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The map label for this gene is fabF [H]

Identifier: 209549351

GI number: 209549351

Start: 1795906

End: 1797171

Strand: Reverse

Name: fabF [H]

Synonym: Rleg2_1755

Alternate gene names: 209549351

Gene position: 1797171-1795906 (Counterclockwise)

Preceding gene: 209549352

Following gene: 209549350

Centisome position: 39.6

GC content: 68.33

Gene sequence:

>1266_bases
ATGGATCGCATCGTCGTCACCGGCATGGGACTTGTCTCGCCGCTCGGCACCGGCGTCGAGCTCGCCTGGAGGCGCCTTCT
TGACGGCGGTTCGGGGCTGAGGCTGCTTTCGGACGATGTCGTCGGCGAGCTGCCGGCCAAGGTCGGCGGCATCGTTCCTG
ATGTCACCAAGGATGTGGAGGCCGGTTTCGATCCCGACCGTTACATCACGCCCAAGGACCAGAAGAAGATGGACCGCTTC
ATCCAGTTCGCCATGGCGGCGACGGAGGAAGCGGTGAAGCAGGCCGGCTGGATGCCGACCGACGAAGCGAAACGCGAGCG
CACCGCAACGATCATCGCCTCCGGGGTCGGCGGTTTTCCGGCGATCGCCGAGGCGGTGCGGATCGGCGAAACGCGCGGCG
TGCGGCGGCTGTCGCCCTTCACCGTGCCCTCCTTCCTCGTCAATCTCGCCGCCGGTCAGGTCAGCATCCGTTACGGCTTC
AGGGGGCCGCTCGGCGCGCCGGTGACGGCTTGTGCGGCCAGCGTCCAGGCGATCGGCGACGCGGCGCGGCTGATCCGTTC
CGGCGAAGCGGATGTGGCGATCTGCGGCGGCGCCGAGGCCTGCATCGACAAGGTGAGCCTCGGCGGCTTTGCTGCTGCGC
GTGCGCTTTCCACCGGCTTCAACGAGACGCCGGAGCTGGCCTCGCGGCCCTTCGACACGGCGCGCGACGGTTTCGTCATG
GGCGAAGGCGCCGGCATTCTGGTCATCGAAACACTGGAGCATGCGCTTGCCCGCGGGGCGACGCCGCTGGCCGAACTCGT
CGGCTACGGCACGGCGGCGGATGCCTACCATATGACCTCAGGCCCCGAAGACGGCGACGGCGCGCGCCGGGCAATGGAAG
CAGCCCTCCGGCAAGCGAACATCCCGGCATCCGAGGTCAAGCACCTTAACGCGCATGCGACCTCCACACCGGTCGGTGAC
AGAGGCGAGATCGCGGCGGTCGCCACGGTCTTCGGCCGCAATGGCGGCATTGCCGTCAGTGCGACGAAATCGGCGACCGG
CCATCTGCTGGGTGCTGCCGGCGGGCTGGAGGCGATCTTCACCATCCTGGCGTTGCGCGACCAGATCGCGCCGCCGACCC
GCAACCTGGATCAGGCCGATGCCGCCGCCGATGGGATCGATATCGTCGGCAAGACGGCGCGGTCGCTGCCCATGGACTAC
GCCATCACCAACGGTTTCGGCTTCGGCGGCGTCAATGCCAGCGCGCTCTTCCGCCGCTGGTCGTAA

Upstream 100 bases:

>100_bases
AGCCTGCTTGCAGGCCCCGCCGCCGATGACGCGGTGCACGAGCGGATCGCCCGCATGCGCGCCTGGTATCTCGGCATCGA
CGCATAGAGAGGAAAATATC

Downstream 100 bases:

>100_bases
AGTCCGCTTTTCTTAAGTAAAAAATCGCCTACACTTCTATTCTATCGGGGATCATTCTCCGATAGAGCTGGAGATCCCCC
ATGCGCGCCTTCTTCGCAGT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDRIVVTGMGLVSPLGTGVELAWRRLLDGGSGLRLLSDDVVGELPAKVGGIVPDVTKDVEAGFDPDRYITPKDQKKMDRF
IQFAMAATEEAVKQAGWMPTDEAKRERTATIIASGVGGFPAIAEAVRIGETRGVRRLSPFTVPSFLVNLAAGQVSIRYGF
RGPLGAPVTACAASVQAIGDAARLIRSGEADVAICGGAEACIDKVSLGGFAAARALSTGFNETPELASRPFDTARDGFVM
GEGAGILVIETLEHALARGATPLAELVGYGTAADAYHMTSGPEDGDGARRAMEAALRQANIPASEVKHLNAHATSTPVGD
RGEIAAVATVFGRNGGIAVSATKSATGHLLGAAGGLEAIFTILALRDQIAPPTRNLDQADAAADGIDIVGKTARSLPMDY
AITNGFGFGGVNASALFRRWS

Sequences:

>Translated_421_residues
MDRIVVTGMGLVSPLGTGVELAWRRLLDGGSGLRLLSDDVVGELPAKVGGIVPDVTKDVEAGFDPDRYITPKDQKKMDRF
IQFAMAATEEAVKQAGWMPTDEAKRERTATIIASGVGGFPAIAEAVRIGETRGVRRLSPFTVPSFLVNLAAGQVSIRYGF
RGPLGAPVTACAASVQAIGDAARLIRSGEADVAICGGAEACIDKVSLGGFAAARALSTGFNETPELASRPFDTARDGFVM
GEGAGILVIETLEHALARGATPLAELVGYGTAADAYHMTSGPEDGDGARRAMEAALRQANIPASEVKHLNAHATSTPVGD
RGEIAAVATVFGRNGGIAVSATKSATGHLLGAAGGLEAIFTILALRDQIAPPTRNLDQADAAADGIDIVGKTARSLPMDY
AITNGFGFGGVNASALFRRWS
>Mature_421_residues
MDRIVVTGMGLVSPLGTGVELAWRRLLDGGSGLRLLSDDVVGELPAKVGGIVPDVTKDVEAGFDPDRYITPKDQKKMDRF
IQFAMAATEEAVKQAGWMPTDEAKRERTATIIASGVGGFPAIAEAVRIGETRGVRRLSPFTVPSFLVNLAAGQVSIRYGF
RGPLGAPVTACAASVQAIGDAARLIRSGEADVAICGGAEACIDKVSLGGFAAARALSTGFNETPELASRPFDTARDGFVM
GEGAGILVIETLEHALARGATPLAELVGYGTAADAYHMTSGPEDGDGARRAMEAALRQANIPASEVKHLNAHATSTPVGD
RGEIAAVATVFGRNGGIAVSATKSATGHLLGAAGGLEAIFTILALRDQIAPPTRNLDQADAAADGIDIVGKTARSLPMDY
AITNGFGFGGVNASALFRRWS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=45.4545454545455, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI223972627, Length=190, Percent_Identity=40.5263157894737, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=26.027397260274, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=48.6873508353222, Blast_Score=342, Evalue=3e-95,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=36.1702127659575, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=426, Percent_Identity=38.7323943661972, Blast_Score=256, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=40.9774436090226, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI212642053, Length=436, Percent_Identity=26.8348623853211, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=365, Percent_Identity=23.8356164383562, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=37.9464285714286, Blast_Score=294, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=44.578313253012, Blast_Score=327, Evalue=7e-90,
Organism=Drosophila melanogaster, GI19920632, Length=434, Percent_Identity=23.7327188940092, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=434, Percent_Identity=23.7327188940092, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581345, Length=438, Percent_Identity=22.1461187214612, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43471; Mature: 43471

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIVVTGMGLVSPLGTGVELAWRRLLDGGSGLRLLSDDVVGELPAKVGGIVPDVTKDVE
CCCEEEECCHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHH
AGFDPDRYITPKDQKKMDRFIQFAMAATEEAVKQAGWMPTDEAKRERTATIIASGVGGFP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCCHH
AIAEAVRIGETRGVRRLSPFTVPSFLVNLAAGQVSIRYGFRGPLGAPVTACAASVQAIGD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
AARLIRSGEADVAICGGAEACIDKVSLGGFAAARALSTGFNETPELASRPFDTARDGFVM
HHHHHHCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEE
GEGAGILVIETLEHALARGATPLAELVGYGTAADAYHMTSGPEDGDGARRAMEAALRQAN
ECCCCEEEHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
IPASEVKHLNAHATSTPVGDRGEIAAVATVFGRNGGIAVSATKSATGHLLGAAGGLEAIF
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCCCHHHHH
TILALRDQIAPPTRNLDQADAAADGIDIVGKTARSLPMDYAITNGFGFGGVNASALFRRW
HHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCC
S
C
>Mature Secondary Structure
MDRIVVTGMGLVSPLGTGVELAWRRLLDGGSGLRLLSDDVVGELPAKVGGIVPDVTKDVE
CCCEEEECCHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCCCHHHHHH
AGFDPDRYITPKDQKKMDRFIQFAMAATEEAVKQAGWMPTDEAKRERTATIIASGVGGFP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCCHH
AIAEAVRIGETRGVRRLSPFTVPSFLVNLAAGQVSIRYGFRGPLGAPVTACAASVQAIGD
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
AARLIRSGEADVAICGGAEACIDKVSLGGFAAARALSTGFNETPELASRPFDTARDGFVM
HHHHHHCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEE
GEGAGILVIETLEHALARGATPLAELVGYGTAADAYHMTSGPEDGDGARRAMEAALRQAN
ECCCCEEEHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
IPASEVKHLNAHATSTPVGDRGEIAAVATVFGRNGGIAVSATKSATGHLLGAAGGLEAIF
CCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCEEECCCCHHHHH
TILALRDQIAPPTRNLDQADAAADGIDIVGKTARSLPMDYAITNGFGFGGVNASALFRRW
HHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]