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The map label for this gene is fbaA [H]

Identifier: 209396544

GI number: 209396544

Start: 5236476

End: 5237336

Strand: Reverse

Name: fbaA [H]

Synonym: ECH74115_5597

Alternate gene names: 209396544

Gene position: 5237336-5236476 (Counterclockwise)

Preceding gene: 209397336

Following gene: 209396508

Centisome position: 93.99

GC content: 54.94

Gene sequence:

>861_bases
ATGCCATTGATTTCTCTCGCTGAAGGGCTGGCACATGCCCGCGAACATCACTATTCGTTAGGTGCGTTTAATGTGCTGGA
CTCGCACTTTTTACGCGCCTTGTTTGCTGCTGCCAGACAAGAACGTTCGCCCTTTATTATCAACATTGCCGAAGTACATT
TTAAATATATCTCGCTGGATTCCCTGGTCGAGACAGTGAAATTTGAAGCGGCGCGTCATGACATTCCGGTGGTGTTAAAT
CTCGATCACGGACTGCATTTTGAATCGGTGGTGCAAGCGTTGCGGCTGGGATTCAGCTCGGTAATGTTTGATGGCTCCAC
GCTGGGGTATGAAGAAAATGTCCGCCAGACGCGGGAAGTGGTGAAAATGTGCCATGCCGTTGGCGTATCGGTAGAAGCTG
AACTGGGCGCGGTGGGTGGCGACGAAGGCGGTGCACTCTATGGTCATGCCGATGAATCCCTGTTTACCGATCCGCAACTG
GCGCGTGATTTTGTCGACCGTACCGGCATTGACGCGCTGGCCGTGGCGATTGGCAATGCACACGGCAAATATCGCGGCGA
ACCGAAACTCGATTTCCCGCGCCTCGACGCTATCCGCCAGCAGGCTGCTATCCCGCTGGTATTACACGGCGGCTCAGGGA
TTAGCGATGCCGATTTCCGCCGCGCCATCGAACTGGGTATCCACAAAATCAATTTCTACACTGGCATGTCGCAAGCGGCG
CTGGCTGCCGTTGAGGCCCGAATGGCGCACCGTCAGCCGATGTATGACGAGTTTGCCGAGTTACTGCTGGCAGTGGAAGC
CGCCATCAGCGATACGGTTGCACAACAGATGCGTATTTTTGGCAGTGCGGGGCAGGCATGA

Upstream 100 bases:

>100_bases
TACAGCCACTGGACCGCTACAACCTGATTGACGAAGACGAACCTGCACAGTTGGTATTGTGTAACGAATACCGCCAGTTC
CGCTGAATAAGGATAACGTT

Downstream 100 bases:

>100_bases
TGGAGCGTAAAGGGATTATCGCCGCAGGCAATATGTTGGTTGACCACGTCCATCAGATTATCCAGTGGCCAGAGCGCGGC
TGGCTGGCGGAGATCACCCA

Product: hypothetical protein

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLDSLVETVKFEAARHDIPVVLN
LDHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGHADESLFTDPQL
ARDFVDRTGIDALAVAIGNAHGKYRGEPKLDFPRLDAIRQQAAIPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA
LAAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA

Sequences:

>Translated_286_residues
MPLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLDSLVETVKFEAARHDIPVVLN
LDHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGHADESLFTDPQL
ARDFVDRTGIDALAVAIGNAHGKYRGEPKLDFPRLDAIRQQAAIPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA
LAAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA
>Mature_285_residues
PLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLDSLVETVKFEAARHDIPVVLNL
DHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGHADESLFTDPQLA
RDFVDRTGIDALAVAIGNAHGKYRGEPKLDFPRLDAIRQQAAIPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAAL
AAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1788072, Length=276, Percent_Identity=39.8550724637681, Blast_Score=193, Evalue=9e-51,
Organism=Escherichia coli, GI87082041, Length=286, Percent_Identity=37.0629370629371, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789526, Length=285, Percent_Identity=36.140350877193, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789293, Length=279, Percent_Identity=24.0143369175627, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=286, Percent_Identity=27.972027972028, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31121; Mature: 30990

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLD
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
SLVETVKFEAARHDIPVVLNLDHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHH
VKMCHAVGVSVEAELGAVGGDEGGALYGHADESLFTDPQLARDFVDRTGIDALAVAIGNA
HHHHHHHCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
HGKYRGEPKLDFPRLDAIRQQAAIPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA
CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHEEHHCCHHHHH
LAAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLISLAEGLAHAREHHYSLGAFNVLDSHFLRALFAAARQERSPFIINIAEVHFKYISLD
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
SLVETVKFEAARHDIPVVLNLDHGLHFESVVQALRLGFSSVMFDGSTLGYEENVRQTREV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHH
VKMCHAVGVSVEAELGAVGGDEGGALYGHADESLFTDPQLARDFVDRTGIDALAVAIGNA
HHHHHHHCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
HGKYRGEPKLDFPRLDAIRQQAAIPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA
CCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHEEHHCCHHHHH
LAAVEARMAHRQPMYDEFAELLLAVEAAISDTVAQQMRIFGSAGQA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2457578; 1640835; 9353933; 9384377; 1556067 [H]