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The map label for this gene is cysC

Identifier: 209399413

GI number: 209399413

Start: 3698307

End: 3698912

Strand: Reverse

Name: cysC

Synonym: ECH74115_4002

Alternate gene names: 209399413

Gene position: 3698912-3698307 (Counterclockwise)

Preceding gene: 209400153

Following gene: 209400636

Centisome position: 66.38

GC content: 52.15

Gene sequence:

>606_bases
ATGGCGCTGCATGACGAAAACGTCGTCTGGCATAGCCATCCGGTCACTGTGCAACAACGCGAGCTACACCACGGTCATCG
TGGTGTAGTGCTGTGGTTTACCGGCCTCTCCGGGTCCGGTAAATCAACGGTCGCCGGGGCGCTGGAGGAGGCGTTACATA
AACTCGGCGTCAGTACGTATCTGCTGGATGGCGACAATGTTCGCCACGGATTATGCAGCGATCTCGGTTTTAGCGATGCC
GATCGTAAAGAGAATATCCGTCGCGTCGGTGAAGTGGCGAATTTGATGGTTGAAGCCGGACTGGTGGTGCTGACCGCATT
TATCTCGCCACACCGCGCCGAACGCCAGATGGTTCGCGAACGCGTAGGAGAAGGGCGCTTTATCGAAGTGTTTGTCGATA
CGCCACTGGCGATTTGCGAAGCCCGCGATCCAAAAGGCTTATATAAGAAAGCGCGTGCCGGTGAACTGCGCAACTTTACG
GGAATAGATTCCGTTTACGAAGCGCCTGAATCGGCAGAAATTCATCTCAATGGTGAACAATTAGTAACAAATTTGGTACA
GCAATTATTAGATCTGTTGAGACAGAACGATATTATCAGATCCTGA

Upstream 100 bases:

>100_bases
CTGCGCCATCTGAATTTAGTGCATTCGAACTGGAATTGAATGCCCTGGTTCGCCGCCACTTTCCACACTGGGGCGCGCGC
GATTTGCTGGGGGAGAAATA

Downstream 100 bases:

>100_bases
GACACCACCGGGTTTCCATGCCCGGTTCGTCAAAGTAACAGGATCAAATATGCGTAATAGCCATAACATTACACTAACAA
ATAACGACAGCCTTACTGAG

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDA
DRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFT
GIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS

Sequences:

>Translated_201_residues
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDA
DRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFT
GIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
>Mature_200_residues
ALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDAD
RKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTG
IDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=201, Percent_Identity=51.2437810945274, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI34447231, Length=201, Percent_Identity=50.2487562189055, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI62912492, Length=201, Percent_Identity=50.2487562189055, Blast_Score=191, Evalue=4e-49,
Organism=Escherichia coli, GI1789107, Length=201, Percent_Identity=100, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17542422, Length=201, Percent_Identity=51.2437810945274, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322852, Length=197, Percent_Identity=47.7157360406091, Blast_Score=189, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24667040, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24667032, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24667028, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI24667036, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=9e-45,
Organism=Drosophila melanogaster, GI116007838, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24667044, Length=200, Percent_Identity=47.5, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_ECO24 (A7ZQJ4)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001464073.1
- ProteinModelPortal:   A7ZQJ4
- SMR:   A7ZQJ4
- STRING:   A7ZQJ4
- EnsemblBacteria:   EBESCT00000020220
- GeneID:   5589634
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_3051
- eggNOG:   COG0529
- GeneTree:   EBGT00050000011347
- HOGENOM:   HBG309946
- OMA:   ITITAFV
- ProtClustDB:   PRK03846
- BioCyc:   ECOL331111:ECE24377A_3051-MONOMER
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 22322; Mature: 22190

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTY
CCCCCCCEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEE
LLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRE
EECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQ
HHCCCCEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEECHHH
LVTNLVQQLLDLLRQNDIIRS
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTY
CCCCCCEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEE
LLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRE
EECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQ
HHCCCCEEEEEECCCHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEECHHH
LVTNLVQQLLDLLRQNDIIRS
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA