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The map label for this gene is ffh [H]

Identifier: 209694239

GI number: 209694239

Start: 721225

End: 722610

Strand: Direct

Name: ffh [H]

Synonym: VSAL_I0648

Alternate gene names: 209694239

Gene position: 721225-722610 (Clockwise)

Preceding gene: 209694236

Following gene: 209694240

Centisome position: 21.69

GC content: 40.69

Gene sequence:

>1386_bases
ATGTTTGATAATTTAACGGATAGACTATCCAAAACCCTGAAAAACATCAGTGGTAAAGGTCGATTAACAGAAGAAAACAT
TAAAGAAACGCTACGTGAAGTTCGTATGGCTTTGTTAGAAGCAGACGTTGCTTTACCTGTTGTTCGTGACTTTGTTAAGC
GAATAAAAGAAAACGCCGTAGGGGTTGAGGTATCAAAAAGCCTAACACCGGGTCAAGAATTCATTAAAATCGTTCAGTCT
GAGCTAGAAGCGATAATGGGAGACTCAAATGAGGCTCTAAATTTAGCGTGTCAGCCGCCTGCGGTTATTTTAATGGCAGG
TTTACAAGGTGCAGGTAAAACAACCAGTACTGGTAAATTAGCGAAGCTATTAAAAGAAAGAGATAAAAAGAAAGTTTTAG
TTGTGTCTGCCGATGTATACCGTCCTGCGGCAATTAAACAGCTAGAAATGTTAGCGTCAGAAGTTGATGTCGATTTCTTC
CCATCAAGTGCAGATCAAAAACCGATTGATATTGTTGATGGTGCAATTAGCCACGCTAAGTTAAAGTTTTTTGATGTTGT
TATCGTTGATACGGCTGGTCGTCTAGCTGTTGATACTGAAATGATGGAAGAAATTAAGCAGCTTCATGCACATGTAAATC
CAATTGAAACGTTATTTGTTGTCGATGCAATGACGGGGCAAGATGCCGCTAATACGGCAAAAGCGTTTGGTGATATTTTA
CCACTTACGGGTGTTATTCTAACCAAAGTAGACGGTGATGCTCGTGGTGGTGCTGCATTATCTGTTCGTCACATTACGGG
CAAGCCAATTAAATTCTTAGGTGTCGGTGAAAAAACGGATGCACTAGAACCTTTCCACCCAGAACGTATTGCTTCTCGTA
TTTTAGGTATGGGTGATGTTCTTTCTCTAATTGAAGATCTAGAGAAGAACGTAGATAAAGAAAAAGCAGAACGATTAGCG
AAAAAGTTCAAAGAGAAGAAAGGTTTTGATCTTGAAGATTTTCGTGAGCAGCTTGGTCAGATGACAAATATGGGTGGCAT
GATGGGGATGATGGATAAGCTTCCTGGTATGTCTCAGCTACCTGCTAATGTCAAAGATAAAGTGGACGACAAAATGTTCA
ATCAAATGGAAGCCATTATTAATTCCATGACAATGAAAGAACGCCAGCGTCCTGAACTAATTAAAGGCTCACGTAAAAAA
CGTATTGCAGCAGGTTCTGGTACTCAAGTACAAGATGTGAATCGCATGCTGAAACAGTTTACTCAAATGCAGAAAATGAT
GAAAAAAATGCAGAAAGGTGGCATGAAAGGCATGATGCGTAATATGCAAGGCATGATGGGCGGAATGGGCGGAATGGGCG
GTGGTATGGGTGGCTTTGGCCGCTAA

Upstream 100 bases:

>100_bases
GAGTGATTCGGTTAGGATAAAAAATTTTAATTATAACCAACAATATTTTGCCTACTATTAGGTTATAATTGATCAATGCT
CGCAGATTAGGCGCAAGAAT

Downstream 100 bases:

>100_bases
TATTCAATTGCACATTGTCAAAGTGTATTAATCAGATAACAAGGTGCGACAAGTGAATTTTTTAATAAATTTTACCTAGC
GCACCTTTTTCACCCCATTT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MFDNLTDRLSKTLKNISGKGRLTEENIKETLREVRMALLEADVALPVVRDFVKRIKENAVGVEVSKSLTPGQEFIKIVQS
ELEAIMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLEMLASEVDVDFF
PSSADQKPIDIVDGAISHAKLKFFDVVIVDTAGRLAVDTEMMEEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDIL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAERLA
KKFKEKKGFDLEDFREQLGQMTNMGGMMGMMDKLPGMSQLPANVKDKVDDKMFNQMEAIINSMTMKERQRPELIKGSRKK
RIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGGMGGFGR

Sequences:

>Translated_461_residues
MFDNLTDRLSKTLKNISGKGRLTEENIKETLREVRMALLEADVALPVVRDFVKRIKENAVGVEVSKSLTPGQEFIKIVQS
ELEAIMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLEMLASEVDVDFF
PSSADQKPIDIVDGAISHAKLKFFDVVIVDTAGRLAVDTEMMEEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDIL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAERLA
KKFKEKKGFDLEDFREQLGQMTNMGGMMGMMDKLPGMSQLPANVKDKVDDKMFNQMEAIINSMTMKERQRPELIKGSRKK
RIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGGMGGFGR
>Mature_461_residues
MFDNLTDRLSKTLKNISGKGRLTEENIKETLREVRMALLEADVALPVVRDFVKRIKENAVGVEVSKSLTPGQEFIKIVQS
ELEAIMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLEMLASEVDVDFF
PSSADQKPIDIVDGAISHAKLKFFDVVIVDTAGRLAVDTEMMEEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDIL
PLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAERLA
KKFKEKKGFDLEDFREQLGQMTNMGGMMGMMDKLPGMSQLPANVKDKVDDKMFNQMEAIINSMTMKERQRPELIKGSRKK
RIAAGSGTQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGGMGGFGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=31.3769751693002, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=33.6231884057971, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=38.8888888888889, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=25.9375, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI295424842, Length=320, Percent_Identity=25.9375, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788963, Length=446, Percent_Identity=76.2331838565022, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=35.0597609561753, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.8206278026906, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=33.1683168316832, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325345, Length=442, Percent_Identity=33.0316742081448, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=26.517571884984, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=30.2222222222222, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.6363636363636, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50509; Mature: 50509

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.4 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.4 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTDRLSKTLKNISGKGRLTEENIKETLREVRMALLEADVALPVVRDFVKRIKENAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVEVSKSLTPGQEFIKIVQSELEAIMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKL
CEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHEECCCCCCCCCCHHHH
AKLLKERDKKKVLVVSADVYRPAAIKQLEMLASEVDVDFFPSSADQKPIDIVDGAISHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFFDVVIVDTAGRLAVDTEMMEEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDIL
HEEEEEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHH
PLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPERIASRILGMGDV
HHHHHHEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLEKNVDKEKAERLAKKFKEKKGFDLEDFREQLGQMTNMGGMMGMMDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
PANVKDKVDDKMFNQMEAIINSMTMKERQRPELIKGSRKKRIAAGSGTQVQDVNRMLKQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHEEECCCCCHHHHHHHHHHHH
TQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGGMGGFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDNLTDRLSKTLKNISGKGRLTEENIKETLREVRMALLEADVALPVVRDFVKRIKENAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GVEVSKSLTPGQEFIKIVQSELEAIMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKL
CEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHEECCCCCCCCCCHHHH
AKLLKERDKKKVLVVSADVYRPAAIKQLEMLASEVDVDFFPSSADQKPIDIVDGAISHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFFDVVIVDTAGRLAVDTEMMEEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDIL
HEEEEEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHHHH
PLTGVILTKVDGDARGGAALSVRHITGKPIKFLGVGEKTDALEPFHPERIASRILGMGDV
HHHHHHEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLEKNVDKEKAERLAKKFKEKKGFDLEDFREQLGQMTNMGGMMGMMDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
PANVKDKVDDKMFNQMEAIINSMTMKERQRPELIKGSRKKRIAAGSGTQVQDVNRMLKQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHEEECCCCCHHHHHHHHHHHH
TQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGGMGGFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]