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The map label for this gene is fklB [H]

Identifier: 209694007

GI number: 209694007

Start: 444332

End: 444952

Strand: Reverse

Name: fklB [H]

Synonym: VSAL_I0406

Alternate gene names: 209694007

Gene position: 444952-444332 (Counterclockwise)

Preceding gene: 209694009

Following gene: 209694006

Centisome position: 13.38

GC content: 46.22

Gene sequence:

>621_bases
ATGTCTGAAGTTAAATTAGAAACAGTTGAGCAAAGAGCAAGCTACGGTATTGGTCTACAAATGGGCCAACAACTTGCACA
ATCTGGTCTTGAAGGCCTAAACGTTGCAGCGATCGCTAAAGGCATCGCAACTTCACTAACTGGCGACATGCCAGAAATCG
AAGTTGACGCAATCAACGAAGCACTTCAAGCGCTTCACATGCGTGCTGAAGAAACTCGTGCTGAAGCATCTAAAGCAGCT
GCTGCTGACGGCGAAACGTTCCTAGCGGACAACGCACTACGTTCAGAAGTTACTGTACTTGAGTCTGGTCTTCAATATGA
AGTACTAACTGAAGGTACTGGTGAAATTCCAACTTCTGATAAAACAGTACGTGTTCACTACCACGGTATGCTAACTGACG
GTTCTGTATTCGACAGTTCTGTAGAACGCGGCCAACCTGCTGAATTCCCAGTAACTGGCGTTATCGCTGGTTGGGTTGAA
GCTCTTCAACTAATGCCTGTAGGATCTAAGTGGAAGCTTTCTATCCCACAAGACCTAGCATACGGTGAGCGTGGCGCTGG
CGCTGCAATCCCTCCATATGCAGCACTAGTATTTGAAGTAGAACTACTAGACATTCTTTAA

Upstream 100 bases:

>100_bases
TCTAATATCAGAGTGCAAAGAAGTACAAAAGTTTACCTTAAGCTTAGATCTCTGTATCCTTTATCTCTTCGTTTATACCA
TATAAAGAAAGAGAGACAGC

Downstream 100 bases:

>100_bases
TCTTTCTCAAAAAAGATTAAAAATAAAATAAGAAAGCGATGCCTATGGGCATCGCTTTTTTTTATGTCATACTCTAACGG
TATGTTACGAAAATAAAACC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEETRAEASKAA
AADGETFLADNALRSEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTDGSVFDSSVERGQPAEFPVTGVIAGWVE
ALQLMPVGSKWKLSIPQDLAYGERGAGAAIPPYAALVFEVELLDIL

Sequences:

>Translated_206_residues
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEETRAEASKAA
AADGETFLADNALRSEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTDGSVFDSSVERGQPAEFPVTGVIAGWVE
ALQLMPVGSKWKLSIPQDLAYGERGAGAAIPPYAALVFEVELLDIL
>Mature_205_residues
SEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINEALQALHMRAEETRAEASKAAA
ADGETFLADNALRSEVTVLESGLQYEVLTEGTGEIPTSDKTVRVHYHGMLTDGSVFDSSVERGQPAEFPVTGVIAGWVEA
LQLMPVGSKWKLSIPQDLAYGERGAGAAIPPYAALVFEVELLDIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=40.5660377358491, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=54.1176470588235, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=54.1176470588235, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=54.1176470588235, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4503727, Length=125, Percent_Identity=40, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4503729, Length=101, Percent_Identity=41.5841584158416, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI192448443, Length=88, Percent_Identity=44.3181818181818, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=58.252427184466, Blast_Score=247, Evalue=3e-67,
Organism=Escherichia coli, GI1789745, Length=214, Percent_Identity=35.0467289719626, Blast_Score=108, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=43.3962264150943, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=44.7058823529412, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=40, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=86, Percent_Identity=54.6511627906977, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=40.9090909090909, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281363946, Length=87, Percent_Identity=49.4252873563218, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17352457, Length=87, Percent_Identity=49.4252873563218, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=42.4528301886792, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=41.5094339622642, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647110, Length=94, Percent_Identity=42.5531914893617, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21845; Mature: 21714

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINE
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
ALQALHMRAEETRAEASKAAAADGETFLADNALRSEVTVLESGLQYEVLTEGTGEIPTSD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
KTVRVHYHGMLTDGSVFDSSVERGQPAEFPVTGVIAGWVEALQLMPVGSKWKLSIPQDLA
CEEEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHC
YGERGAGAAIPPYAALVFEVELLDIL
CCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVKLETVEQRASYGIGLQMGQQLAQSGLEGLNVAAIAKGIATSLTGDMPEIEVDAINE
CCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
ALQALHMRAEETRAEASKAAAADGETFLADNALRSEVTVLESGLQYEVLTEGTGEIPTSD
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
KTVRVHYHGMLTDGSVFDSSVERGQPAEFPVTGVIAGWVEALQLMPVGSKWKLSIPQDLA
CEEEEEEEEEECCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHC
YGERGAGAAIPPYAALVFEVELLDIL
CCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]