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The map label for this gene is deoA

Identifier: 209694212

GI number: 209694212

Start: 682400

End: 683731

Strand: Direct

Name: deoA

Synonym: VSAL_I0620

Alternate gene names: 209694212

Gene position: 682400-683731 (Clockwise)

Preceding gene: 209694211

Following gene: 209694213

Centisome position: 20.52

GC content: 42.19

Gene sequence:

>1332_bases
ATGTATCTACCACAAGAGATTATTCGTAGAAAACGCGACAATAAAGTACTAACAACAGAAGAAATTAACTTTTTTATTCA
AGGTGTTGCAAAAAATACCGTGTCTGAAGGTCAAATTGCAGCATTTGCAATGGCGGTATATTTTAATGAAATGACGATGC
CTGAACGTATTGCATTAACGTGTGCAATGCGTGATTCAGGAATGGTAATTGATTGGAGCCATATGAACTTCGATGGCCCA
ATTGTTGATAAACATTCAACCGGTGGTGTTGGTGATGTAACCTCATTAATGCTTGGTCCTATGGTGGCGGCATGTGGTGG
TTATGTTCCTATGATCTCTGGCCGTGGTTTAGGTCATACTGGTGGCACGTTAGATAAATTGGAATCCATTGCTGGCTACA
ATATTATGCCAAACAATGATCTTTTTGGAAAAGTAACCAAAGAAGCTGGCGTAGCTATCATTGGTCAAACGGGTGATTTA
GCACCGGCAGATAAGCGTGTTTATGCCACTCGTGATGTAACGGCAACCGTTGATAATATTTCATTGATTACTGCATCTAT
TCTTTCTAAGAAATTAGCCGCAGGTTTAGATTCATTAGTGATGGATGTAAAAGTCGGTTCAGGTGCATTTATGCCGACTT
ATGAGGCATCAGAAGAGCTGGCTAAATCTATCGTAGCTGTTGCTAATGGCGCGGGCACGAAGACGACCGCATTACTGACG
GACATGAATCAAGTATTAGCCTCTACTGCGGGTAATGCATTAGAAGTTCGTGAAGCGATTCGTTTCCTAACTGGCGAATA
CCGTAATCCTCGTTTATATGAAGTTGCGATGGCGCTATGTGCTGAAATGCTTGTGATTGCGAACTTAGCAAAAGACGAAC
AAGAAGCGTGTATTAAATTGCAAGCAGTGTTAGACAACGGCAAAGCCGCAGAATGTTTTGGTAAAATGGTGTTTGGTCTT
GGTGGACCAAATGACATTATCGAAAATTACGATAACCATTTAGAAACCGCGCAAATCATTAAACCTGTATTTGCAGACAA
ATCCGGCTTTGTTAATACGATGGATACGCGTGATTTAGGCATGGCAGTCGTTGGTATGGGGGGCGGTCGTCGTGTTGCTA
GCGATACTATTGATTATGCGGTTGGGTTAAGTGATATGATTCGTTTAGGTCAAACCGTTGATAGCAATCAACCATTAGCG
ATGATCCATGCTCGTAATGAAGATCAATGGCAGCAGGCTGCAGATGCAGTTAAAGCCGCTATCGTGATCAGCGAAGAACA
ACCAGAAGCGACACCGGAAGTTTATCGTAAAGTTCGCTCACAAGATGTGTAA

Upstream 100 bases:

>100_bases
TTTATATCGATAAATAAATCGACTTAGGTGAGGCATTACCGCTTCACCTACCTCAACCCTACCTATATTAATTTACCCAA
CCAAGATTGGGGAGGCACTA

Downstream 100 bases:

>100_bases
GGAAGAAACCATGAAACGTGCAATTATTTTAGTTCTTGATTCATTTGGTATTGGTGCAGCAGGTGATGCTGAAAAATTTG
GTGATGTGGGTTCAGATACA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MYLPQEIIRRKRDNKVLTTEEINFFIQGVAKNTVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNIMPNNDLFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVAMALCAEMLVIANLAKDEQEACIKLQAVLDNGKAAECFGKMVFGL
GGPNDIIENYDNHLETAQIIKPVFADKSGFVNTMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTVDSNQPLA
MIHARNEDQWQQAADAVKAAIVISEEQPEATPEVYRKVRSQDV

Sequences:

>Translated_443_residues
MYLPQEIIRRKRDNKVLTTEEINFFIQGVAKNTVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNIMPNNDLFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVAMALCAEMLVIANLAKDEQEACIKLQAVLDNGKAAECFGKMVFGL
GGPNDIIENYDNHLETAQIIKPVFADKSGFVNTMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTVDSNQPLA
MIHARNEDQWQQAADAVKAAIVISEEQPEATPEVYRKVRSQDV
>Mature_443_residues
MYLPQEIIRRKRDNKVLTTEEINFFIQGVAKNTVSEGQIAAFAMAVYFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGP
IVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLESIAGYNIMPNNDLFGKVTKEAGVAIIGQTGDL
APADKRVYATRDVTATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVAMALCAEMLVIANLAKDEQEACIKLQAVLDNGKAAECFGKMVFGL
GGPNDIIENYDNHLETAQIIKPVFADKSGFVNTMDTRDLGMAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTVDSNQPLA
MIHARNEDQWQQAADAVKAAIVISEEQPEATPEVYRKVRSQDV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=445, Percent_Identity=37.0786516853933, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4503445, Length=445, Percent_Identity=37.0786516853933, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI166158922, Length=445, Percent_Identity=37.0786516853933, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=70.5479452054795, Blast_Score=638, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_ALISL (B6ENG4)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262140.1
- GeneID:   6988403
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0620
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- ProtClustDB:   PRK05820
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 47492; Mature: 47492

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLPQEIIRRKRDNKVLTTEEINFFIQGVAKNTVSEGQIAAFAMAVYFNEMTMPERIALT
CCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
CAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLESIAGYNIMPNNDLFGKVTKEAGVAIIGQTGDLAPADKRVYATRDVTATVDNI
CCCHHHHHHHCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCEEEECCCEEEHHHH
SLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVAMALCAEMLVIANLAKDEQEACIKL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QAVLDNGKAAECFGKMVFGLGGPNDIIENYDNHLETAQIIKPVFADKSGFVNTMDTRDLG
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCC
MAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTVDSNQPLAMIHARNEDQWQQAADAVKAA
EEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHEE
IVISEEQPEATPEVYRKVRSQDV
EEEECCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MYLPQEIIRRKRDNKVLTTEEINFFIQGVAKNTVSEGQIAAFAMAVYFNEMTMPERIALT
CCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
CAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLESIAGYNIMPNNDLFGKVTKEAGVAIIGQTGDLAPADKRVYATRDVTATVDNI
CCCHHHHHHHCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCEEEECCCEEEHHHH
SLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEASEELAKSIVAVANGAGTKTTALLT
HHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
DMNQVLASTAGNALEVREAIRFLTGEYRNPRLYEVAMALCAEMLVIANLAKDEQEACIKL
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QAVLDNGKAAECFGKMVFGLGGPNDIIENYDNHLETAQIIKPVFADKSGFVNTMDTRDLG
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCC
MAVVGMGGGRRVASDTIDYAVGLSDMIRLGQTVDSNQPLAMIHARNEDQWQQAADAVKAA
EEEEECCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHEE
IVISEEQPEATPEVYRKVRSQDV
EEEECCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA