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The map label for this gene is nadC [H]

Identifier: 209398277

GI number: 209398277

Start: 122222

End: 123115

Strand: Reverse

Name: nadC [H]

Synonym: ECH74115_0115

Alternate gene names: 209398277

Gene position: 123115-122222 (Counterclockwise)

Preceding gene: 209397094

Following gene: 209396006

Centisome position: 2.21

GC content: 53.58

Gene sequence:

>894_bases
ATGCCGCCTCGCCGCTATAACCCTGACACCCGACGTGACGAGCTGCTGGAACGCATTAATCTCGATATCCCCGGCGCGGT
GGCCCAGGCGCTGCGGGAAGATTTAGGCGGAACAGTCGATGCCAACAATGACATTACGGCAAAACTTTTACCGGAAAATT
CTCGCTCTCATGCCACGGTGATCACCCGCGAGAATGGCGTATTTTGCGGCAAACGCTGGGTTGAAGAGGTGTTTATTCAA
CTGGCAGGCGACGATGTCACCATAATCTGGCATGTGGATGACGGCGATGTCATCAACGCCAATCAACCCTTGTTCGAACT
TGAAGGCCCATCCCGCGTGCTGTTAACGGGCGAACGCACTGCGCTTAATTTTGTGCAAACCCTTTCAGGAGTTGCCAGTA
AGGTACGCCACTATGTCGAATTACTGGAAGGCACCAACACGCAGTTGTTGGATACGCGTAAAACCTTACCCGGTCTGCGT
TCAGCGCTGAAATACGCGGTACTTTGCGGCGGCGGAGCGAATCACCGTCTGGGGCTTTCTGATGCCTTCCTGATCAAAGA
AAACCATATTATTGCCTCCGGCTCAGTGCGCCAGGCGGTCGAAAAAGCGTCCTGGCTGCACCCGGATGCGCCAGTAGAAG
TCGAAGTAGAGAATCTGGAAGAACTTGATGAAGCCCTGAAAGCAGGAGCCGATATCATCATGCTGGATAACTTCGAAACA
GAACAGATGCGCGAAGCCGTCAAACGCACCAACGGCAAGGCGCTACTGGAAGTGTCTGGCAACGTCACTGACAAAACACT
GCGCGAATTTGCCGAAACGGGCGTGGACTTTATCTCCGTCGGTGCGCTAACTAAGCACGTACAGGCACTCGACCTTTCAA
TGCGTTTTCGCTAG

Upstream 100 bases:

>100_bases
GTTCTAACAACATGCAGGATCTCCTTATATGTGGTGCTAATACCCGGTTCAGAGTAGCATGTTTCTACCTTATGATTCGT
TAGCTATCTGGAGTTTTAAC

Downstream 100 bases:

>100_bases
TTGCTGACAGATTTATCCGCTCCATAGTGGGCGGATAATCTCCCCTTCCCCAACCTTCTTCGTAACGCCTCGCAAATTTC
TTGTCTTTCGCTGCAACGAA

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQ
LAGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLR
SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR

Sequences:

>Translated_297_residues
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQ
LAGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLR
SALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
>Mature_296_residues
PPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQL
AGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRS
ALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETE
QMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=272, Percent_Identity=34.5588235294118, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1786299, Length=297, Percent_Identity=99.6632996632997, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=32.9411764705882, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32773; Mature: 32641

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATV
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEE
ITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERT
EEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEECCCCEEEEECCHH
ALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
DAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCH
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
PPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATV
CCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEE
ITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQPLFELEGPSRVLLTGERT
EEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCCCEEEECCCCEEEEECCHH
ALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLS
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
DAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFET
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEECCCCH
EQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7959070; 8561507; 8202364; 9278503; 2691840; 2607970; 8419294 [H]