Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 209693972

GI number: 209693972

Start: 403036

End: 404025

Strand: Reverse

Name: pdxA [H]

Synonym: VSAL_I0369

Alternate gene names: 209693972

Gene position: 404025-403036 (Counterclockwise)

Preceding gene: 209693973

Following gene: 209693971

Centisome position: 12.15

GC content: 40.61

Gene sequence:

>990_bases
ATGAATAATATAAAACGCATAGCAATCACACCGGGAGAACCCGCGGGCATCGGCCCTGATCTTGTTCTGTCTATTGCTCA
ACAAGATTGGCCTCATCAATTGGTTATCTGTGGTAATCGAACGGCATTAGAACAAAGAGCAAAACAATTAAAGTTATCAA
TTAATATTGAAAACTACGATGTAAATACACCCGCAAAATCTCATCGTGCAGGAACATTAATTGTAGATAACATTGAATTA
GGCATAGACGTTATTGCTGGCGAGTTAAACGAAGCGAATGGTCACTATGTATTAGAAACCCTAACGCGCGCCGCTCAAGG
TAATATGGATGGCGAGTTTGATGCCGTAGTTACCGGCCCAGTACACAAAGGGGTAATTAATCGTGCAGGTGTTGCTTTTA
GTGGCCATACCGAGTTCTTTGCCGAATTATCGAATACACAACAAGTTGTAATGATGCTAGCAACAGAAGGACTTCGTGTT
GCGTTAGTAACGACTCACATACCTTTGGCTTATGTCGCTAAAGCAATTACTGATGACCGATTAAAACAAGTTATTCGAAT
CTTACATCAAGATTTAATCACTAAGTTTGGCATCACTAATCCAGCTATTTTTGTCTGTGGTTTAAACCCACATGCAGGTG
AAGATGGCTGTCTTGGTCGTGAAGAAATTGATATCATTACACCTGCACTAAATGATTTACGTGAAAAAGAAAGCATGAAC
CTTATTGGTCCTTTGCCCGCTGACACGTTATTTCAAGATAAATACTTACAAGAAGCTGATGCCGTGCTCGCGATGTATCA
CGATCAAGGGCTTCCTGTGTTAAAATTTAAAGGATTTGGAAAGTCGGTGAACATTACATTAGGTTTGCCTTTTATCCGAA
CTTCCGTAGACCACGGTACTGCATTGGAATTAGCGGGTACTGGAAAAGCAGATGCAGGAAGCTTTATTACCGCACTTACC
CATGCAATTGAACTGGTAGAAAATAAATGA

Upstream 100 bases:

>100_bases
ATGAATCGCAAGTTTAACGAAGAGTCAGGCGCTTGGTTACAAGAAATCAGAGCGAGTGCTTACGTCGAAATTCTGCAAGA
TAATGATGACAGTGATGAAA

Downstream 100 bases:

>100_bases
GTACAAGAAATGATGTCCATTTAGGCCATAAAGCGAAGAAACGCTTTGGTCAAAACTTCTTAAACGACCCTTACGTAATC
GATGGAATCGTATCTGCAAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MNNIKRIAITPGEPAGIGPDLVLSIAQQDWPHQLVICGNRTALEQRAKQLKLSINIENYDVNTPAKSHRAGTLIVDNIEL
GIDVIAGELNEANGHYVLETLTRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAELSNTQQVVMMLATEGLRV
ALVTTHIPLAYVAKAITDDRLKQVIRILHQDLITKFGITNPAIFVCGLNPHAGEDGCLGREEIDIITPALNDLREKESMN
LIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSFITALT
HAIELVENK

Sequences:

>Translated_329_residues
MNNIKRIAITPGEPAGIGPDLVLSIAQQDWPHQLVICGNRTALEQRAKQLKLSINIENYDVNTPAKSHRAGTLIVDNIEL
GIDVIAGELNEANGHYVLETLTRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAELSNTQQVVMMLATEGLRV
ALVTTHIPLAYVAKAITDDRLKQVIRILHQDLITKFGITNPAIFVCGLNPHAGEDGCLGREEIDIITPALNDLREKESMN
LIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSFITALT
HAIELVENK
>Mature_329_residues
MNNIKRIAITPGEPAGIGPDLVLSIAQQDWPHQLVICGNRTALEQRAKQLKLSINIENYDVNTPAKSHRAGTLIVDNIEL
GIDVIAGELNEANGHYVLETLTRAAQGNMDGEFDAVVTGPVHKGVINRAGVAFSGHTEFFAELSNTQQVVMMLATEGLRV
ALVTTHIPLAYVAKAITDDRLKQVIRILHQDLITKFGITNPAIFVCGLNPHAGEDGCLGREEIDIITPALNDLREKESMN
LIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGTALELAGTGKADAGSFITALT
HAIELVENK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=328, Percent_Identity=64.0243902439024, Blast_Score=421, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35521; Mature: 35521

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIKRIAITPGEPAGIGPDLVLSIAQQDWPHQLVICGNRTALEQRAKQLKLSINIENYD
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHEEEEEEEEEEEE
VNTPAKSHRAGTLIVDNIELGIDVIAGELNEANGHYVLETLTRAAQGNMDGEFDAVVTGP
CCCCCCCCCCCEEEEECEEECEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECC
VHKGVINRAGVAFSGHTEFFAELSNTQQVVMMLATEGLRVALVTTHIPLAYVAKAITDDR
HHHHHHHHCCEEECCCHHHHHHHCCHHHEEHEEECCCCEEEEEEECCCHHHHHHHHCHHH
LKQVIRILHQDLITKFGITNPAIFVCGLNPHAGEDGCLGREEIDIITPALNDLREKESMN
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHHHHHHHCCC
LIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGT
EECCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEEEEECHHHEECCCCCC
ALELAGTGKADAGSFITALTHAIELVENK
EEEEECCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNIKRIAITPGEPAGIGPDLVLSIAQQDWPHQLVICGNRTALEQRAKQLKLSINIENYD
CCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHEEEEEEEEEEEE
VNTPAKSHRAGTLIVDNIELGIDVIAGELNEANGHYVLETLTRAAQGNMDGEFDAVVTGP
CCCCCCCCCCCEEEEECEEECEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECC
VHKGVINRAGVAFSGHTEFFAELSNTQQVVMMLATEGLRVALVTTHIPLAYVAKAITDDR
HHHHHHHHCCEEECCCHHHHHHHCCHHHEEHEEECCCCEEEEEEECCCHHHHHHHHCHHH
LKQVIRILHQDLITKFGITNPAIFVCGLNPHAGEDGCLGREEIDIITPALNDLREKESMN
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHHHHHHHCCC
LIGPLPADTLFQDKYLQEADAVLAMYHDQGLPVLKFKGFGKSVNITLGLPFIRTSVDHGT
EECCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCEEEEEEECHHHEECCCCCC
ALELAGTGKADAGSFITALTHAIELVENK
EEEEECCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]