Click here to switch to the map view.

The map label for this gene is apt_1 [H]

Identifier: 209554084

GI number: 209554084

Start: 654391

End: 654912

Strand: Reverse

Name: apt_1 [H]

Synonym: UUR10_0545

Alternate gene names: 209554084

Gene position: 654912-654391 (Counterclockwise)

Preceding gene: 209554613

Following gene: 209554118

Centisome position: 74.89

GC content: 31.8

Gene sequence:

>522_bases
ATGATCAATATTGATTACATTAAATCAAAAATCAGGGATGTACCAGACTTCCCTAAAAAAGGAATCGTTTTTAAAGATAT
TACTCCTTTGTTTTTAGAACCAAAAATTATTGAAAAGATTGTTGATGATTTTGCTGACTTTGCTAAATCATTAAATATAG
ATGCTATAATAGGTGCGGAGTCGCGTGGTTTTTTATTTGCAGCACCATTATCAATCAAATTAAATAAGCCATTTATTTTG
GTACGTAAACCAAATAAGTTACCAAATGATGTTTATAGTGCTGAGTACACATTAGAATATGGTAGTTCTCGTGTGGAGAT
GCACAAAGATGCACTAAAACCAAACCAACGCGTTTTAATTGTCGATGATTTATTAGCAACAGGAGGGACTGTTGCTGCGA
TTGAAAATCTTGTTCATCAAGCTAAAGGAATTGTAGCAGGGAGTGTTTATTTGATTCGTTTAGGATTTCTAAAAGGTGAA
GAAAAACTAAGTGGAAAAGTTCATGCTTTAATTAATTATTAA

Upstream 100 bases:

>100_bases
TATTAGCTAAGGATGATAATGCAGATAATGTTTATGATAAATTTGATGAACAAGAAATTATGAATATAAATAAATTTTAA
AAGAAAGATTTATAACGATT

Downstream 100 bases:

>100_bases
TTTTTATAAAAATTAAATTCCTACTTTAAGAACCTACCAATGTTCTTAAAGTATTTTTTTTTTATATTATAATACTATAG
GAAATTTACACAATATAATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY

Sequences:

>Translated_173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY
>Mature_173_residues
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFIL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAKGIVAGSVYLIRLGFLKGE
EKLSGKVHALINY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=42.4242424242424, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=43.4108527131783, Blast_Score=113, Evalue=7e-26,
Organism=Escherichia coli, GI1786675, Length=161, Percent_Identity=43.4782608695652, Blast_Score=146, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=42.9411764705882, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=39.4117647058824, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=33.9181286549708, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19226; Mature: 19226

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCCEEEECCC
SRGFLFAAPLSIKLNKPFILVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVHQAKGIVAGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHCCCEECEEEEEEEECCCCCHHHCCEEEEEEEC
>Mature Secondary Structure
MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCCEEEECCC
SRGFLFAAPLSIKLNKPFILVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVHQAKGIVAGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHCCCEECEEEEEEEECCCCCHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA