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The map label for this gene is lysC [H]

Identifier: 209694227

GI number: 209694227

Start: 706221

End: 707390

Strand: Direct

Name: lysC [H]

Synonym: VSAL_I0636

Alternate gene names: 209694227

Gene position: 706221-707390 (Clockwise)

Preceding gene: 209694226

Following gene: 209694228

Centisome position: 21.24

GC content: 37.26

Gene sequence:

>1170_bases
GTGGCATTAATCGTACAAAAGTATGGTGGAACATCAGTTGGGTCCGTTGAACGGATCCAACTTGTTTCTGACCGTATAAT
TTTAACGAAACAGCAAGGACACCAAGTGGTTGTTGCTGTTTCTGCTATGGCAGGAGAAACGAATCGTTTGCTAAATTTAG
CACATCAAATCAATGAGGTTCCAGAACCTCGTGAATTAGATATGTTACTTTCTGCAGGTGAACAAGTTTCTATTGCTCTT
TTAGCTATATCTTTGAATCAAAAAGGCATCAAAGCGATTTCTCTGACTGCAGATCAAGCAGGAATTAAAACCAATGATGT
ATTTAACGATGCAACTATCGAACATATTGAAACCAGTAAACTGACCGAATGGCTTGATAAGGGTTATGTTGTCATTGTTG
CTGGTTTTCAAGGTAGAGATAGTGTCGGAAATATTACAACACTCGGAAGAGGTGGGTCTGATACAACGGCTGTTGCTTTA
GCTGCCGCATTGAAAGCGGATGAATGTCAGATCTTTACTGATGTAGACGGTGTGTATTCTTCAGATCCCCGTTATGTATC
GAATACTCGTAAATTAAAAGAAGTTTCTTTTAGTGATATGCACGCATTAGCAAAGTCTGGTGCGAAAGTATTACAGGAAC
ATTCAGTATCTCATGCATGGAGATCTTCAGTATCATTAAGAGTTCTTTCTTCTTTTGATAATGGTGAAGGAACGCTTATT
TGTGAGAAGCCTAATGACTATTTTCCAGTTACTGGGTTAGCACTAAAGCAAGACTTATACCTTGCCGAATGCACTGACAT
AAATGAAGAGGATAGAATTCTTCTTGCTAAAGAGTATCGAGTGTTAACTAATACTGACGATTGTTTTCAAATTGTTGTGC
CAAAAGCAACTTTTTTACAATTGAAACTGGTATTTAATACAAAAATACGCAATATTAGTAGCTTATCAATTCTGACGTTA
GTCGGAGATAATGTTGAAGGGATGGCAGACTCTGCTTGCAATCAACTAATGGTTAATAGTGTTGATATCTATCAATGTTA
TACAGAACCAAAAAGTGTGTCGGTTATCGTTATTCAAGCTGATTTACAACAAGCGGCCGAAATTTTACATAAAACGTTTG
TTATTACAGAGCAATCACAAGATAATAACGTTCTGATCGCTGTTTCTTGA

Upstream 100 bases:

>100_bases
TGATATGGCTCAAGCGGGCGGTACCGATGCAAAAGCATTACCTGCAGCGTTAGCGACGGTTGAAGCTTGGTTAACTGAGC
GTCTTTCATAGGGCGTATCA

Downstream 100 bases:

>100_bases
GCAGAGACGTTTGTGAACATAAGCGATAACGGACAATACATACATTTATTATAATACTGAGATAACTCAAGGAGCATTCG
AATGCTAATTTTGACTCGCC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MALIVQKYGGTSVGSVERIQLVSDRIILTKQQGHQVVVAVSAMAGETNRLLNLAHQINEVPEPRELDMLLSAGEQVSIAL
LAISLNQKGIKAISLTADQAGIKTNDVFNDATIEHIETSKLTEWLDKGYVVIVAGFQGRDSVGNITTLGRGGSDTTAVAL
AAALKADECQIFTDVDGVYSSDPRYVSNTRKLKEVSFSDMHALAKSGAKVLQEHSVSHAWRSSVSLRVLSSFDNGEGTLI
CEKPNDYFPVTGLALKQDLYLAECTDINEEDRILLAKEYRVLTNTDDCFQIVVPKATFLQLKLVFNTKIRNISSLSILTL
VGDNVEGMADSACNQLMVNSVDIYQCYTEPKSVSVIVIQADLQQAAEILHKTFVITEQSQDNNVLIAVS

Sequences:

>Translated_389_residues
MALIVQKYGGTSVGSVERIQLVSDRIILTKQQGHQVVVAVSAMAGETNRLLNLAHQINEVPEPRELDMLLSAGEQVSIAL
LAISLNQKGIKAISLTADQAGIKTNDVFNDATIEHIETSKLTEWLDKGYVVIVAGFQGRDSVGNITTLGRGGSDTTAVAL
AAALKADECQIFTDVDGVYSSDPRYVSNTRKLKEVSFSDMHALAKSGAKVLQEHSVSHAWRSSVSLRVLSSFDNGEGTLI
CEKPNDYFPVTGLALKQDLYLAECTDINEEDRILLAKEYRVLTNTDDCFQIVVPKATFLQLKLVFNTKIRNISSLSILTL
VGDNVEGMADSACNQLMVNSVDIYQCYTEPKSVSVIVIQADLQQAAEILHKTFVITEQSQDNNVLIAVS
>Mature_388_residues
ALIVQKYGGTSVGSVERIQLVSDRIILTKQQGHQVVVAVSAMAGETNRLLNLAHQINEVPEPRELDMLLSAGEQVSIALL
AISLNQKGIKAISLTADQAGIKTNDVFNDATIEHIETSKLTEWLDKGYVVIVAGFQGRDSVGNITTLGRGGSDTTAVALA
AALKADECQIFTDVDGVYSSDPRYVSNTRKLKEVSFSDMHALAKSGAKVLQEHSVSHAWRSSVSLRVLSSFDNGEGTLIC
EKPNDYFPVTGLALKQDLYLAECTDINEEDRILLAKEYRVLTNTDDCFQIVVPKATFLQLKLVFNTKIRNISSLSILTLV
GDNVEGMADSACNQLMVNSVDIYQCYTEPKSVSVIVIQADLQQAAEILHKTFVITEQSQDNNVLIAVS

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=345, Percent_Identity=25.2173913043478, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790455, Length=337, Percent_Identity=30.5637982195846, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790376, Length=173, Percent_Identity=28.9017341040462, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=227, Percent_Identity=25.9911894273128, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42352; Mature: 42220

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSVGSVERIQLVSDRIILTKQQGHQVVVAVSAMAGETNRLLNLAHQINEV
CEEEEEECCCCCCCCHHEEEEEECEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCC
PEPRELDMLLSAGEQVSIALLAISLNQKGIKAISLTADQAGIKTNDVFNDATIEHIETSK
CCCHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LTEWLDKGYVVIVAGFQGRDSVGNITTLGRGGSDTTAVALAAALKADECQIFTDVDGVYS
HHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
SDPRYVSNTRKLKEVSFSDMHALAKSGAKVLQEHSVSHAWRSSVSLRVLSSFDNGEGTLI
CCCCCHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEE
CEKPNDYFPVTGLALKQDLYLAECTDINEEDRILLAKEYRVLTNTDDCFQIVVPKATFLQ
EECCCCCCCCCCEEEECCEEEEECCCCCCCCCEEEEECEEEECCCCCEEEEEECCCEEEE
LKLVFNTKIRNISSLSILTLVGDNVEGMADSACNQLMVNSVDIYQCYTEPKSVSVIVIQA
EEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEC
DLQQAAEILHKTFVITEQSQDNNVLIAVS
CHHHHHHHHHHEEEEEECCCCCCEEEEEC
>Mature Secondary Structure 
ALIVQKYGGTSVGSVERIQLVSDRIILTKQQGHQVVVAVSAMAGETNRLLNLAHQINEV
EEEEEECCCCCCCCHHEEEEEECEEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHCC
PEPRELDMLLSAGEQVSIALLAISLNQKGIKAISLTADQAGIKTNDVFNDATIEHIETSK
CCCHHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHH
LTEWLDKGYVVIVAGFQGRDSVGNITTLGRGGSDTTAVALAAALKADECQIFTDVDGVYS
HHHHHCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCC
SDPRYVSNTRKLKEVSFSDMHALAKSGAKVLQEHSVSHAWRSSVSLRVLSSFDNGEGTLI
CCCCCHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEE
CEKPNDYFPVTGLALKQDLYLAECTDINEEDRILLAKEYRVLTNTDDCFQIVVPKATFLQ
EECCCCCCCCCCEEEECCEEEEECCCCCCCCCEEEEECEEEECCCCCEEEEEECCCEEEE
LKLVFNTKIRNISSLSILTLVGDNVEGMADSACNQLMVNSVDIYQCYTEPKSVSVIVIQA
EEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEC
DLQQAAEILHKTFVITEQSQDNNVLIAVS
CHHHHHHHHHHEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]