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The map label for this gene is sufS [H]

Identifier: 209694279

GI number: 209694279

Start: 775361

End: 776578

Strand: Reverse

Name: sufS [H]

Synonym: VSAL_I0690

Alternate gene names: 209694279

Gene position: 776578-775361 (Counterclockwise)

Preceding gene: 209694283

Following gene: 209694278

Centisome position: 23.35

GC content: 40.64

Gene sequence:

>1218_bases
ATGACCGCATTTACTATTGACGCTGTTCGTTCTCAATTTCCCGCTCTATCACAAAAAATTAACGGGCAACCTATCGCTTA
TTTTGACAGCGCTGCCACCACTCAAAAACCAAAAGTGGTATTAAATGCGATTCAAGATTATTACCAAAATGATAATGCTA
ACGTGCATCGTGGTAGTCACAGTCTAACCGCCTCCGCAACCTTAAAATTTGAACAAGCAAGAGCAACCGTTCAGCAGTTT
ATTAATGCGAAAAACGCTAAAGAAATAATTTGGACTCGCGGGGCAACAGAGGCTATCAATCTAATCGCGCAAACTTACGC
TCGTAGCACATTACAGCCAGGTAATGAGATCCTAATTAGTGAATTGGAACATCATGCTAATATTGTGCCTTGGCAAATTG
TGGCAGAGCAAACTGGCGCAAAGATTATAAAAATACCAATGAAACAAGATTGCACATTAGATATGTTAGCTTTTGAGTCA
TTGGTAACCCAGAACACAAAAATCATCGCTATCGCTCAAGTAACCAATGTAACAGGAACATTAAACCCGATTGATACCAT
AATAAAAGCAGCGCATAACGTGGGAGCTATTGTCGTTATTGACGGTGCTCAAGGTATTGTTCATCACGATATTGATGTCC
AAGCAATGGATGCGGATTTTTACGTTTTCTCTGGGCATAAACTGTTTGCGCCAGCAGGCATTGGGGCTCTCTATGGTAAA
CAGCATCTATTGGAGTCGATGCCAGTTTGGCATGGTGGCGGTAAAATGGTTGAAAAGGTTTCATTTGAAAAAACCACGTT
TGCAGAACTTCCGGGGAAATTTGAAGCGGGAACACCAAATGTAGCTGGTGCGATTGCCTTTGCTACTGCAATTAAGTGGA
TTAAACAATTCGCCCACGATGATCTAAATACTCATATTAACGAACTTCGTCATATGGCCATTGATGGAATTAAAGACATT
GAAGACTTACGTTTTATAGGGCTACAAGATAATGCGAGTTTATTTTCTTTTGTGATTGATGGTGTTCACCACCAAGATAT
TGCGACTTTATTAGATCAACAAGGCATTGCTGTACGCTCAGGTAACCATTGTGCGCACCCTATGTTAGACGCATTAGGAT
TAACGGGAACTGTACGCGTTTCATTTGCCTTGTATAATACTAAGCAAGATGTTCAACGTTTTATCGACGCGCTAAATAAA
GCCGCTGATATGCTATAA

Upstream 100 bases:

>100_bases
GCACCGTTTAATACGGTGCTTTTTTTTGTCTGTAATTTTGACTTACGGCCAAGAAATCCGCATCATTCCCCCAGTTTGCT
AACCACTAAAGAAAATCACT

Downstream 100 bases:

>100_bases
GCCCAAGTTTAAGGTATTTTATTTATGTCTACATTCCCTTCATCACCTTTTGGCTTTGACGTCACTCACACCACGGTATT
GGATTTCATGAGTGAAGCGA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTAFTIDAVRSQFPALSQKINGQPIAYFDSAATTQKPKVVLNAIQDYYQNDNANVHRGSHSLTASATLKFEQARATVQQF
INAKNAKEIIWTRGATEAINLIAQTYARSTLQPGNEILISELEHHANIVPWQIVAEQTGAKIIKIPMKQDCTLDMLAFES
LVTQNTKIIAIAQVTNVTGTLNPIDTIIKAAHNVGAIVVIDGAQGIVHHDIDVQAMDADFYVFSGHKLFAPAGIGALYGK
QHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAIKWIKQFAHDDLNTHINELRHMAIDGIKDI
EDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNK
AADML

Sequences:

>Translated_405_residues
MTAFTIDAVRSQFPALSQKINGQPIAYFDSAATTQKPKVVLNAIQDYYQNDNANVHRGSHSLTASATLKFEQARATVQQF
INAKNAKEIIWTRGATEAINLIAQTYARSTLQPGNEILISELEHHANIVPWQIVAEQTGAKIIKIPMKQDCTLDMLAFES
LVTQNTKIIAIAQVTNVTGTLNPIDTIIKAAHNVGAIVVIDGAQGIVHHDIDVQAMDADFYVFSGHKLFAPAGIGALYGK
QHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAIKWIKQFAHDDLNTHINELRHMAIDGIKDI
EDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNK
AADML
>Mature_404_residues
TAFTIDAVRSQFPALSQKINGQPIAYFDSAATTQKPKVVLNAIQDYYQNDNANVHRGSHSLTASATLKFEQARATVQQFI
NAKNAKEIIWTRGATEAINLIAQTYARSTLQPGNEILISELEHHANIVPWQIVAEQTGAKIIKIPMKQDCTLDMLAFESL
VTQNTKIIAIAQVTNVTGTLNPIDTIIKAAHNVGAIVVIDGAQGIVHHDIDVQAMDADFYVFSGHKLFAPAGIGALYGKQ
HLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAIKWIKQFAHDDLNTHINELRHMAIDGIKDIE
DLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNKA
ADML

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=228, Percent_Identity=27.1929824561404, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=46.4197530864198, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=43.1761786600496, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=24.4949494949495, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI25143064, Length=396, Percent_Identity=26.5151515151515, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=414, Percent_Identity=25.6038647342995, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319831, Length=395, Percent_Identity=25.0632911392405, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20129463, Length=245, Percent_Identity=30.2040816326531, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44227; Mature: 44096

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFTIDAVRSQFPALSQKINGQPIAYFDSAATTQKPKVVLNAIQDYYQNDNANVHRGSH
CCEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEECCCC
SLTASATLKFEQARATVQQFINAKNAKEIIWTRGATEAINLIAQTYARSTLQPGNEILIS
CEEEEEEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHH
ELEHHANIVPWQIVAEQTGAKIIKIPMKQDCTLDMLAFESLVTQNTKIIAIAQVTNVTGT
HHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCC
LNPIDTIIKAAHNVGAIVVIDGAQGIVHHDIDVQAMDADFYVFSGHKLFAPAGIGALYGK
CCHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEECCCEEEEECCEEECCCCCHHHHHH
QHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAIKWIKQFAHD
HHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
DLNTHINELRHMAIDGIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRS
HHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEEC
GNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNKAADML
CCCCCHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAFTIDAVRSQFPALSQKINGQPIAYFDSAATTQKPKVVLNAIQDYYQNDNANVHRGSH
CEEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEECCCC
SLTASATLKFEQARATVQQFINAKNAKEIIWTRGATEAINLIAQTYARSTLQPGNEILIS
CEEEEEEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHH
ELEHHANIVPWQIVAEQTGAKIIKIPMKQDCTLDMLAFESLVTQNTKIIAIAQVTNVTGT
HHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCC
LNPIDTIIKAAHNVGAIVVIDGAQGIVHHDIDVQAMDADFYVFSGHKLFAPAGIGALYGK
CCHHHHHHHHHHCCCEEEEEECCCCEEEECCCEEEECCCEEEEECCEEECCCCCHHHHHH
QHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAIKWIKQFAHD
HHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
DLNTHINELRHMAIDGIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRS
HHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCEEEC
GNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNKAADML
CCCCCHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]