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The map label for this gene is mltA [H]

Identifier: 209694276

GI number: 209694276

Start: 772764

End: 773864

Strand: Direct

Name: mltA [H]

Synonym: VSAL_I0687

Alternate gene names: 209694276

Gene position: 772764-773864 (Clockwise)

Preceding gene: 209694275

Following gene: 209694277

Centisome position: 23.24

GC content: 39.06

Gene sequence:

>1101_bases
GTGCTTCGTAAACTTCCTTTTGTTTGTATTCTTCTTGCTTTAGCCGGTTGTGCTGATCAACCGACTGATCGTGCTCAGCA
GTATTTGGATGGCAGTTTTAGCAGTAACTTAAATGAAGTCAGTGATATTGATTCAGATAAACCCTCTGATTTTAGTGCAT
TTAAAAATCAAAGCAAAGAAGTGGTAGAGCGTTCTGAATCCATGTCTTTACGTTATGAAGAGCTTTATACGAAACTTCAA
CAGTGGATTGATGAAAGTTCAAATCCTGCTAAATTATCAAATTACGGAATTCAATTTGCTCAAATGGGTGGTGGTGATAA
ACAAGGGAACGTGATGTTTACTGGTTATTTTTCACCAGTGATTGAAATGCGTCATAAGCCAACGGATAAATTTAAATACC
CTGTTTATGATAAACCAGCATGTGGTTCTAATTGTCCAACACGTGCTGAAATAAATGCAGGCGCTTTATCTGGGTTAGGT
TTAGAGCTTGGTTACTCAGATAATATGATTGACCCATTTATTATGGAAGTGCAAGGCAGTGGTTTTATTCATTTTGGTGA
CGATGACAAGCTAGAGTATTTTGCCTACGGTGGGAAGAATAACCATCCTTATGTGAGTATTGGTAAAGTACTTATTGAAC
GCGGTGAAGTTGAACGCAAAGACATGTCGTTAAAAGCGATTAAAGAATGGGTTGAAAGAAACGATGATGCGACCGTTCGT
GAATTGTTAGAAACTAACCCATCGTATGTTTTCTTTTCACCAAGGGACGCCAATCATGTATTAGGTACGGCGGGTATCCC
TTTAATTGCAGGGGCAGCTGTTGCAGCAGATCGTACTTTATTGCCTATGGGAACCCCTATACTTGCGGAAGTTCCACAAT
TGGATAAAGACGGTAAATGGACAGGTAAGCATGTACTTAAAGTTCTACTTGCATTAGATACCGGTGGCGCAGTAAAAGAA
AATCATTTAGACCAATATTATGGAATGGGGCCAGAAGCGGGTATTGCTGCAGGGCACTTTAAACATTTTGGTCGAGTATG
GAAATTAGGTTTAAAAGATTCTGAAACTGAAAATCCATGGGAAATGCCAAAAAAGAAATAG

Upstream 100 bases:

>100_bases
CAAAATTCTCCTTTTCTTACATTTATTCCATTCTAGGGAATTGCTCTCTTTCTATTTGTTTGTCATTCTTGCCGCACTAT
TTAATAAGTAAGGTCTTATT

Downstream 100 bases:

>100_bases
GGCTGAAATAAACCTGGATTTCTTAAAGCTTGATCTTCTAAAAAAGAGTGCGTATAAATCGTGCTCTTTTTTTGTTTTTG
AGTAAGGAAAACCCATGCGC

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MLRKLPFVCILLALAGCADQPTDRAQQYLDGSFSSNLNEVSDIDSDKPSDFSAFKNQSKEVVERSESMSLRYEELYTKLQ
QWIDESSNPAKLSNYGIQFAQMGGGDKQGNVMFTGYFSPVIEMRHKPTDKFKYPVYDKPACGSNCPTRAEINAGALSGLG
LELGYSDNMIDPFIMEVQGSGFIHFGDDDKLEYFAYGGKNNHPYVSIGKVLIERGEVERKDMSLKAIKEWVERNDDATVR
ELLETNPSYVFFSPRDANHVLGTAGIPLIAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGPEAGIAAGHFKHFGRVWKLGLKDSETENPWEMPKKK

Sequences:

>Translated_366_residues
MLRKLPFVCILLALAGCADQPTDRAQQYLDGSFSSNLNEVSDIDSDKPSDFSAFKNQSKEVVERSESMSLRYEELYTKLQ
QWIDESSNPAKLSNYGIQFAQMGGGDKQGNVMFTGYFSPVIEMRHKPTDKFKYPVYDKPACGSNCPTRAEINAGALSGLG
LELGYSDNMIDPFIMEVQGSGFIHFGDDDKLEYFAYGGKNNHPYVSIGKVLIERGEVERKDMSLKAIKEWVERNDDATVR
ELLETNPSYVFFSPRDANHVLGTAGIPLIAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGPEAGIAAGHFKHFGRVWKLGLKDSETENPWEMPKKK
>Mature_366_residues
MLRKLPFVCILLALAGCADQPTDRAQQYLDGSFSSNLNEVSDIDSDKPSDFSAFKNQSKEVVERSESMSLRYEELYTKLQ
QWIDESSNPAKLSNYGIQFAQMGGGDKQGNVMFTGYFSPVIEMRHKPTDKFKYPVYDKPACGSNCPTRAEINAGALSGLG
LELGYSDNMIDPFIMEVQGSGFIHFGDDDKLEYFAYGGKNNHPYVSIGKVLIERGEVERKDMSLKAIKEWVERNDDATVR
ELLETNPSYVFFSPRDANHVLGTAGIPLIAGAAVAADRTLLPMGTPILAEVPQLDKDGKWTGKHVLKVLLALDTGGAVKE
NHLDQYYGMGPEAGIAAGHFKHFGRVWKLGLKDSETENPWEMPKKK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=342, Percent_Identity=46.1988304093567, Blast_Score=325, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40576; Mature: 40576

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKLPFVCILLALAGCADQPTDRAQQYLDGSFSSNLNEVSDIDSDKPSDFSAFKNQSKE
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCHHHHHCCCCCCCHHHHHHHHHHH
VVERSESMSLRYEELYTKLQQWIDESSNPAKLSNYGIQFAQMGGGDKQGNVMFTGYFSPV
HHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCCCCCEEEEECHHHH
IEMRHKPTDKFKYPVYDKPACGSNCPTRAEINAGALSGLGLELGYSDNMIDPFIMEVQGS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEECCC
GFIHFGDDDKLEYFAYGGKNNHPYVSIGKVLIERGEVERKDMSLKAIKEWVERNDDATVR
EEEEECCCCCEEEEEECCCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
ELLETNPSYVFFSPRDANHVLGTAGIPLIAGAAVAADRTLLPMGTPILAEVPQLDKDGKW
HHHHCCCCEEEECCCCCCCEECCCCCHHHHHHHHHCCCEECCCCCHHHHHCCCCCCCCCC
TGKHVLKVLLALDTGGAVKENHLDQYYGMGPEAGIAAGHFKHFGRVWKLGLKDSETENPW
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
EMPKKK
CCCCCC
>Mature Secondary Structure
MLRKLPFVCILLALAGCADQPTDRAQQYLDGSFSSNLNEVSDIDSDKPSDFSAFKNQSKE
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHCCCHHHHHCCCCCCCHHHHHHHHHHH
VVERSESMSLRYEELYTKLQQWIDESSNPAKLSNYGIQFAQMGGGDKQGNVMFTGYFSPV
HHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHCCEEEEECCCCCCCCCEEEEECHHHH
IEMRHKPTDKFKYPVYDKPACGSNCPTRAEINAGALSGLGLELGYSDNMIDPFIMEVQGS
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEECCC
GFIHFGDDDKLEYFAYGGKNNHPYVSIGKVLIERGEVERKDMSLKAIKEWVERNDDATVR
EEEEECCCCCEEEEEECCCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
ELLETNPSYVFFSPRDANHVLGTAGIPLIAGAAVAADRTLLPMGTPILAEVPQLDKDGKW
HHHHCCCCEEEECCCCCCCEECCCCCHHHHHHHHHCCCEECCCCCHHHHHCCCCCCCCCC
TGKHVLKVLLALDTGGAVKENHLDQYYGMGPEAGIAAGHFKHFGRVWKLGLKDSETENPW
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
EMPKKK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]