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The map label for this gene is trpR

Identifier: 209694249

GI number: 209694249

Start: 732680

End: 733006

Strand: Direct

Name: trpR

Synonym: VSAL_I0659

Alternate gene names: 209694249

Gene position: 732680-733006 (Clockwise)

Preceding gene: 209694248

Following gene: 209694254

Centisome position: 22.03

GC content: 39.76

Gene sequence:

>327_bases
ATGTCTGGTTCAGCCAAATATTCAGATTGGTCGCAAGTTATGGCATTGATAGCAAATGCAGCAGAGCAAAATAAACATCA
ATCTTTATTAACGATGCTGATGACACCTGATGAGCGTGAAGCATTAATGGCTCGCGTTAACATATGTCATGAACTCTTGC
AGGGTGATTTAAGTCAAAGACAAATAAGTCAGCTACTTGGTGTCGGGGTTGCAACGATTACACGAGGTTCAAATGAATTA
AAAAGCCATACTGATGATGAAAAAGCATGGCTAATGGAAGTTCTTGAAGTGAGTGCTAAAAGCGATCAGGGTGCAAGAAA
GGAATAA

Upstream 100 bases:

>100_bases
TCTGTTAAAGAGCTTAATTTAGAGTATTAATTTTTTTAGATTAATTATAGAGTAGGGGACTTTAGAGTCCCCTTTCTTTT
ATCATTATATTGAGGATTGT

Downstream 100 bases:

>100_bases
GTGCGAGAATTAACGCTTGCTGATAAACAGAACTTCTAGTCAATAGATTGTTTGTTAGCAAGCCAATAGCGCCACCTTTT
TGCTTTATATTATCAGTATT

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSGSAKYSDWSQVMALIANAAEQNKHQSLLTMLMTPDEREALMARVNICHELLQGDLSQRQISQLLGVGVATITRGSNEL
KSHTDDEKAWLMEVLEVSAKSDQGARKE

Sequences:

>Translated_108_residues
MSGSAKYSDWSQVMALIANAAEQNKHQSLLTMLMTPDEREALMARVNICHELLQGDLSQRQISQLLGVGVATITRGSNEL
KSHTDDEKAWLMEVLEVSAKSDQGARKE
>Mature_107_residues
SGSAKYSDWSQVMALIANAAEQNKHQSLLTMLMTPDEREALMARVNICHELLQGDLSQRQISQLLGVGVATITRGSNELK
SHTDDEKAWLMEVLEVSAKSDQGARKE

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family

Homologues:

Organism=Escherichia coli, GI1790854, Length=90, Percent_Identity=47.7777777777778, Blast_Score=82, Evalue=7e-18,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): TRPR_ALISL (B6EGC9)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262177.1
- ProteinModelPortal:   B6EGC9
- GeneID:   6989247
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0659
- HOGENOM:   HBG677773
- OMA:   ELMRGEM
- ProtClustDB:   PRK01381
- GO:   GO:0005737
- HAMAP:   MF_00475
- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1270.10
- PIRSF:   PIRSF003196
- ProDom:   PD012582
- TIGRFAMs:   TIGR01321

Pfam domain/function: PF01371 Trp_repressor; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 11943; Mature: 11811

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSAKYSDWSQVMALIANAAEQNKHQSLLTMLMTPDEREALMARVNICHELLQGDLSQR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH
QISQLLGVGVATITRGSNELKSHTDDEKAWLMEVLEVSAKSDQGARKE
HHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SGSAKYSDWSQVMALIANAAEQNKHQSLLTMLMTPDEREALMARVNICHELLQGDLSQR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHH
QISQLLGVGVATITRGSNELKSHTDDEKAWLMEVLEVSAKSDQGARKE
HHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA