Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 209693704

GI number: 209693704

Start: 82555

End: 83673

Strand: Reverse

Name: purK [H]

Synonym: VSAL_I0080

Alternate gene names: 209693704

Gene position: 83673-82555 (Counterclockwise)

Preceding gene: 209693705

Following gene: 209693699

Centisome position: 2.52

GC content: 38.78

Gene sequence:

>1119_bases
ATGATGAAAGTTCTTGTACTCGGTTCTGGTCAACTCGCTCGCATGATGTCTTTAGCGAGTGCTCCACTAAATATCGACAT
TATCGCTTATGATGTGAACAACAACAAAATTGTACACCCATTAACGCAACAGGTCATGGATACGACTTTAGAGCAAACAA
TTAATAGCGTTGATGTTATTACCGCAGAATTTGAACACATTCCTTACGACATCTTAGATATTTGCAGTCAAAGTGGTAAG
TTTCAGCCAAACCCCGAAGCCATTAAAGCTGGCGGCGATCGTCGTATTGAGAAAACACTACTTGATAATGCCAATGTGGC
CAATGCAACACACCATATAATTACAACTAAGCAAGAGTTCTTAGACTCAATTAGTAGCGTAGGTCTTCCTATGGTGTTAA
AAAGTGCTCTAGGTGGGTACGACGGAAAAGGGCAATGGCGCTTAAAGGAAGCTTCTCAAATTGATCATATTTGGGAAGAA
ATGAATGAACTAATTCAGAGCACACCAAATCAAGCCATCGTTGCTGAGCAATTTATTCCGTTTAATCGCGAAGTTTCTTT
AATTGGTGCCCGTAATAAGAATGGCGATATAGTGACATACCCATTAACAGAGAACGTTCATGTTAATGGTGTATTAGCGT
TATCTACCGCATTAGAAGGAACAAGCTTATTACAGCAACAAGCTGATGACATGTTCTCTGCAATCGTGAATGAACTCGAT
TATATTGGCGTACTTGCTATTGAGTTTTTTGATGTAGATGGTCAACTGCTCGTTAATGAAATTGCACCTAGAGTACATAA
CTCTGGTCATTGGACCCAACAGGGAACCGATGTATGTCAATTTGAAATGCATATTCGTGCAGTATGTAATTTACCATTAG
TCGGAGCAGAATTGATTCGTTCAACCGCCATGATTAATATCTTAGGTGAAGACTCTTTACCGAAAGAACTCCTCACTATG
CCTCATTGCCATATTCACTGGTATGGCAAAGAAAAACGTGTTGGTAGGAAGATGGGACATATAAATGTATGTGCATCATC
ACCAGAGGCTTTAGAAAAAGAATTAATGGCACTCTCTGAATTATTAGATAAAAATGCATTTCAAGTATTATCAAAATAA

Upstream 100 bases:

>100_bases
TCATTGGTACGTCAAATGAAGCAGTAATGGCAGCAGTAGAAGCCTTCCGTAAAGAACAAACAGATACTGTCTTAGCAAAT
CCAGATCCATCAGAGGATTA

Downstream 100 bases:

>100_bases
ACAGATACACCTCAATAGAATAGAGCATTCATCAATGCTCTATTTTTTTATATCTTGTACCACACTGCACTTTTTATCTG
CACAAACCAATTTTAAACCT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MMKVLVLGSGQLARMMSLASAPLNIDIIAYDVNNNKIVHPLTQQVMDTTLEQTINSVDVITAEFEHIPYDILDICSQSGK
FQPNPEAIKAGGDRRIEKTLLDNANVANATHHIITTKQEFLDSISSVGLPMVLKSALGGYDGKGQWRLKEASQIDHIWEE
MNELIQSTPNQAIVAEQFIPFNREVSLIGARNKNGDIVTYPLTENVHVNGVLALSTALEGTSLLQQQADDMFSAIVNELD
YIGVLAIEFFDVDGQLLVNEIAPRVHNSGHWTQQGTDVCQFEMHIRAVCNLPLVGAELIRSTAMINILGEDSLPKELLTM
PHCHIHWYGKEKRVGRKMGHINVCASSPEALEKELMALSELLDKNAFQVLSK

Sequences:

>Translated_372_residues
MMKVLVLGSGQLARMMSLASAPLNIDIIAYDVNNNKIVHPLTQQVMDTTLEQTINSVDVITAEFEHIPYDILDICSQSGK
FQPNPEAIKAGGDRRIEKTLLDNANVANATHHIITTKQEFLDSISSVGLPMVLKSALGGYDGKGQWRLKEASQIDHIWEE
MNELIQSTPNQAIVAEQFIPFNREVSLIGARNKNGDIVTYPLTENVHVNGVLALSTALEGTSLLQQQADDMFSAIVNELD
YIGVLAIEFFDVDGQLLVNEIAPRVHNSGHWTQQGTDVCQFEMHIRAVCNLPLVGAELIRSTAMINILGEDSLPKELLTM
PHCHIHWYGKEKRVGRKMGHINVCASSPEALEKELMALSELLDKNAFQVLSK
>Mature_372_residues
MMKVLVLGSGQLARMMSLASAPLNIDIIAYDVNNNKIVHPLTQQVMDTTLEQTINSVDVITAEFEHIPYDILDICSQSGK
FQPNPEAIKAGGDRRIEKTLLDNANVANATHHIITTKQEFLDSISSVGLPMVLKSALGGYDGKGQWRLKEASQIDHIWEE
MNELIQSTPNQAIVAEQFIPFNREVSLIGARNKNGDIVTYPLTENVHVNGVLALSTALEGTSLLQQQADDMFSAIVNELD
YIGVLAIEFFDVDGQLLVNEIAPRVHNSGHWTQQGTDVCQFEMHIRAVCNLPLVGAELIRSTAMINILGEDSLPKELLTM
PHCHIHWYGKEKRVGRKMGHINVCASSPEALEKELMALSELLDKNAFQVLSK

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=363, Percent_Identity=38.0165289256198, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1788155, Length=305, Percent_Identity=21.3114754098361, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324702, Length=380, Percent_Identity=30.5263157894737, Blast_Score=162, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41157; Mature: 41157

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKVLVLGSGQLARMMSLASAPLNIDIIAYDVNNNKIVHPLTQQVMDTTLEQTINSVDVI
CEEEEEECCCHHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCHHHEE
TAEFEHIPYDILDICSQSGKFQPNPEAIKAGGDRRIEKTLLDNANVANATHHIITTKQEF
EEHHHHCCHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCHHHEEECHHHH
LDSISSVGLPMVLKSALGGYDGKGQWRLKEASQIDHIWEEMNELIQSTPNQAIVAEQFIP
HHHHHHCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCC
FNREVSLIGARNKNGDIVTYPLTENVHVNGVLALSTALEGTSLLQQQADDMFSAIVNELD
CCCCEEEEECCCCCCCEEEECCCCCEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
YIGVLAIEFFDVDGQLLVNEIAPRVHNSGHWTQQGTDVCQFEMHIRAVCNLPLVGAELIR
HHEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
STAMINILGEDSLPKELLTMPHCHIHWYGKEKRVGRKMGHINVCASSPEALEKELMALSE
HHHEEEEECCCCCCHHHHCCCCEEEEEECCHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
LLDKNAFQVLSK
HHCCHHHHHHCC
>Mature Secondary Structure
MMKVLVLGSGQLARMMSLASAPLNIDIIAYDVNNNKIVHPLTQQVMDTTLEQTINSVDVI
CEEEEEECCCHHHHHHHHHCCCCEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCHHHEE
TAEFEHIPYDILDICSQSGKFQPNPEAIKAGGDRRIEKTLLDNANVANATHHIITTKQEF
EEHHHHCCHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCHHHEEECHHHH
LDSISSVGLPMVLKSALGGYDGKGQWRLKEASQIDHIWEEMNELIQSTPNQAIVAEQFIP
HHHHHHCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCC
FNREVSLIGARNKNGDIVTYPLTENVHVNGVLALSTALEGTSLLQQQADDMFSAIVNELD
CCCCEEEEECCCCCCCEEEECCCCCEEECEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
YIGVLAIEFFDVDGQLLVNEIAPRVHNSGHWTQQGTDVCQFEMHIRAVCNLPLVGAELIR
HHEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
STAMINILGEDSLPKELLTMPHCHIHWYGKEKRVGRKMGHINVCASSPEALEKELMALSE
HHHEEEEECCCCCCHHHHCCCCEEEEEECCHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
LLDKNAFQVLSK
HHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA