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The map label for this gene is nhaK [H]

Identifier: 209550682

GI number: 209550682

Start: 3172633

End: 3174177

Strand: Direct

Name: nhaK [H]

Synonym: Rleg2_3106

Alternate gene names: 209550682

Gene position: 3172633-3174177 (Clockwise)

Preceding gene: 209550678

Following gene: 209550683

Centisome position: 69.91

GC content: 66.34

Gene sequence:

>1545_bases
ATGGCGTTCTTCGAAAGCATGCTGACGCTGCTGCTGGTGGCGATCGTCTTCCTGCAATTCTCCAGGAAATTCCGCATCCC
GTATCCGACCATGCTGGCGATCGCCGGCATCATCGTCGCCGCCGTGCCCTGGGCGCCCGAGGTCGCGATCGATCCTCAGC
TGGCACTGGCACTGCTGATTGCGCCGGTGCTTTTCGACGCCGCCTATGATCTGCCGCCGCGGACATTGCGACGCAACTGG
CTGCCGCTCTTCTCGCTCGCCGCCATCGCCGTGGTCCTGACAACAGCAGCCGTTGCCACCGTCGGCGTGACCATGGCCGG
CCTGCCGCTCGCTGCAGCCGTGGCACTCGGTGCCATTGTCGCGCCGCCGGATGCTGCGGCGGCGACCGCCATGCTCGACC
GCTTCGACCTGCCGCGCCAGACCTATGTGATCCTGAAAGGCGAGAGCCTTCTCAACGATGCCGTGGCGCTGCTGATCTTC
AGCGCCGCGGTGGCGGCCGCCGCAAGCCCCGCCTTCTTTACCGGCGCCCTGGCGGAGCTGGCGCTGGCGGTGCCGGGCGG
CCTCATCCTCGGCTATCTCCTCGGCCGTCTCTACATGGTGGTCGGGTTGAAGCTCGCCGGCACGCTCGGCGGCACCCTGC
TCGAATTCGTCGCCACCTTCGGCACCTGGATCATCGCCGAGCGGCTGCACCTTTCGGCGATCCTCGCCATCGTCGTCTAT
GCGATGGTGATCGCCCGCTACATGCCCGAGCGGCAGACGGCCCGCCACCGCATTCATTCCTATTCGGTCTGGGAAGCCGC
GGTCTTCCTGCTCAACGTGCTCGCCTTCCTGCTGATGGGCCTGCAAGTCCGCCAGATCGTCCTCGACCTCGATCCCGGCC
GGCTGAATTACGCAATCACCCTGGCCGCCGCGGTCTTCGTCACTGTCATCGGCGTGCGCCTGGCCTGGGTGCTCCTCTAT
AACCGCGTGATCACCTTCCTCGCCGAGCGCGGCTACACCAGACAGGCCGTTCCCACCTTCGCGACCAGCCTGCTTGCCGG
CTGGTGCGGCATGCGCGGCCTCGTGACGCTGGCGACTGCGCTGGCGCTGCCGATCGACTTCCCCGATCGCGACATCATTC
TCCTGAGTGCGCTGGCCGTCGTTCTCGGCACTCTCATCGTCCAGGGCCTGACGCTCGGGCCGCTGATCCGCGTCCTGAAA
TTCGAGCCGGACACCTCGCTCGACCGCAACCTCACCAGAGCCCGGGTCGCGTTGATCGATGCGGCGCTGGCCGAACTTGC
CGACGGCGAGGATAAATCCACCCGCATCCTGCGCGACGTCTACACCTCCGAGCGCGAGATCACCGCCGACGGGAAACATC
CACGCGAAGTCAGCAGCCTTGATAAGCAGCGCCGCAGCGTCATTGCCGCCAAACGCCGCAAACTGGCAGCGATGCGCCGC
GCCGACGAGATCGACGACGATGTCTTCCATATGCTGGAACAGGAGCTCGACTGGGCCGAACTCGCCGTCTTGCCGCCCGG
CCGCGACGAGATCGTCGAGAGCTGA

Upstream 100 bases:

>100_bases
TCTCTTGCGGGAGCAAGACTTCCGTCCAGTGGCCGCAACCCGGCTTCGGCCCTAGTTTCGGGCAGAGATCGCCTCCGCCG
GAGGTGCGCAGGAGGGCTCG

Downstream 100 bases:

>100_bases
CGCCATCCATGAAGTTTTGATGGATTTCGCAACCCCAGCCAATTGGCATTTGCTATTTTTCGCCGCTGCCGTTTATATCC
GGTTCTACAAGTTACGATTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MAFFESMLTLLLVAIVFLQFSRKFRIPYPTMLAIAGIIVAAVPWAPEVAIDPQLALALLIAPVLFDAAYDLPPRTLRRNW
LPLFSLAAIAVVLTTAAVATVGVTMAGLPLAAAVALGAIVAPPDAAAATAMLDRFDLPRQTYVILKGESLLNDAVALLIF
SAAVAAAASPAFFTGALAELALAVPGGLILGYLLGRLYMVVGLKLAGTLGGTLLEFVATFGTWIIAERLHLSAILAIVVY
AMVIARYMPERQTARHRIHSYSVWEAAVFLLNVLAFLLMGLQVRQIVLDLDPGRLNYAITLAAAVFVTVIGVRLAWVLLY
NRVITFLAERGYTRQAVPTFATSLLAGWCGMRGLVTLATALALPIDFPDRDIILLSALAVVLGTLIVQGLTLGPLIRVLK
FEPDTSLDRNLTRARVALIDAALAELADGEDKSTRILRDVYTSEREITADGKHPREVSSLDKQRRSVIAAKRRKLAAMRR
ADEIDDDVFHMLEQELDWAELAVLPPGRDEIVES

Sequences:

>Translated_514_residues
MAFFESMLTLLLVAIVFLQFSRKFRIPYPTMLAIAGIIVAAVPWAPEVAIDPQLALALLIAPVLFDAAYDLPPRTLRRNW
LPLFSLAAIAVVLTTAAVATVGVTMAGLPLAAAVALGAIVAPPDAAAATAMLDRFDLPRQTYVILKGESLLNDAVALLIF
SAAVAAAASPAFFTGALAELALAVPGGLILGYLLGRLYMVVGLKLAGTLGGTLLEFVATFGTWIIAERLHLSAILAIVVY
AMVIARYMPERQTARHRIHSYSVWEAAVFLLNVLAFLLMGLQVRQIVLDLDPGRLNYAITLAAAVFVTVIGVRLAWVLLY
NRVITFLAERGYTRQAVPTFATSLLAGWCGMRGLVTLATALALPIDFPDRDIILLSALAVVLGTLIVQGLTLGPLIRVLK
FEPDTSLDRNLTRARVALIDAALAELADGEDKSTRILRDVYTSEREITADGKHPREVSSLDKQRRSVIAAKRRKLAAMRR
ADEIDDDVFHMLEQELDWAELAVLPPGRDEIVES
>Mature_513_residues
AFFESMLTLLLVAIVFLQFSRKFRIPYPTMLAIAGIIVAAVPWAPEVAIDPQLALALLIAPVLFDAAYDLPPRTLRRNWL
PLFSLAAIAVVLTTAAVATVGVTMAGLPLAAAVALGAIVAPPDAAAATAMLDRFDLPRQTYVILKGESLLNDAVALLIFS
AAVAAAASPAFFTGALAELALAVPGGLILGYLLGRLYMVVGLKLAGTLGGTLLEFVATFGTWIIAERLHLSAILAIVVYA
MVIARYMPERQTARHRIHSYSVWEAAVFLLNVLAFLLMGLQVRQIVLDLDPGRLNYAITLAAAVFVTVIGVRLAWVLLYN
RVITFLAERGYTRQAVPTFATSLLAGWCGMRGLVTLATALALPIDFPDRDIILLSALAVVLGTLIVQGLTLGPLIRVLKF
EPDTSLDRNLTRARVALIDAALAELADGEDKSTRILRDVYTSEREITADGKHPREVSSLDKQRRSVIAAKRRKLAAMRRA
DEIDDDVFHMLEQELDWAELAVLPPGRDEIVES

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=431, Percent_Identity=22.969837587007, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI148727259, Length=475, Percent_Identity=21.8947368421053, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI41872703, Length=481, Percent_Identity=22.037422037422, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI14211919, Length=260, Percent_Identity=25.7692307692308, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI194239733, Length=383, Percent_Identity=24.8041775456919, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4759144, Length=387, Percent_Identity=24.031007751938, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI27734935, Length=415, Percent_Identity=22.6506024096386, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790501, Length=519, Percent_Identity=27.7456647398844, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71980847, Length=473, Percent_Identity=20.507399577167, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71999817, Length=387, Percent_Identity=21.9638242894057, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=407, Percent_Identity=21.8673218673219, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=381, Percent_Identity=22.3097112860892, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=492, Percent_Identity=21.3414634146341, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=492, Percent_Identity=21.3414634146341, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=404, Percent_Identity=20.7920792079208, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25150332, Length=396, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71990924, Length=404, Percent_Identity=20.7920792079208, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=252, Percent_Identity=23.4126984126984, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=252, Percent_Identity=23.4126984126984, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147678, Length=448, Percent_Identity=22.5446428571429, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987537, Length=378, Percent_Identity=22.2222222222222, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987535, Length=378, Percent_Identity=22.2222222222222, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=517, Percent_Identity=20.3094777562863, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281360447, Length=375, Percent_Identity=23.2, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221510734, Length=383, Percent_Identity=24.2819843342037, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221510738, Length=383, Percent_Identity=24.2819843342037, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55605; Mature: 55473

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFFESMLTLLLVAIVFLQFSRKFRIPYPTMLAIAGIIVAAVPWAPEVAIDPQLALALLI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
APVLFDAAYDLPPRTLRRNWLPLFSLAAIAVVLTTAAVATVGVTMAGLPLAAAVALGAIV
HHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPDAAAATAMLDRFDLPRQTYVILKGESLLNDAVALLIFSAAVAAAASPAFFTGALAEL
CCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALAVPGGLILGYLLGRLYMVVGLKLAGTLGGTLLEFVATFGTWIIAERLHLSAILAIVVY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVIARYMPERQTARHRIHSYSVWEAAVFLLNVLAFLLMGLQVRQIVLDLDPGRLNYAIT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAAAVFVTVIGVRLAWVLLYNRVITFLAERGYTRQAVPTFATSLLAGWCGMRGLVTLATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LALPIDFPDRDIILLSALAVVLGTLIVQGLTLGPLIRVLKFEPDTSLDRNLTRARVALID
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AALAELADGEDKSTRILRDVYTSEREITADGKHPREVSSLDKQRRSVIAAKRRKLAAMRR
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEIDDDVFHMLEQELDWAELAVLPPGRDEIVES
HHCCCHHHHHHHHHCCCHHHEEECCCCHHHHCCC
>Mature Secondary Structure 
AFFESMLTLLLVAIVFLQFSRKFRIPYPTMLAIAGIIVAAVPWAPEVAIDPQLALALLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
APVLFDAAYDLPPRTLRRNWLPLFSLAAIAVVLTTAAVATVGVTMAGLPLAAAVALGAIV
HHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPDAAAATAMLDRFDLPRQTYVILKGESLLNDAVALLIFSAAVAAAASPAFFTGALAEL
CCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALAVPGGLILGYLLGRLYMVVGLKLAGTLGGTLLEFVATFGTWIIAERLHLSAILAIVVY
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVIARYMPERQTARHRIHSYSVWEAAVFLLNVLAFLLMGLQVRQIVLDLDPGRLNYAIT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAAAVFVTVIGVRLAWVLLYNRVITFLAERGYTRQAVPTFATSLLAGWCGMRGLVTLATA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LALPIDFPDRDIILLSALAVVLGTLIVQGLTLGPLIRVLKFEPDTSLDRNLTRARVALID
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AALAELADGEDKSTRILRDVYTSEREITADGKHPREVSSLDKQRRSVIAAKRRKLAAMRR
HHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADEIDDDVFHMLEQELDWAELAVLPPGRDEIVES
HHCCCHHHHHHHHHCCCHHHEEECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA