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The map label for this gene is rnb [H]

Identifier: 209396001

GI number: 209396001

Start: 1814692

End: 1816626

Strand: Reverse

Name: rnb [H]

Synonym: ECH74115_1923

Alternate gene names: 209396001

Gene position: 1816626-1814692 (Counterclockwise)

Preceding gene: 209400889

Following gene: 209396230

Centisome position: 32.6

GC content: 52.76

Gene sequence:

>1935_bases
ATGTTTCAGGACAACCCGCTGCTAGCGCAGCTTAAACAGCAACTGCATTCCCAGACGCCACGCGCTGAAGGGGTGGTAAA
AGCCACAGAAAAAGGTTTTGGCTTCCTGGAAGTCGACGCGCAAAAAAGTTATTTCATTCCGCCGCCGCAGATGAAAAAAG
TCATGCATGGCGACCGAATTATCGCGGTGATCCACAGTGAAAAAGAACGTGAATCCGCAGAGCCAGAAGAACTGGTTGAA
CCGTTTCTGACTCGTTTCGTGGGTAAAGTTCAGGGCAAAAATGACCGTCTGGCCATCGTTCCTGATCATCCACTCTTAAA
AGACGCCATTCCTTGCCGCGCAGCCCGTGGTCTGAACCACGAGTTTAAAGAAGGCGACTGGGCAGTTGCCGAAATGCGCC
GTCATCCGCTGAAAGGCGATCGTTCTTTCTATGCTGAACTGACACAATACATCACTTTTGGTGACGACCACTTTGTACCG
TGGTGGGTTACCCTTGCGCGCCATAATCTGGAAAAAGAAGCACCAGACGGCGTCGCTACCGAAATGCTCGATGAAGGTCT
GGTTCGTAAAGATCTGACCGCGCTGGATTTTGTCACCATCGACAGTGCCAGCACAGAAGATATGGATGACGCCCTTTTCG
CTAAGGCGTTGCCGGATGACAAACTTCAGCTGATTGTGGCGATTGCCGATCCAACCGCGTGGATTGCTGAAGGCAGCAAG
CTGGACAAAGCCGCGAAAATTCGCGCATTCACCAACTATCTGCCTGGCTTCAACATCCCTATGCTGCCTCGCGAGCTTTC
TGACGATCTCTGCTCACTGCGCGCCAATGAAGTCCGCCCGGTACTGGCATGCCGCATGACGCTCTCCGCTGATGGCACCA
TTGAAGATAATATCGAATTCTTTGCCGCCACCATCGAATCCAAAGCGAAGCTGGTGTATGACCAGGTTTCTGACTGGCTG
GAGAATACCGGTGACTGGCAGCCTGAAAGTGAAGCAATTGCCGAACAAGTCCGTTTGCTAGCGCAAATTTGCCAACGCCG
CGGCGAGTGGCGTCATAACCACGCACTGGTGTTTAAAGATCGCCCGGATTACCGCTTTATTCTCGGTGAAAAAGGTGAAG
TGCTGGATATCGTCGCCGAGCCTCGTCGCATTGCCAACCGTATCGTCGAAGAAGCGATGATTGCCGCTAACATTTGTGCA
GCTCGCGTACTGCGCGATAAGCTCGGTTTTGGTATCTATAACGTGCATATGGGCTTTGATCCGGCGAATGCCGACGCGCT
GGCAGCGTTGCTGAAAACGCACGGTCTGCATGTCGATGCCGAAGAAGTGCTCACGCTGGACGGTTTCTGCAAACTGCGTC
GTGAACTGGATGCGCAACCAACTGGTTTCCTCGACAGCCGCATTCGTCGCTTCCAGTCATTTGCTGAAATTAGCACTGAA
CCCGGTCCTCACTTTGGCCTCGGTCTGGAAGCATACGCCACCTGGACTTCGCCGATCCGTAAATATGGCGACATGATCAA
CCACCGTCTGCTGAAAGCGGTTATCAAAGGCGAAACTGCGACGCGTCCACAGGATGAAATCACTGTCCAAATGGCCGAGC
GTCGCCGTCTCAATCGGATGGCAGAACGTGATGTTGGTGACTGGTTATACGCACGCTTCCTGAAAGACAAAGCCGGGACC
GACACCCGTTTCGCAGCGGAAATTGTCGATATCAGCCGTGGCGGCATGCGTGTTCGTTTGGTTGATAACGGCGCTATCGC
CTTTATTCCTGCACCTTTCTTACACGCTGTGCGCGATGAACTGGTTTGCAGCCAGGAAAACGGCACCGTACAAATTAAAG
GTGAAACGGTTTATAAAGTAACTGACGTTATTGACGTCACCATTGCCGAAGTCCGCATGGAAACCCGCAGCATTATTGCG
CGCCCGGTCGCGTAA

Upstream 100 bases:

>100_bases
CGCTTAAAAATCGCGTTGGGTGAGACATATTAACCTTGCCGCGTCAGACAGATTCGCGTAAAACTGTCAGCCGCTCTAAT
GGCCACCAAAATAGACAATT

Downstream 100 bases:

>100_bases
TCTCCTTTCACGGCCCATTCCTTATGAATGGGCCGTTTATTTCCCCGCTCTACCTTCATCATATCCCGGCAGTTTTTTAA
CTGACTTTCGTTTGAAAACT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSK
LDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWL
ENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSK
LDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWL
ENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVP
WWVTLARHNLEKEAPDGVATEMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSK
LDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEFFAATIESKAKLVYDQVSDWL
ENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=387, Percent_Identity=25.5813953488372, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI190014625, Length=387, Percent_Identity=25.5813953488372, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI134288890, Length=365, Percent_Identity=29.041095890411, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI219521928, Length=456, Percent_Identity=25, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI19115966, Length=456, Percent_Identity=25, Blast_Score=95, Evalue=3e-19,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=99.8447204968944, Blast_Score=1322, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=651, Percent_Identity=26.1136712749616, Blast_Score=174, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI212645896, Length=468, Percent_Identity=26.7094017094017, Blast_Score=119, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=27.1393643031785, Blast_Score=117, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=420, Percent_Identity=24.047619047619, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24649634, Length=370, Percent_Identity=28.1081081081081, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654592, Length=451, Percent_Identity=26.8292682926829, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19922976, Length=451, Percent_Identity=26.8292682926829, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24654597, Length=451, Percent_Identity=26.8292682926829, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72491; Mature: 72491

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCHHHHCCCCC
EFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVAT
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHH
EMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSK
HHHHHHHHHHCCCHHEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCC
LDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHEEEEECCCCCCCCCHHH
FAATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
RPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLKDAIPCRAARGLNH
EEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHCCCHHHHCCCCC
EFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVAT
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHH
EMLDEGLVRKDLTALDFVTIDSASTEDMDDALFAKALPDDKLQLIVAIADPTAWIAEGSK
HHHHHHHHHHCCCHHEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCC
LDKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSADGTIEDNIEF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEHHEEEEECCCCCCCCCHHH
FAATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
RPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTE
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDE
HHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA