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The map label for this gene is yciC [H]

Identifier: 209549969

GI number: 209549969

Start: 2446411

End: 2447616

Strand: Direct

Name: yciC [H]

Synonym: Rleg2_2385

Alternate gene names: 209549969

Gene position: 2446411-2447616 (Clockwise)

Preceding gene: 209549968

Following gene: 209549971

Centisome position: 53.91

GC content: 63.6

Gene sequence:

>1206_bases
ATGGACAACAGACTTCCGGTCACGGTGCTCTCCGGCTTTCTCGGCGCCGGCAAGACGACGCTGCTGAACCACGTGCTTGC
CAATCGCGAAGGCATGCGCGTCGCCGTCATCGTCAACGACATGAGCGAGGTGAATATCGACGCCGCCCTGGTGCGCGATG
GCGGCGCCAATCTGTCTCGCACCGAGGAGCAGCTGGTCGAGATGACCAATGGCTGCATCTGCTGCACCCTGCGCGACGAC
CTCTTGAAGGAGGTGCGCGATCTGGCGACCCAAGGCCGCTTCGATTACCTGCTGATCGAATCCACGGGCATCGCCGAGCC
CCTGCCCGTCGCCACCACCTTCGAATTCCGCGATGAAAACGGAGAAAGCCTTTCCGACCTCGCAAGACTGGATACGATGG
TGACCGTCGTCGATGCCGCCAATCTGCTTACCGACTATGCCTCGGCCGATTTCCTCGCCGACCGCGGCGAAACGGCAGGC
GATGGCGATACCAGAACCATCGTCGACCTGCTGGTCGAGCAGATCGAATTCGCCGATGTCGTGGTGCTGAACAAGATCGG
CACGGCAAGCGAGACGGAACGCGACGCCGCGCGGAAAATCATCACCGGCCTCAACCCGGATGCGAAGCTGATCGAAGCGG
ATTTCGGCAAGGTGGGGCTGAAGGAGGTGCTCGGCACCGGCCGCTTCGATATATCAAGGGCCGAGACCCACCCGCTCTGG
TACAAGGAGCTGCATGGCTTCAAGGACCATGTGCCGGAGACCGAGGAATATGGCATCCGCTCCTTCGTCTACCGCGAGAA
GCGACCCTTTCATCCGGCAAAATTGCAGGCCTTCCTCGACCTGACATGGCCGGGCGTGGTGCGCGCCAAAGGCTTCTTCT
GGCTGGCGACGCGGCCGCACCATGTCGGCGAGATCAGCCAGGCGGGCGCCCTCGTGCGCACCGGCAAGATGGGCCTCTGG
TGGGCGGCGGTGCCGCGCGAACAATGGCCCGACGAACCGGGCTTCATCAATGCCATCGGCCCCTATCTCGACCCCGTCTG
GGGCGATCGCCGCCAGGAAATCGTCTTCATCGGCGCCGACCCGATGGACGAGGCCTGGATCAGGAGAGAACTCGACGCCT
GCCTCATCGAGACCGCGGTCTTCACGCCCGATCGCTGGCGAAACCTGCCCGACCCCTTCGCCAGCTGGAACCGCCAGGCG
GCATGA

Upstream 100 bases:

>100_bases
GCGCTCCGGGGAGAGCTGAGGCGGAAAGAGGCGGATGACCCCGTTCCGCCTTTTTTCGGCTCGATCAATGTAATGATATA
ACATTGATATGTGAGGTTTC

Downstream 100 bases:

>100_bases
CGGCAACGGCGATCAAACCCTATCGCTGCGTTTGCACGGAGTGTGATCGGCTGCCGCCGATCGAGGGGCTGCATCCGTTG
GCACATGACGGGGATGTGAA

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDNRLPVTVLSGFLGAGKTTLLNHVLANREGMRVAVIVNDMSEVNIDAALVRDGGANLSRTEEQLVEMTNGCICCTLRDD
LLKEVRDLATQGRFDYLLIESTGIAEPLPVATTFEFRDENGESLSDLARLDTMVTVVDAANLLTDYASADFLADRGETAG
DGDTRTIVDLLVEQIEFADVVVLNKIGTASETERDAARKIITGLNPDAKLIEADFGKVGLKEVLGTGRFDISRAETHPLW
YKELHGFKDHVPETEEYGIRSFVYREKRPFHPAKLQAFLDLTWPGVVRAKGFFWLATRPHHVGEISQAGALVRTGKMGLW
WAAVPREQWPDEPGFINAIGPYLDPVWGDRRQEIVFIGADPMDEAWIRRELDACLIETAVFTPDRWRNLPDPFASWNRQA
A

Sequences:

>Translated_401_residues
MDNRLPVTVLSGFLGAGKTTLLNHVLANREGMRVAVIVNDMSEVNIDAALVRDGGANLSRTEEQLVEMTNGCICCTLRDD
LLKEVRDLATQGRFDYLLIESTGIAEPLPVATTFEFRDENGESLSDLARLDTMVTVVDAANLLTDYASADFLADRGETAG
DGDTRTIVDLLVEQIEFADVVVLNKIGTASETERDAARKIITGLNPDAKLIEADFGKVGLKEVLGTGRFDISRAETHPLW
YKELHGFKDHVPETEEYGIRSFVYREKRPFHPAKLQAFLDLTWPGVVRAKGFFWLATRPHHVGEISQAGALVRTGKMGLW
WAAVPREQWPDEPGFINAIGPYLDPVWGDRRQEIVFIGADPMDEAWIRRELDACLIETAVFTPDRWRNLPDPFASWNRQA
A
>Mature_401_residues
MDNRLPVTVLSGFLGAGKTTLLNHVLANREGMRVAVIVNDMSEVNIDAALVRDGGANLSRTEEQLVEMTNGCICCTLRDD
LLKEVRDLATQGRFDYLLIESTGIAEPLPVATTFEFRDENGESLSDLARLDTMVTVVDAANLLTDYASADFLADRGETAG
DGDTRTIVDLLVEQIEFADVVVLNKIGTASETERDAARKIITGLNPDAKLIEADFGKVGLKEVLGTGRFDISRAETHPLW
YKELHGFKDHVPETEEYGIRSFVYREKRPFHPAKLQAFLDLTWPGVVRAKGFFWLATRPHHVGEISQAGALVRTGKMGLW
WAAVPREQWPDEPGFINAIGPYLDPVWGDRRQEIVFIGADPMDEAWIRRELDACLIETAVFTPDRWRNLPDPFASWNRQA
A

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=293, Percent_Identity=31.3993174061433, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI126722884, Length=293, Percent_Identity=31.3993174061433, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI148727351, Length=293, Percent_Identity=31.0580204778157, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI146231952, Length=262, Percent_Identity=32.0610687022901, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI223941779, Length=236, Percent_Identity=32.6271186440678, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI223941776, Length=251, Percent_Identity=32.2709163346614, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI119120938, Length=138, Percent_Identity=39.8550724637681, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082430, Length=311, Percent_Identity=28.2958199356913, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788499, Length=213, Percent_Identity=27.2300469483568, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=193, Percent_Identity=30.0518134715026, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44711; Mature: 44711

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRLPVTVLSGFLGAGKTTLLNHVLANREGMRVAVIVNDMSEVNIDAALVRDGGANLSR
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCCHH
TEEQLVEMTNGCICCTLRDDLLKEVRDLATQGRFDYLLIESTGIAEPLPVATTFEFRDEN
HHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GESLSDLARLDTMVTVVDAANLLTDYASADFLADRGETAGDGDTRTIVDLLVEQIEFADV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHE
VVLNKIGTASETERDAARKIITGLNPDAKLIEADFGKVGLKEVLGTGRFDISRAETHPLW
EEEECCCCCCHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHHHHCCCCCCCCCCCCCCHH
YKELHGFKDHVPETEEYGIRSFVYREKRPFHPAKLQAFLDLTWPGVVRAKGFFWLATRPH
HHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCEEEEECCCC
HVGEISQAGALVRTGKMGLWWAAVPREQWPDEPGFINAIGPYLDPVWGDRRQEIVFIGAD
CCCCHHHCCCEEEECCCCEEEEECCHHHCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCC
PMDEAWIRRELDACLIETAVFTPDRWRNLPDPFASWNRQAA
CCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCCCC
>Mature Secondary Structure
MDNRLPVTVLSGFLGAGKTTLLNHVLANREGMRVAVIVNDMSEVNIDAALVRDGGANLSR
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEECCCCCCHH
TEEQLVEMTNGCICCTLRDDLLKEVRDLATQGRFDYLLIESTGIAEPLPVATTFEFRDEN
HHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GESLSDLARLDTMVTVVDAANLLTDYASADFLADRGETAGDGDTRTIVDLLVEQIEFADV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHE
VVLNKIGTASETERDAARKIITGLNPDAKLIEADFGKVGLKEVLGTGRFDISRAETHPLW
EEEECCCCCCHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHHHHCCCCCCCCCCCCCCHH
YKELHGFKDHVPETEEYGIRSFVYREKRPFHPAKLQAFLDLTWPGVVRAKGFFWLATRPH
HHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEECCEEEEECCCC
HVGEISQAGALVRTGKMGLWWAAVPREQWPDEPGFINAIGPYLDPVWGDRRQEIVFIGAD
CCCCHHHCCCEEEECCCCEEEEECCHHHCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCC
PMDEAWIRRELDACLIETAVFTPDRWRNLPDPFASWNRQAA
CCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]