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The map label for this gene is yibH

Identifier: 209399731

GI number: 209399731

Start: 4614294

End: 4615430

Strand: Reverse

Name: yibH

Synonym: ECH74115_4967

Alternate gene names: 209399731

Gene position: 4615430-4614294 (Counterclockwise)

Preceding gene: 209399646

Following gene: 209397735

Centisome position: 82.83

GC content: 52.68

Gene sequence:

>1137_bases
ATGGATCTATTGATTGTTTTAACTTACGTGGCGCTGGCGTGGGCGGTCTTTAAAATCTTCCGCATTCCGGTAAATCAGTG
GACGCTGGCGACGGCGGCGCTGGGAGGCGTGTTTCTGGTGAGTGGTTTGATTTTATTGATGAACTACAACCACCCTTACA
CTTTTACCGCGCAAAAGGCAGTGATAGCGATCCCTATCACGCCACAGGTGACGGGAATTGTTACTGAAGTCACTGACAAG
AATAATCAGCTTATTCAAAAGGGCGAGGTGCTTTTTAAGCTCGACCCGGTTCGTTACCAGGCGCGAGTTGACAGACTTCA
GGCTGACCTGATGACGGCGACGCATAATATAAAGACGCTGCGTGCGCAGCTCACTGAAGCGCAGGCCAACACCACCCAGG
TTTCAGCGGAGCGCGACCGTCTGTTTAAAAATTATCAACGTTACTTGAAAGGCAGCCAGGCGGCGGTGAATCCGTTCTCG
GAACGTGACATCGACGATGCGCGGCAAAATTTCCTCGCGCAGGATGCGCTGGTGAAAGGCTCGGTGGCGGAGCAGGCGCA
GATCCAGAGCCAGCTCGACAGTATGGTTAACGGCGAGCAATCGCAGATTGTGAGCTTAAGAGCGCAACTTACTGAAGCAA
AATATAACCTTGAGCAGACTGTCATTCGCGCGCCGAGCAATGGCTACGTTACTCAGGTACTGATCCGCCCAGGTACATAC
GCAGCTGCCTTGCCGCTGCGTCCGGTGATGGTCTTCATCCCCGAGCAAAAACGGCAAATTGTCGCCCAATTTCGGCAAAA
CTCGCTGTTACGTCTGAAACCCGGCGATGATGCGGAAGTGGTGTTTAACGCGCTACCTGGGCAGGTGTTTCACGGCAAAC
TGACTAGTATTTTACCTGTCGTGCCAGGCGGTTCTTATCAGGCGCAGGGGGTATTGCAATCATTAACGGTCGTGCCCGGC
ACGGACGGTGTGCTGGGAACCATTGAACTGGACCCTAACGATGATATCGATGCCTTACCCGACGGCATCTACGCCCAGGT
GGCGGTTTACTCCGACCATTTCAGCCATGTTTCGGTGATGCGGAAAGTGCTGCTAAGAATGACCAGCTGGATGCATTATC
TTTATTTGGATCATTGA

Upstream 100 bases:

>100_bases
ACCCGGAAATCGCCTCACTTTCTGACCGAATTTCCCGGCTGGAGCATCAACTCGCCGCCGAGAAAAAGACTGACTATTCC
ACGTTCCCGGAGATCTAATT

Downstream 100 bases:

>100_bases
GGGGGAGGGGGGAGATTATGGAACTTTGCTCCTTGTAAGGACTAATTATTTTTGCATATTACTTCATTAGCTGCGATGAT
TTTTCTTTAATATTCATTAT

Product: auxiliary transport protein, membrane fusion protein (MFP) family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDLLIVLTYVALAWAVFKIFRIPVNQWTLATAALGGVFLVSGLILLMNYNHPYTFTAQKAVIAIPITPQVTGIVTEVTDK
NNQLIQKGEVLFKLDPVRYQARVDRLQADLMTATHNIKTLRAQLTEAQANTTQVSAERDRLFKNYQRYLKGSQAAVNPFS
ERDIDDARQNFLAQDALVKGSVAEQAQIQSQLDSMVNGEQSQIVSLRAQLTEAKYNLEQTVIRAPSNGYVTQVLIRPGTY
AAALPLRPVMVFIPEQKRQIVAQFRQNSLLRLKPGDDAEVVFNALPGQVFHGKLTSILPVVPGGSYQAQGVLQSLTVVPG
TDGVLGTIELDPNDDIDALPDGIYAQVAVYSDHFSHVSVMRKVLLRMTSWMHYLYLDH

Sequences:

>Translated_378_residues
MDLLIVLTYVALAWAVFKIFRIPVNQWTLATAALGGVFLVSGLILLMNYNHPYTFTAQKAVIAIPITPQVTGIVTEVTDK
NNQLIQKGEVLFKLDPVRYQARVDRLQADLMTATHNIKTLRAQLTEAQANTTQVSAERDRLFKNYQRYLKGSQAAVNPFS
ERDIDDARQNFLAQDALVKGSVAEQAQIQSQLDSMVNGEQSQIVSLRAQLTEAKYNLEQTVIRAPSNGYVTQVLIRPGTY
AAALPLRPVMVFIPEQKRQIVAQFRQNSLLRLKPGDDAEVVFNALPGQVFHGKLTSILPVVPGGSYQAQGVLQSLTVVPG
TDGVLGTIELDPNDDIDALPDGIYAQVAVYSDHFSHVSVMRKVLLRMTSWMHYLYLDH
>Mature_378_residues
MDLLIVLTYVALAWAVFKIFRIPVNQWTLATAALGGVFLVSGLILLMNYNHPYTFTAQKAVIAIPITPQVTGIVTEVTDK
NNQLIQKGEVLFKLDPVRYQARVDRLQADLMTATHNIKTLRAQLTEAQANTTQVSAERDRLFKNYQRYLKGSQAAVNPFS
ERDIDDARQNFLAQDALVKGSVAEQAQIQSQLDSMVNGEQSQIVSLRAQLTEAKYNLEQTVIRAPSNGYVTQVLIRPGTY
AAALPLRPVMVFIPEQKRQIVAQFRQNSLLRLKPGDDAEVVFNALPGQVFHGKLTSILPVVPGGSYQAQGVLQSLTVVPG
TDGVLGTIELDPNDDIDALPDGIYAQVAVYSDHFSHVSVMRKVLLRMTSWMHYLYLDH

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family

Homologues:

Organism=Escherichia coli, GI1790024, Length=378, Percent_Identity=100, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1790012, Length=378, Percent_Identity=77.2486772486772, Blast_Score=619, Evalue=1e-179,
Organism=Escherichia coli, GI1790519, Length=254, Percent_Identity=27.1653543307087, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081951, Length=254, Percent_Identity=24.4094488188976, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788711, Length=238, Percent_Identity=22.6890756302521, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YIBH_ECO57 (P0AFV1)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A86035
- PIR:   A98188
- RefSeq:   NP_290177.1
- RefSeq:   NP_312500.1
- ProteinModelPortal:   P0AFV1
- SMR:   P0AFV1
- EnsemblBacteria:   EBESCT00000027162
- EnsemblBacteria:   EBESCT00000055586
- GeneID:   915586
- GeneID:   960955
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5021
- KEGG:   ecs:ECs4473
- GeneTree:   EBGT00050000009283
- HOGENOM:   HBG298323
- OMA:   SPFTELE
- ProtClustDB:   CLSK880732
- BioCyc:   ECOL83334:ECS4473-MONOMER
- InterPro:   IPR006143

Pfam domain/function: PF00529 HlyD

EC number: NA

Molecular weight: Translated: 41989; Mature: 41989

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe9dc290)-; HASH(0xed3604c)-; HASH(0x1232e9ac)-; HASH(0x1288015c)-; HASH(0x1284ea90)-; HASH(0x127f7228)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLIVLTYVALAWAVFKIFRIPVNQWTLATAALGGVFLVSGLILLMNYNHPYTFTAQKA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCE
VIAIPITPQVTGIVTEVTDKNNQLIQKGEVLFKLDPVRYQARVDRLQADLMTATHNIKTL
EEEEECCCCCCEEEEEECCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
RAQLTEAQANTTQVSAERDRLFKNYQRYLKGSQAAVNPFSERDIDDARQNFLAQDALVKG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCC
SVAEQAQIQSQLDSMVNGEQSQIVSLRAQLTEAKYNLEQTVIRAPSNGYVTQVLIRPGTY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCEEEEEECCCCE
AAALPLRPVMVFIPEQKRQIVAQFRQNSLLRLKPGDDAEVVFNALPGQVFHGKLTSILPV
EEECCCCEEEEEECCHHHHHHHHHHHCCEEEECCCCCHHHHEECCCCCCCCCCHHHHEEE
VPGGSYQAQGVLQSLTVVPGTDGVLGTIELDPNDDIDALPDGIYAQVAVYSDHFSHVSVM
CCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHH
RKVLLRMTSWMHYLYLDH
HHHHHHHHHHHHEEEECH
>Mature Secondary Structure
MDLLIVLTYVALAWAVFKIFRIPVNQWTLATAALGGVFLVSGLILLMNYNHPYTFTAQKA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCE
VIAIPITPQVTGIVTEVTDKNNQLIQKGEVLFKLDPVRYQARVDRLQADLMTATHNIKTL
EEEEECCCCCCEEEEEECCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
RAQLTEAQANTTQVSAERDRLFKNYQRYLKGSQAAVNPFSERDIDDARQNFLAQDALVKG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHCC
SVAEQAQIQSQLDSMVNGEQSQIVSLRAQLTEAKYNLEQTVIRAPSNGYVTQVLIRPGTY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCEEEEEECCCCE
AAALPLRPVMVFIPEQKRQIVAQFRQNSLLRLKPGDDAEVVFNALPGQVFHGKLTSILPV
EEECCCCEEEEEECCHHHHHHHHHHHCCEEEECCCCCHHHHEECCCCCCCCCCHHHHEEE
VPGGSYQAQGVLQSLTVVPGTDGVLGTIELDPNDDIDALPDGIYAQVAVYSDHFSHVSVM
CCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEEHHHHHHHHHH
RKVLLRMTSWMHYLYLDH
HHHHHHHHHHHHEEEECH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796