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The map label for this gene is apaH

Identifier: 209693970

GI number: 209693970

Start: 401288

End: 402109

Strand: Reverse

Name: apaH

Synonym: VSAL_I0367

Alternate gene names: 209693970

Gene position: 402109-401288 (Counterclockwise)

Preceding gene: 209693971

Following gene: 209693963

Centisome position: 12.09

GC content: 40.39

Gene sequence:

>822_bases
ATGGCGACCTATTTTGTTGGCGATATTCAAGGCTGTCTAGACGAGCTATTGTTATTACTCGATCAGGTCAGCTTTGATAA
AGAAAAAGATCAACTTTGGTTAACTGGAGATCTTGTTGCTCGTGGACCAAAATCTTTAGAAACTCTTCGCTTTGTAAAAT
CATTAGATAAAGCCGCCGTGACCATTCTTGGCAATCATGATCTTCATCTGCTCGCGGTATCTCAAGGTATTTCACGCATA
AAAGAAAAAGATAAAACGGCCTCTATTTTTACCGCGCCTGATAGTGAAGAATTACTTACTTGGCTACGCCATCAACCATT
ATTAGCGACTCACGCTCAGCATAATATTGTCATGACTCATGCTGGGATCTCTCCGCAGTGGAATATAGAAACTGCCACTG
AATGCGCTCGTGAAATTGAATCTGTTTTAGTTTCTGACAAATGGGTATGGTTATTAGAAAACATGTATGAGAATCAACCT
GATTTATGGCAAAGCGATCTTACTGGTATAAACCGTTATCGTTACATAATTAACGCGTTTACACGTATGCGTTTCTGTTA
CCCAGACGGACGTCTAGATATGGAATGCAAACAGCCACCACAAGAATTATCTTCAGACGATAAAGAAAAACTAATTCCGT
GGTTTGATCTTAAGTCTCGATGCCCTCTTTCTCACACTGTGATCTTTGGTCATTGGGCTGCATTGATGGGTTATGAAAAC
AATGGCGTAATAGCATTAGATACAGGCTGTGTCTGGGGGGAATATATGACGATGTATCGAGTCGATGATGGACAATATTT
CACACAAAAGGCGATAAGCTAG

Upstream 100 bases:

>100_bases
TTAACTTAGTGGCTCATCCTTAACGAACACAATAAAATAAAAGGTGACTTCATTGTCACCTTTTTTCTATCTACTCCCAT
ATTGATGTAAGGAAATATTC

Downstream 100 bases:

>100_bases
AAACTATACGCTTCGCTAACTAGAGACTATAAAAGCAAAAGATAGACGGCTTCGCCTTGAGAGCGCTTCGCTATAAGACG
CAACAAGTTGTTTGAGGGGT

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MATYFVGDIQGCLDELLLLLDQVSFDKEKDQLWLTGDLVARGPKSLETLRFVKSLDKAAVTILGNHDLHLLAVSQGISRI
KEKDKTASIFTAPDSEELLTWLRHQPLLATHAQHNIVMTHAGISPQWNIETATECAREIESVLVSDKWVWLLENMYENQP
DLWQSDLTGINRYRYIINAFTRMRFCYPDGRLDMECKQPPQELSSDDKEKLIPWFDLKSRCPLSHTVIFGHWAALMGYEN
NGVIALDTGCVWGEYMTMYRVDDGQYFTQKAIS

Sequences:

>Translated_273_residues
MATYFVGDIQGCLDELLLLLDQVSFDKEKDQLWLTGDLVARGPKSLETLRFVKSLDKAAVTILGNHDLHLLAVSQGISRI
KEKDKTASIFTAPDSEELLTWLRHQPLLATHAQHNIVMTHAGISPQWNIETATECAREIESVLVSDKWVWLLENMYENQP
DLWQSDLTGINRYRYIINAFTRMRFCYPDGRLDMECKQPPQELSSDDKEKLIPWFDLKSRCPLSHTVIFGHWAALMGYEN
NGVIALDTGCVWGEYMTMYRVDDGQYFTQKAIS
>Mature_272_residues
ATYFVGDIQGCLDELLLLLDQVSFDKEKDQLWLTGDLVARGPKSLETLRFVKSLDKAAVTILGNHDLHLLAVSQGISRIK
EKDKTASIFTAPDSEELLTWLRHQPLLATHAQHNIVMTHAGISPQWNIETATECAREIESVLVSDKWVWLLENMYENQPD
LWQSDLTGINRYRYIINAFTRMRFCYPDGRLDMECKQPPQELSSDDKEKLIPWFDLKSRCPLSHTVIFGHWAALMGYENN
GVIALDTGCVWGEYMTMYRVDDGQYFTQKAIS

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family

Homologues:

Organism=Escherichia coli, GI1786234, Length=272, Percent_Identity=52.2058823529412, Blast_Score=300, Evalue=5e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APAH_ALISL (B6EL47)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002261898.1
- GeneID:   6988552
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0367
- HOGENOM:   HBG724457
- OMA:   LVFGHWA
- ProtClustDB:   PRK00166
- HAMAP:   MF_00199
- InterPro:   IPR004617
- InterPro:   IPR004843
- PIRSF:   PIRSF000903
- TIGRFAMs:   TIGR00668

Pfam domain/function: PF00149 Metallophos

EC number: =3.6.1.41

Molecular weight: Translated: 31306; Mature: 31175

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYFVGDIQGCLDELLLLLDQVSFDKEKDQLWLTGDLVARGPKSLETLRFVKSLDKAAV
CCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHEE
TILGNHDLHLLAVSQGISRIKEKDKTASIFTAPDSEELLTWLRHQPLLATHAQHNIVMTH
EEECCCCEEEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEECCCCCEEEEE
AGISPQWNIETATECAREIESVLVSDKWVWLLENMYENQPDLWQSDLTGINRYRYIINAF
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TRMRFCYPDGRLDMECKQPPQELSSDDKEKLIPWFDLKSRCPLSHTVIFGHWAALMGYEN
HHHEEECCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEECC
NGVIALDTGCVWGEYMTMYRVDDGQYFTQKAIS
CCEEEEECCCCCCCEEEEEEECCCCHHHHHCCC
>Mature Secondary Structure 
ATYFVGDIQGCLDELLLLLDQVSFDKEKDQLWLTGDLVARGPKSLETLRFVKSLDKAAV
CEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHEE
TILGNHDLHLLAVSQGISRIKEKDKTASIFTAPDSEELLTWLRHQPLLATHAQHNIVMTH
EEECCCCEEEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCEEECCCCCEEEEE
AGISPQWNIETATECAREIESVLVSDKWVWLLENMYENQPDLWQSDLTGINRYRYIINAF
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TRMRFCYPDGRLDMECKQPPQELSSDDKEKLIPWFDLKSRCPLSHTVIFGHWAALMGYEN
HHHEEECCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHEEECC
NGVIALDTGCVWGEYMTMYRVDDGQYFTQKAIS
CCEEEEECCCCCCCEEEEEEECCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA