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The map label for this gene is yeiA [H]

Identifier: 209550605

GI number: 209550605

Start: 3088014

End: 3089327

Strand: Direct

Name: yeiA [H]

Synonym: Rleg2_3029

Alternate gene names: 209550605

Gene position: 3088014-3089327 (Clockwise)

Preceding gene: 209550604

Following gene: 209550606

Centisome position: 68.05

GC content: 63.62

Gene sequence:

>1314_bases
ATGGCTGATCTCCGCAATAATTTCGTCGGCATCAAGTCCCCGAACCCGTTCTGGCTGGCCTCTGCGCCGCCGACCGACAA
GGCCTACAACGTCGAGCGCGCCTTCAAGGCCGGCTGGGGCGGCGTGGTCTGGAAGACGCTCGGCGAGGAAGGCCCGCCCG
TCGTCAACGTCAACGGCCCGCGCTACGGCGCGATCTTCGGCGCAGACCGCCGCCTGCTCGGCCTAAACAATATCGAGCTC
ATCACCGACCGCGACCTCTACACCAATCTCAGGGAAATGAAGCAGGTCAAGATGAACTGGCCGGATCGGGCGCTGATCGC
CTCGATCATGGTGCCCTGCGAGGAACAGGCCTGGAAGTCCATCCTGCCACTCGTCGAAGAGACCGGCGCCGACGGAGTCG
AACTGAATTTCGGCTGTCCGCACGGCATGTCGGAGCGAGGGATGGGCTCAGCCGTCGGCCAGGTGCCGGAATATATCGAA
ATGGTCGTGCGCTGGTGCAAGCAATACACCCGTATGCCCATCATCACCAAGCTGACGCCCAACATCACCGACGTTCGCCG
TCCTGCCCGCGCCGCCAAGGCCGGGGGCACCGATGCCGTCTCGCTGATCAACACGATCAATTCGATCGTATCCGTCGATC
TCGACAACTTCGCCCCCAACCCGACGGTCGGCGGCAAGGGCAGCCATGGCGGCTATTGCGGCCCGGCGGTCAAGCCGATC
GCCCTCAACATGGTGGCCGAGATCGCCCGAGATCCCGAAACCTACGGCCTGCCGATCTCCGGCATCGGCGGCATCACCAC
CTGGCGAGACGCGGCTGAATTCCTCGTTCTCGGCGCCGGCAACGTCCAGGTCTGCACGGCCGCGATGACCTACGGCTTCA
AGATCGTGCAGGAGATGATTTCCGGCCTTTCCGACTGGATGGACGAAAAAGGCCATCGCAGCCTCGACGATATCACCGGC
CGCGCCGTGCCCAACGTCACCGACTGGCAGTATCTGAACCTCAACTACATCGCCAAGGCAAAGATCGACCAGGATGCCTG
CATCAAATGCGGCCGCTGCCACATCGCCTGCGAGGACACCTCGCATCAGGCGATCACCAACGTCGTCAACGGCCTGCGCC
ATTTCGAGGTGATCGAGGAGGAATGCGTCGGCTGCAATCTCTGCGTCAACGTCTGCCCGGTCGAGAACTGCATCACCATG
GAGCCGCTTGCCGCCGGCACCCTCGACAAGCGCACCGGCCGCACCGTCGACCCGAACTACGCCAACTGGACGACGCACCC
GAACAACCCGATGGCCCGCCAGGCGGCGGAGTGA

Upstream 100 bases:

>100_bases
CGCCGTCGCTCACGGCCGCGACGCGGCTGAATCCATCCATCGCACCCTCACCGCAGCCGCCGCTCCGGCTGTCGCGGTTG
CTTGAAGGGGAGAATGAATC

Downstream 100 bases:

>100_bases
AAACTTCATTTGATTGAGCGATCCCCCGGCAACGGGGGATTTTGTTTGCGCGTGGATCAGATTAGGGTCGACCGAAAGCA
AGCTGTGGCATGAAAATGGT

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIFGADRRLLGLNNIEL
ITDRDLYTNLREMKQVKMNWPDRALIASIMVPCEEQAWKSILPLVEETGADGVELNFGCPHGMSERGMGSAVGQVPEYIE
MVVRWCKQYTRMPIITKLTPNITDVRRPARAAKAGGTDAVSLINTINSIVSVDLDNFAPNPTVGGKGSHGGYCGPAVKPI
ALNMVAEIARDPETYGLPISGIGGITTWRDAAEFLVLGAGNVQVCTAAMTYGFKIVQEMISGLSDWMDEKGHRSLDDITG
RAVPNVTDWQYLNLNYIAKAKIDQDACIKCGRCHIACEDTSHQAITNVVNGLRHFEVIEEECVGCNLCVNVCPVENCITM
EPLAAGTLDKRTGRTVDPNYANWTTHPNNPMARQAAE

Sequences:

>Translated_437_residues
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIFGADRRLLGLNNIEL
ITDRDLYTNLREMKQVKMNWPDRALIASIMVPCEEQAWKSILPLVEETGADGVELNFGCPHGMSERGMGSAVGQVPEYIE
MVVRWCKQYTRMPIITKLTPNITDVRRPARAAKAGGTDAVSLINTINSIVSVDLDNFAPNPTVGGKGSHGGYCGPAVKPI
ALNMVAEIARDPETYGLPISGIGGITTWRDAAEFLVLGAGNVQVCTAAMTYGFKIVQEMISGLSDWMDEKGHRSLDDITG
RAVPNVTDWQYLNLNYIAKAKIDQDACIKCGRCHIACEDTSHQAITNVVNGLRHFEVIEEECVGCNLCVNVCPVENCITM
EPLAAGTLDKRTGRTVDPNYANWTTHPNNPMARQAAE
>Mature_436_residues
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGPRYGAIFGADRRLLGLNNIELI
TDRDLYTNLREMKQVKMNWPDRALIASIMVPCEEQAWKSILPLVEETGADGVELNFGCPHGMSERGMGSAVGQVPEYIEM
VVRWCKQYTRMPIITKLTPNITDVRRPARAAKAGGTDAVSLINTINSIVSVDLDNFAPNPTVGGKGSHGGYCGPAVKPIA
LNMVAEIARDPETYGLPISGIGGITTWRDAAEFLVLGAGNVQVCTAAMTYGFKIVQEMISGLSDWMDEKGHRSLDDITGR
AVPNVTDWQYLNLNYIAKAKIDQDACIKCGRCHIACEDTSHQAITNVVNGLRHFEVIEEECVGCNLCVNVCPVENCITME
PLAAGTLDKRTGRTVDPNYANWTTHPNNPMARQAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=334, Percent_Identity=36.5269461077844, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI87082059, Length=398, Percent_Identity=43.7185929648241, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI71984108, Length=329, Percent_Identity=37.6899696048632, Blast_Score=214, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6322633, Length=329, Percent_Identity=27.355623100304, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640763, Length=317, Percent_Identity=38.4858044164038, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI18858217, Length=317, Percent_Identity=38.4858044164038, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47651; Mature: 47520

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCCEEECCCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIFGADRRLLGLNNIELITDRDLYTNLREMKQVKMNWPDRALIASIMVPCEEQAWKS
CEEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
ILPLVEETGADGVELNFGCPHGMSERGMGSAVGQVPEYIEMVVRWCKQYTRMPIITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDVRRPARAAKAGGTDAVSLINTINSIVSVDLDNFAPNPTVGGKGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECHHCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDPETYGLPISGIGGITTWRDAAEFLVLGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCEEHHHHHHHHHHHHHHHH
SGLSDWMDEKGHRSLDDITGRAVPNVTDWQYLNLNYIAKAKIDQDACIKCGRCHIACEDT
HHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCEEEEEECCCHHHHHCCCCEEEEECCC
SHQAITNVVNGLRHFEVIEEECVGCNLCVNVCPVENCITMEPLAAGTLDKRTGRTVDPNY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHCCCCCCCCCCCCCCCC
ANWTTHPNNPMARQAAE
CCCCCCCCCCCHHCCCC
>Mature Secondary Structure 
ADLRNNFVGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGEEGPPVVNVNGP
CCCCCCEEECCCCCCEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCCCCEEEECCC
RYGAIFGADRRLLGLNNIELITDRDLYTNLREMKQVKMNWPDRALIASIMVPCEEQAWKS
CEEEEECCCCEEECCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
ILPLVEETGADGVELNFGCPHGMSERGMGSAVGQVPEYIEMVVRWCKQYTRMPIITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NITDVRRPARAAKAGGTDAVSLINTINSIVSVDLDNFAPNPTVGGKGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECHHCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDPETYGLPISGIGGITTWRDAAEFLVLGAGNVQVCTAAMTYGFKIVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCEEHHHHHHHHHHHHHHHH
SGLSDWMDEKGHRSLDDITGRAVPNVTDWQYLNLNYIAKAKIDQDACIKCGRCHIACEDT
HHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCEEEEEECCCHHHHHCCCCEEEEECCC
SHQAITNVVNGLRHFEVIEEECVGCNLCVNVCPVENCITMEPLAAGTLDKRTGRTVDPNY
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCHHCCCCCCCCCCCCCCCC
ANWTTHPNNPMARQAAE
CCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]