Click here to switch to the map view.

The map label for this gene is ugd

Identifier: 209398959

GI number: 209398959

Start: 2735345

End: 2736511

Strand: Reverse

Name: ugd

Synonym: ECH74115_2961

Alternate gene names: 209398959

Gene position: 2736511-2735345 (Counterclockwise)

Preceding gene: 209400871

Following gene: 209399038

Centisome position: 49.11

GC content: 43.44

Gene sequence:

>1167_bases
ATGAAAATCACCATTTCCGGTACTGGCTATGTAGGCTTGTCAAACGGGCTTCTAATCGCTCAAAATCATGAGGTTGTGGC
ATTAGATATTTTACCGTCACGCGTTGCTATGCTGAATGATCGGATATCTCCTATTGTTGATAAGGAAATTCAGCAGTTTT
TGCAATCAGATAAAATACACTTTAATGCCACATTAGATAAAAATGAAGCCTACCGGGATGCTGATTATGTCATCATCGCC
ACTCCAACCGACTATGATCCTAAAACTAATTATTTCAATACATCCAGTGTAGAATCAGTAATTAAAGACGTAGTTGAGAT
AAATCCTTATGCGGTTATGGTCATCAAATCAACGGTTCCCGTTGGTTTTACCGAAGCGATGCATAAGAAATATCGTACTG
AAAATATTATTTTCTCTCCGGAATTTCTCCGCGAAGGTAAAGCTCTTTACGATAACCTTCATCCGTCACGTATTGTAATC
GGTGAGCGTTCGGAACGCGCAGAACGTTTTGCTGCGTTATTACAGGAAGGCGCGATTAAGCAAAATATCCCAACCCTGTT
TACCGACTCCACTGAAGCAGAAGCGATTAAACTTTTTGCAAACACCTACCTCGCGATGCGCGTGGCGTACTTTAACGAAC
TGGATAGCTACGCAGAAAGTTTAGGTCTGAATTCCCGTCAAATAATCGAAGGCGTTTGTCTCGACCCACGTATTGGCAAC
CATTACAACAATCCGTCGTTTGGTTATGGTGGTTATTGTTTGCCGAAAGATACCAAGCAGTTACTGGCGAACTACCAGTC
TGTGCCGAATAACCTGATCTCGGCAATTGTCGATGCTAACCGCACGCGTAAAGATTTTATTGCCGATGCCATTTTGTCAC
GCAAGCCGCAAGTGGTAGGTATTTATCGTCTGATTATGAAGAGCGGTTCAGATAACTTCCGTGCGTCTTCTATTCAGGGG
ATTATGAAGCGTATCAAGGCGAAAGGTGTTGAAGTAATCATCTACGAGCCAGTGATGAAAGAAGACTCATTCTTCAACTC
TCGCCTGGAACGTGATCTCGCCACCTTCAAACAACAAGCCGACGTCATTATTTCCAACCGTATGGCAGAAGAGCTTAGGG
ATGTGGCAGATAAGGTCTACACCCGCGATCTCTTTGGCAGCGACTAA

Upstream 100 bases:

>100_bases
CTGCGTTGACCATCGAACAACGTAGCGTTAAAACTTTTAGCTCTTATCAGGATGTTAAAAACATCATGATTCACAGTTAA
GTTAATTCTGAGAGCATGAA

Downstream 100 bases:

>100_bases
CATCTTGTTATCAGGGCTATTTACGCCCTGATTGTCTTTTGTTACCTCCGCAATAATTCATTATTTTTATCACTTATCCT
ATAGCATTCACAGGGATTAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD

Sequences:

>Translated_388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD
>Mature_388_residues
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIHFNATLDKNEAYRDADYVIIA
TPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVPVGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVI
GERSERAERFAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVGIYRLIMKSGSDNFRASSIQG
IMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQADVIISNRMAEELRDVADKVYTRDLFGSD

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4507813, Length=368, Percent_Identity=26.6304347826087, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI296040438, Length=263, Percent_Identity=26.2357414448669, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI296040443, Length=353, Percent_Identity=23.2294617563739, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=99.2268041237113, Blast_Score=790, Evalue=0.0,
Organism=Escherichia coli, GI48994968, Length=376, Percent_Identity=23.936170212766, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560350, Length=400, Percent_Identity=26, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17136908, Length=367, Percent_Identity=26.158038147139, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UDG_ECO57 (Q7DBF9)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- RefSeq:   NP_288533.1
- RefSeq:   NP_310856.1
- ProteinModelPortal:   Q7DBF9
- SMR:   Q7DBF9
- EnsemblBacteria:   EBESCT00000024658
- EnsemblBacteria:   EBESCT00000055505
- GeneID:   913058
- GeneID:   962086
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z3190
- KEGG:   ecs:ECs2829
- GeneTree:   EBGT00050000010460
- HOGENOM:   HBG400967
- OMA:   LNFRATT
- ProtClustDB:   PRK15057
- BioCyc:   ECOL83334:ECS2829-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- Gene3D:   G3DSA:3.40.50.1870
- PANTHER:   PTHR11374
- PIRSF:   PIRSF000124
- TIGRFAMs:   TIGR03026

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N; SSF48179 6DGDH_C_like; SSF52413 UDP-Glc/GDP-Man_DH_C

EC number: =1.1.1.22

Molecular weight: Translated: 43713; Mature: 43713

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: ACT_SITE 253-253

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIH
CEEEEECCCEEEECCCEEEECCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
VGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK
CCHHHHHHHHHCCCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCEECCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DVIISNRMAEELRDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKITISGTGYVGLSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSDKIH
CEEEEECCCEEEECCCEEEECCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHCCEE
FNATLDKNEAYRDADYVIIATPTDYDPKTNYFNTSSVESVIKDVVEINPYAVMVIKSTVP
EEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCC
VGFTEAMHKKYRTENIIFSPEFLREGKALYDNLHPSRIVIGERSERAERFAALLQEGAIK
CCHHHHHHHHHCCCCEEECHHHHHCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCHH
QNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESLGLNSRQIIEGVCLDPRIGN
HCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCEECCCCCCC
HYNNPSFGYGGYCLPKDTKQLLANYQSVPNNLISAIVDANRTRKDFIADAILSRKPQVVG
CCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHH
IYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYEPVMKEDSFFNSRLERDLATFKQQA
HHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
DVIISNRMAEELRDVADKVYTRDLFGSD
HHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796