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The map label for this gene is znuA [H]

Identifier: 209549968

GI number: 209549968

Start: 2445248

End: 2446303

Strand: Direct

Name: znuA [H]

Synonym: Rleg2_2384

Alternate gene names: 209549968

Gene position: 2445248-2446303 (Clockwise)

Preceding gene: 209549964

Following gene: 209549969

Centisome position: 53.88

GC content: 64.02

Gene sequence:

>1056_bases
ATGAAACGCACCCTGGGCCCAGCCCTGAAGATCCTGGCCTTTAAAATTCCGCTCGCCCTCGCCCTACCGGCGCTGGCGGT
CCCCGCCTTGCTGTTTGCCGGCACCATGCGGGCCGCCGACGCGCCTGTGGTCGTCACCTCGATCAAGCCGATCCATTCGC
TGGTTGCGGCGATCATGCAGGGTGTGGGCGAACCGGAGCTGATCGTCGATGGCGCCGCCTCCCCGCATACTTATAGCCTG
AAGCCGTCGAATGCGCGCGCGCTGCAGGAAGCCAAGGTGATCTTCTGGACCGGCCCCGGCCTCGAGACTTTCCTGGAAAA
ACCGCTGCAGGCGCTGGGCTCGAAGGCCAGCATCGCCGAGCTCGATCATGCCCCCGGCCTCGTCAAGCTGCCCTTCCGCG
AAGGCGGCGCCTTCGAGCCACATGAGGATGGCGATGAGCACCATGGCGCTTCCGCCGAGGGTGAGGATCACGATCATGCA
GCCGGCACCGGGCATGATGACCATGATCACGGACATGACGGTGACCATGACCATGGCGCCTTCGACACGCATCTCTGGCT
CGACCCGATGAATGCCAAAGCCATGGCCGCCGTGATCACCACGACGCTGGTCGCCGCCGATCCCGCCAATGCGCTGACCT
ACCAGGCCAATGCCAAGGCGCTGGACGACAAGCTGACGGCGCTGGATAAGGAAATCGCCGCCACCGTTGCTCCCGTCAAG
GACAAGCCCTTCATCGTCTTCCACGACGCCTACCAGTACTTCGAGCATCGCTACGGCATCCGCGTCGCCGGCTCGATCAC
CGTCAGCCCGGAAACCATTCCCGGTGCCGAGCGTGTTTCGGAAATCCACCGCAAAGTCGGCGAACTCGGCGCCACCTGCG
TCTTTGCCGAACCGCAATTCGAGCCGCGCCTCGTCAATGTCGTCATCGAAGGCACGAAGGCCAGATCCGGCGTGCTCGAC
CCCGAAGCGGCAACGCTGAAGGCCGGCCCCGATCTCTACTTCACCCTCATGCGCGGCATCGCCGAGAGCATGAAGGATTG
CCTCTCCAACGCATGA

Upstream 100 bases:

>100_bases
AAATTTTCCGACAGCGCTGTTGCATCCTGCTATTGCACACGTTATAGCATAACGCAATTGATGTAATAACATAACATCTG
CAATTCAAGCGGAGCATTCG

Downstream 100 bases:

>100_bases
TTGTCATGCGCTCCGGGGAGAGCTGAGGCGGAAAGAGGCGGATGACCCCGTTCCGCCTTTTTTCGGCTCGATCAATGTAA
TGATATAACATTGATATGTG

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKRTLGPALKILAFKIPLALALPALAVPALLFAGTMRAADAPVVVTSIKPIHSLVAAIMQGVGEPELIVDGAASPHTYSL
KPSNARALQEAKVIFWTGPGLETFLEKPLQALGSKASIAELDHAPGLVKLPFREGGAFEPHEDGDEHHGASAEGEDHDHA
AGTGHDDHDHGHDGDHDHGAFDTHLWLDPMNAKAMAAVITTTLVAADPANALTYQANAKALDDKLTALDKEIAATVAPVK
DKPFIVFHDAYQYFEHRYGIRVAGSITVSPETIPGAERVSEIHRKVGELGATCVFAEPQFEPRLVNVVIEGTKARSGVLD
PEAATLKAGPDLYFTLMRGIAESMKDCLSNA

Sequences:

>Translated_351_residues
MKRTLGPALKILAFKIPLALALPALAVPALLFAGTMRAADAPVVVTSIKPIHSLVAAIMQGVGEPELIVDGAASPHTYSL
KPSNARALQEAKVIFWTGPGLETFLEKPLQALGSKASIAELDHAPGLVKLPFREGGAFEPHEDGDEHHGASAEGEDHDHA
AGTGHDDHDHGHDGDHDHGAFDTHLWLDPMNAKAMAAVITTTLVAADPANALTYQANAKALDDKLTALDKEIAATVAPVK
DKPFIVFHDAYQYFEHRYGIRVAGSITVSPETIPGAERVSEIHRKVGELGATCVFAEPQFEPRLVNVVIEGTKARSGVLD
PEAATLKAGPDLYFTLMRGIAESMKDCLSNA
>Mature_351_residues
MKRTLGPALKILAFKIPLALALPALAVPALLFAGTMRAADAPVVVTSIKPIHSLVAAIMQGVGEPELIVDGAASPHTYSL
KPSNARALQEAKVIFWTGPGLETFLEKPLQALGSKASIAELDHAPGLVKLPFREGGAFEPHEDGDEHHGASAEGEDHDHA
AGTGHDDHDHGHDGDHDHGAFDTHLWLDPMNAKAMAAVITTTLVAADPANALTYQANAKALDDKLTALDKEIAATVAPVK
DKPFIVFHDAYQYFEHRYGIRVAGSITVSPETIPGAERVSEIHRKVGELGATCVFAEPQFEPRLVNVVIEGTKARSGVLD
PEAATLKAGPDLYFTLMRGIAESMKDCLSNA

Specific function: Involved in the high-affinity zinc uptake transport system. Required for survival and normal growth under low Zn (2+) concentrations. Also required for virulence and intracellular growth in macrophages [H]

COG id: COG4531

COG function: function code P; ABC-type Zn2+ transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=320, Percent_Identity=36.875, Blast_Score=202, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 37274; Mature: 37274

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTLGPALKILAFKIPLALALPALAVPALLFAGTMRAADAPVVVTSIKPIHSLVAAIMQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
GVGEPELIVDGAASPHTYSLKPSNARALQEAKVIFWTGPGLETFLEKPLQALGSKASIAE
CCCCCCEEEECCCCCCEEEECCCCHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCHHH
LDHAPGLVKLPFREGGAFEPHEDGDEHHGASAEGEDHDHAAGTGHDDHDHGHDGDHDHGA
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FDTHLWLDPMNAKAMAAVITTTLVAADPANALTYQANAKALDDKLTALDKEIAATVAPVK
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
DKPFIVFHDAYQYFEHRYGIRVAGSITVSPETIPGAERVSEIHRKVGELGATCVFAEPQF
CCCEEEEHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCC
EPRLVNVVIEGTKARSGVLDPEAATLKAGPDLYFTLMRGIAESMKDCLSNA
CCEEEEEEEECCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRTLGPALKILAFKIPLALALPALAVPALLFAGTMRAADAPVVVTSIKPIHSLVAAIMQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
GVGEPELIVDGAASPHTYSLKPSNARALQEAKVIFWTGPGLETFLEKPLQALGSKASIAE
CCCCCCEEEECCCCCCEEEECCCCHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCHHH
LDHAPGLVKLPFREGGAFEPHEDGDEHHGASAEGEDHDHAAGTGHDDHDHGHDGDHDHGA
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FDTHLWLDPMNAKAMAAVITTTLVAADPANALTYQANAKALDDKLTALDKEIAATVAPVK
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCC
DKPFIVFHDAYQYFEHRYGIRVAGSITVSPETIPGAERVSEIHRKVGELGATCVFAEPQF
CCCEEEEHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCC
EPRLVNVVIEGTKARSGVLDPEAATLKAGPDLYFTLMRGIAESMKDCLSNA
CCEEEEEEEECCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA