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The map label for this gene is pyrE [H]

Identifier: 209693819

GI number: 209693819

Start: 247781

End: 248290

Strand: Reverse

Name: pyrE [H]

Synonym: VSAL_I0206

Alternate gene names: 209693819

Gene position: 248290-247781 (Counterclockwise)

Preceding gene: 209693820

Following gene: 209693817

Centisome position: 7.47

GC content: 44.71

Gene sequence:

>510_bases
ATGAAAGCATACCAGCGTGAGTTTATTGAATTTGCCCTTGAGAAAGAAGTATTAAAGTTTGGTGAGTTTACTTTAAAGTC
TGGCCGTATAAGCCCATATTTTTTCAACGCTGGTCTGTTCAATACCGGTCGTGATTTAGCGCGCTTAGGCCGTTTTTATG
CCGCGGCATTAGTTGAATCAGGTATTGATTATGATGTGCTATTTGGCCCTGCGTACAAAGGCATTCCAATCGCAACGACA
ACCGCAGTAGCCTTAGCGGATCACCACGATACGGATAAGCCATATTGCTTTAACCGTAAAGAAGCAAAGAATCATGGTGA
AGGTGGCAACCTAGTTGGTAGCGCACTTGAAGGTCGCATCATGTTGGTTGATGACGTGATCACAGCAGGAACCGCAATCC
GTGAATCAATGGAAATTATCCAAGCAAACGGCGCTGATCTTGCTGGTGTCTTGTGGCAATCGATCGCCAAGAAAAAGGCA
AAGGCGAATTATCTGCGATTCAAGAAGTAG

Upstream 100 bases:

>100_bases
TCGATGTTCGCTCTTATAGTCTCTAGGCGAAGCAATATAGTTAGCGTAGCGTATAGTTTTTTATTTTAAATATCACAATA
CCAAAAAAGAGAGAATGAAG

Downstream 100 bases:

>100_bases
AGCGTGATTTTGGTTGCTCAATTATCTCAATCGTAAGCTTAACTGACCTGATCTCTTTCTTAGAAGAGAAAGGCGGCAAT
GCTGAGCAACTTGAGTCAGT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MKAYQREFIEFALEKEVLKFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVESGIDYDVLFGPAYKGIPIATT
TAVALADHHDTDKPYCFNRKEAKNHGEGGNLVGSALEGRIMLVDDVITAGTAIRESMEIIQANGADLAGVLWQSIAKKKA
KANYLRFKK

Sequences:

>Translated_169_residues
MKAYQREFIEFALEKEVLKFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVESGIDYDVLFGPAYKGIPIATT
TAVALADHHDTDKPYCFNRKEAKNHGEGGNLVGSALEGRIMLVDDVITAGTAIRESMEIIQANGADLAGVLWQSIAKKKA
KANYLRFKK
>Mature_169_residues
MKAYQREFIEFALEKEVLKFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVESGIDYDVLFGPAYKGIPIATT
TAVALADHHDTDKPYCFNRKEAKNHGEGGNLVGSALEGRIMLVDDVITAGTAIRESMEIIQANGADLAGVLWQSIAKKKA
KANYLRFKK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=131, Percent_Identity=28.2442748091603, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1790073, Length=151, Percent_Identity=88.0794701986755, Blast_Score=278, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17508631, Length=139, Percent_Identity=30.2158273381295, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323530, Length=153, Percent_Identity=54.2483660130719, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323927, Length=155, Percent_Identity=49.6774193548387, Blast_Score=156, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 18645; Mature: 18645

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYQREFIEFALEKEVLKFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVES
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
GIDYDVLFGPAYKGIPIATTTAVALADHHDTDKPYCFNRKEAKNHGEGGNLVGSALEGRI
CCCEEEEECCCCCCCCCHHHHHEEEECCCCCCCCCCCCCHHHHCCCCCCCEEHHHHCCCE
MLVDDVITAGTAIRESMEIIQANGADLAGVLWQSIAKKKAKANYLRFKK
EEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAYQREFIEFALEKEVLKFGEFTLKSGRISPYFFNAGLFNTGRDLARLGRFYAAALVES
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHC
GIDYDVLFGPAYKGIPIATTTAVALADHHDTDKPYCFNRKEAKNHGEGGNLVGSALEGRI
CCCEEEEECCCCCCCCCHHHHHEEEECCCCCCCCCCCCCHHHHCCCCCCCEEHHHHCCCE
MLVDDVITAGTAIRESMEIIQANGADLAGVLWQSIAKKKAKANYLRFKK
EEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA