGAAGTTGCAGAGCTAACTGTAAACGTA
AAAGATTTACGTACTGGTGAGCAAGAGACATTCGCTCAAGCAGACGTATTCGCAAAATTAGCAGAATTGATTTAA

Upstream 100 bases:

>100_bases
AGGATCCGTGCAAAAGCAGCGATGTTATCAAAAGAAAATCAAATTGATATTAATCAGATCGACTGATTAATATCCAGATA
TAAATAAAACCCATTGGGAA

Downstream 100 bases:

>100_bases
GAGGATAGGACGTGGAAGCCTACGAAACTGAAGAACAACAAGTTGAAGCCATTAAAAGTTGGTGGAAAGAAAATGGCAAG
GCTGTCGTAATTGGTGGTGT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNVAKAIQAIRGMNDCLPTQSPLWHKVEDSVKRVISAYGYSEIRMPIVEQTHLFKRAIGEVTDVVEKEMYTFDDRNGDSL
ALRPEGTAGCVRAGIENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFHQVGVEVFGLNGPDVDAELIMMTARLWRELGID
KHVHLELNSIGSLEARANYRVVLIEFLEQHLDILDEDCKRRMYTNPMRVLDTKNPAVQAILGDAPKLSEYLDDDSKAHFS
GLCELLDAAGIQYQVNERLVRGLDYYNRTVFEWVTESLGAQGTVCAGGRYDGLVEQLGGKETSAVGFAMGLERLVLLMET
LELTDVRRSVDIYMVTSGADTLMAGMKLAERLREQVPGLRVMCHFGGGNFKKQFKRADNAGAAVALILGESEVAELTVNV
KDLRTGEQETFAQADVFAKLAELI

Sequences:

>Translated_424_residues
MNVAKAIQAIRGMNDCLPTQSPLWHKVEDSVKRVISAYGYSEIRMPIVEQTHLFKRAIGEVTDVVEKEMYTFDDRNGDSL
ALRPEGTAGCVRAGIENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFHQVGVEVFGLNGPDVDAELIMMTARLWRELGID
KHVHLELNSIGSLEARANYRVVLIEFLEQHLDILDEDCKRRMYTNPMRVLDTKNPAVQAILGDAPKLSEYLDDDSKAHFS
GLCELLDAAGIQYQVNERLVRGLDYYNRTVFEWVTESLGAQGTVCAGGRYDGLVEQLGGKETSAVGFAMGLERLVLLMET
LELTDVRRSVDIYMVTSGADTLMAGMKLAERLREQVPGLRVMCHFGGGNFKKQFKRADNAGAAVALILGESEVAELTVNV
KDLRTGEQETFAQADVFAKLAELI
>Mature_424_residues
MNVAKAIQAIRGMNDCLPTQSPLWHKVEDSVKRVISAYGYSEIRMPIVEQTHLFKRAIGEVTDVVEKEMYTFDDRNGDSL
ALRPEGTAGCVRAGIENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFHQVGVEVFGLNGPDVDAELIMMTARLWRELGID
KHVHLELNSIGSLEARANYRVVLIEFLEQHLDILDEDCKRRMYTNPMRVLDTKNPAVQAILGDAPKLSEYLDDDSKAHFS
GLCELLDAAGIQYQVNERLVRGLDYYNRTVFEWVTESLGAQGTVCAGGRYDGLVEQLGGKETSAVGFAMGLERLVLLMET
LELTDVRRSVDIYMVTSGADTLMAGMKLAERLREQVPGLRVMCHFGGGNFKKQFKRADNAGAAVALILGESEVAELTVNV
KDLRTGEQETFAQADVFAKLAELI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=423, Percent_Identity=73.0496453900709, Blast_Score=646, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71993686, Length=460, Percent_Identity=24.1304347826087, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71993693, Length=460, Percent_Identity=24.1304347826087, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47573; Mature: 47573

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVAKAIQAIRGMNDCLPTQSPLWHKVEDSVKRVISAYGYSEIRMPIVEQTHLFKRAIGE
CCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
VTDVVEKEMYTFDDRNGDSLALRPEGTAGCVRAGIENGLLYNQEQRLWYMGPMFRHERPQ
HHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCEECCCCCEEEECCHHHCCCCC
KGRYRQFHQVGVEVFGLNGPDVDAELIMMTARLWRELGIDKHVHLELNSIGSLEARANYR
CCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCH
VVLIEFLEQHLDILDEDCKRRMYTNPMRVLDTKNPAVQAILGDAPKLSEYLDDDSKAHFS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHCCCHHHHHHCCCCCHHHHH
GLCELLDAAGIQYQVNERLVRGLDYYNRTVFEWVTESLGAQGTVCAGGRYDGLVEQLGGK
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCC
ETSAVGFAMGLERLVLLMETLELTDVRRSVDIYMVTSGADTLMAGMKLAERLREQVPGLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHCCCEE
VMCHFGGGNFKKQFKRADNAGAAVALILGESEVAELTVNVKDLRTGEQETFAQADVFAKL
EEEEECCCCHHHHHHHCCCCCCEEEEEECCCCHHHEEEEHHHHCCCCHHHHHHHHHHHHH
AELI
HHHC
>Mature Secondary Structure
MNVAKAIQAIRGMNDCLPTQSPLWHKVEDSVKRVISAYGYSEIRMPIVEQTHLFKRAIGE
CCHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
VTDVVEKEMYTFDDRNGDSLALRPEGTAGCVRAGIENGLLYNQEQRLWYMGPMFRHERPQ
HHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHCCCEECCCCCEEEECCHHHCCCCC
KGRYRQFHQVGVEVFGLNGPDVDAELIMMTARLWRELGIDKHVHLELNSIGSLEARANYR
CCHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCH
VVLIEFLEQHLDILDEDCKRRMYTNPMRVLDTKNPAVQAILGDAPKLSEYLDDDSKAHFS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEECCCHHHHHHHCCCHHHHHHCCCCCHHHHH
GLCELLDAAGIQYQVNERLVRGLDYYNRTVFEWVTESLGAQGTVCAGGRYDGLVEQLGGK
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCC
ETSAVGFAMGLERLVLLMETLELTDVRRSVDIYMVTSGADTLMAGMKLAERLREQVPGLR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHCCCEE
VMCHFGGGNFKKQFKRADNAGAAVALILGESEVAELTVNVKDLRTGEQETFAQADVFAKL
EEEEECCCCHHHHHHHCCCCCCEEEEEECCCCHHHEEEEHHHHCCCCHHHHHHHHHHHHH
AELI
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA