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The map label for this gene is epd

Identifier: 209694148

GI number: 209694148

Start: 607905

End: 608924

Strand: Direct

Name: epd

Synonym: VSAL_I0555

Alternate gene names: 209694148

Gene position: 607905-608924 (Clockwise)

Preceding gene: 209694147

Following gene: 209694149

Centisome position: 18.28

GC content: 39.02

Gene sequence:

>1020_bases
ATGTTAAGAGTGGCGATAAATGGATTTGGTCGAATTGGTCGTAGTGTATTACGTGCTTTGTATGAAAGTGGTAAGCGTGA
TCAAATTGAAATCGTGGCTGTGAATGAATTATCACAACCAGAAGGAATGGCGCACCTTCTTCAATACGATTCAACTCATG
GACGTTTTCTGCATAAAGTCACCCATGATCAAGAATATCTTTATATCGATTTACCTAATGGCTCTCAAGATCGAATTCGT
ATTGTACATCAAGCCGATATTTCTCTTTTGCCATGGCAATCATTGCAAGTAGATTTAGTGCTGGATTGCACTGGTGTTTA
TGGATCTAAAGCGGATGGCGAGAGGCACATTGATGCGGGGGCTAAAAAGGTTTTATTTTCACACCCAGGAAGCGCAGACT
TAGATAACACTATCATTTACGGTGTTAATCATGACACATTGCTTCCTGAGCATAGAGTTGTCTCTAATGGGTCTTGTACT
ACTAACTGTATTATCCCAGTGATTAAGGCGATTGATGATGCGTTTGGTATTGAATCTGGCACGATTACGACGATTCACTC
TGCGATGAATGATCAACCAGTGATTGATGCGTATCATACTGATTTACGTCGAACTCGAGCAGCAAGCCAGTCTATAATTC
CAGTAGATACAAAACTGCATAAAGGTATTGAACGAATTTTTCCGAAATTTTCCAACAAATTTGAGGCTATTTCTGTGCGA
GTACCGACGGTAAACGTCACTGCGATGGATTTAAGTGTAACAATTAATACAAATGTGAAAGTTAATGACATAAATCAAAC
CATTGTTAATGCATCTCAGTGTACATTACATAACATTGTTGATTATACTGAAGCGCCACTTGTTTCTATCGACTTTAATC
ATGATCCCCATAGCGCGATTGTCGATGGTTCACAAACAAGAGTTAGTAACGGGCATTTAGTTAAAATGCTGGTTTGGTGT
GATAACGAATGGGGCTTTGCTAATCGGATGCTAGATACCGCATTAGTAATGAAAAAATAA

Upstream 100 bases:

>100_bases
AAAAGCGAAGTTATCGAAAGGTGGCTTCGCTTTTTTGATCCTTTAAGAAAAAAGTGAAAAGAGTACAATAGACGAAAAAT
AAACCTGAGTGAATGGAATT

Downstream 100 bases:

>100_bases
AAGCATCAATCAAATAATTTGTGATGGAAAGAGAAAAAAGATTAATTTTCACCTTGAAAAAAGTGAACTCCATCCCTATT
TATTGAATAATGCAGTAAGA

Product: erythrose 4-phosphate dehydrogenase

Products: NA

Alternate protein names: E4PDH

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLRVAINGFGRIGRSVLRALYESGKRDQIEIVAVNELSQPEGMAHLLQYDSTHGRFLHKVTHDQEYLYIDLPNGSQDRIR
IVHQADISLLPWQSLQVDLVLDCTGVYGSKADGERHIDAGAKKVLFSHPGSADLDNTIIYGVNHDTLLPEHRVVSNGSCT
TNCIIPVIKAIDDAFGIESGTITTIHSAMNDQPVIDAYHTDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASQCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALVMKK

Sequences:

>Translated_339_residues
MLRVAINGFGRIGRSVLRALYESGKRDQIEIVAVNELSQPEGMAHLLQYDSTHGRFLHKVTHDQEYLYIDLPNGSQDRIR
IVHQADISLLPWQSLQVDLVLDCTGVYGSKADGERHIDAGAKKVLFSHPGSADLDNTIIYGVNHDTLLPEHRVVSNGSCT
TNCIIPVIKAIDDAFGIESGTITTIHSAMNDQPVIDAYHTDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASQCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALVMKK
>Mature_339_residues
MLRVAINGFGRIGRSVLRALYESGKRDQIEIVAVNELSQPEGMAHLLQYDSTHGRFLHKVTHDQEYLYIDLPNGSQDRIR
IVHQADISLLPWQSLQVDLVLDCTGVYGSKADGERHIDAGAKKVLFSHPGSADLDNTIIYGVNHDTLLPEHRVVSNGSCT
TNCIIPVIKAIDDAFGIESGTITTIHSAMNDQPVIDAYHTDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASQCTLHNIVDYTEAPLVSIDFNHDPHSAIVDGSQTRVSNGHLVKMLVWC
DNEWGFANRMLDTALVMKK

Specific function: Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily

Homologues:

Organism=Homo sapiens, GI7669492, Length=333, Percent_Identity=38.4384384384384, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI7657116, Length=334, Percent_Identity=36.5269461077844, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1789295, Length=336, Percent_Identity=68.4523809523809, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1788079, Length=334, Percent_Identity=38.622754491018, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17534677, Length=332, Percent_Identity=39.1566265060241, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17534679, Length=332, Percent_Identity=38.855421686747, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17568413, Length=334, Percent_Identity=38.622754491018, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI32566163, Length=334, Percent_Identity=38.622754491018, Blast_Score=234, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6322409, Length=334, Percent_Identity=39.8203592814371, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322468, Length=334, Percent_Identity=38.622754491018, Blast_Score=252, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6321631, Length=334, Percent_Identity=39.2215568862275, Blast_Score=252, Evalue=6e-68,
Organism=Drosophila melanogaster, GI19922412, Length=337, Percent_Identity=36.2017804154303, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI85725000, Length=334, Percent_Identity=37.4251497005988, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI22023983, Length=334, Percent_Identity=37.4251497005988, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17933600, Length=340, Percent_Identity=36.4705882352941, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI18110149, Length=340, Percent_Identity=36.4705882352941, Blast_Score=220, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): E4PD_ALISL (B6EMW1)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262076.1
- GeneID:   6989299
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0555
- HOGENOM:   HBG571736
- OMA:   IQAKAVR
- ProtClustDB:   PRK13535
- GO:   GO:0005737
- HAMAP:   MF_01640
- InterPro:   IPR006422
- InterPro:   IPR020831
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10836
- PIRSF:   PIRSF000149
- PRINTS:   PR00078
- SMART:   SM00846
- TIGRFAMs:   TIGR01532

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N

EC number: =1.2.1.72

Molecular weight: Translated: 37597; Mature: 37597

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00071 GAPDH

Important sites: ACT_SITE 159-159 BINDING 204-204 BINDING 240-240 BINDING 322-322

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVAINGFGRIGRSVLRALYESGKRDQIEIVAVNELSQPEGMAHLLQYDSTHGRFLHKV
CEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEE
THDQEYLYIDLPNGSQDRIRIVHQADISLLPWQSLQVDLVLDCTGVYGSKADGERHIDAG
CCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCEEEEEEEECCCCCCCCCCCHHHCCC
AKKVLFSHPGSADLDNTIIYGVNHDTLLPEHRVVSNGSCTTNCIIPVIKAIDDAFGIESG
CCEEEEECCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC
TITTIHSAMNDQPVIDAYHTDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
CEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEE
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASQCTLHNIVDYTEAPLVSIDFNHDPHSAI
ECEEEEEEEEEEEEEECCEEEECCHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCEE
VDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALVMKK
ECCCCEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRVAINGFGRIGRSVLRALYESGKRDQIEIVAVNELSQPEGMAHLLQYDSTHGRFLHKV
CEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEE
THDQEYLYIDLPNGSQDRIRIVHQADISLLPWQSLQVDLVLDCTGVYGSKADGERHIDAG
CCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCEEEEEEEECCCCCCCCCCCHHHCCC
AKKVLFSHPGSADLDNTIIYGVNHDTLLPEHRVVSNGSCTTNCIIPVIKAIDDAFGIESG
CCEEEEECCCCCCCCCEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCC
TITTIHSAMNDQPVIDAYHTDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVR
CEEEEEHHCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEE
VPTVNVTAMDLSVTINTNVKVNDINQTIVNASQCTLHNIVDYTEAPLVSIDFNHDPHSAI
ECEEEEEEEEEEEEEECCEEEECCHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCEE
VDGSQTRVSNGHLVKMLVWCDNEWGFANRMLDTALVMKK
ECCCCEEECCCCEEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA