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The map label for this gene is lldR [H]

Identifier: 209395948

GI number: 209395948

Start: 4629002

End: 4629778

Strand: Direct

Name: lldR [H]

Synonym: ECH74115_4977

Alternate gene names: 209395948

Gene position: 4629002-4629778 (Clockwise)

Preceding gene: 209398657

Following gene: 209396531

Centisome position: 83.08

GC content: 54.05

Gene sequence:

>777_bases
ATGATTGTTTTACCCAGACGCCTGTCAGACGAGGTTGCCGATCGTGTGCGGGCGCTGATTGATGAAAAAAACCTGGAAGC
GGGCATGAAGTTGCCCGCTGAGCGCCAACTGGCGATGCAACTCGGCGTATCACGTAATTCACTACGCGAGGCGCTGGCAA
AACTGGTGAGCGAAGGCGTGCTGCTCAGTCGACGCGGCGGCGGGACGTTTATTCGCTGGCGTCATGACACATGGTCGGAG
CAAAACATCGTCCAGCCGCTAAAAACGCTGATGGCCGATGATCCGGATTACAGTTTCGATATTCTGGAAGCCCGCTACGC
CATTGAAGCCAGCACCGCATGGCATGCGGCAATGCGCGCCACACCTGGCGACAAAGAAAAGATTCAGCTTTGCTTTGAAG
CAACGCTAAGTGAAGACCCGGATATCGCCTCACAAGCGGACGTTCGTTTTCATCTGGCGATTGCCGAAGCCTCACATAAC
ATCGTGCTGCTGCAAACCATACGCGGTTTCTTCGATGTCCTGCAATCCTCAGTGAAGCATAGCCGTCAGCGGATGTATCT
GGTGCCACCGGTTTTTTCACAACTGACCGAACAACATCAGGCTGTCATTGACGCCATTTTTGCTGGTGATGCCGACGGGG
CGCGTAAAGCAATGATGGCGCACCTTAGTTTTGTTCACACCACCATGAAACGATTCGATGAAGATCAGGCTCGCCACGCA
CGGATTACCCGCCTGCCCGGTGAGCATAATGAGCATTCGAGGGAGAAAAACGCATGA

Upstream 100 bases:

>100_bases
ATTTGTTCCGCTTTACTGTCAAACACAGCCTGATCTTCACCTGTATGGTGGGCGTGATCACCACGCTTCAGGCTTATGTC
TTAACGTGGATGATTCCTTA

Downstream 100 bases:

>100_bases
TTATTTCCGCAGCCAGCGATTATCGCGCCGCAGCGCAACGCATTCTGCCGCCGTTCCTGTTCCACTATATGGATGGTGGT
GCATATTCTGAATACACGCT

Product: DNA-binding transcriptional repressor LldR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTIRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA

Sequences:

>Translated_258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTIRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA
>Mature_258_residues
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHDTWSE
QNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHN
IVLLQTIRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
RITRLPGEHNEHSREKNA

Specific function: May be a regulatory protein for the LCT genes [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790032, Length=258, Percent_Identity=99.6124031007752, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI1786303, Length=231, Percent_Identity=38.0952380952381, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789353, Length=234, Percent_Identity=31.1965811965812, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790780, Length=232, Percent_Identity=30.1724137931034, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI87082208, Length=237, Percent_Identity=27.0042194092827, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29149; Mature: 29149

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGV
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LLSRRGGGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
TPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTIRGFFDVLQSSVKH
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGEHNEHSREKNA
HHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIVLPRRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGV
CEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LLSRRGGGTFIRWRHDTWSEQNIVQPLKTLMADDPDYSFDILEARYAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
TPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTIRGFFDVLQSSVKH
CCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHLSFVHTTMKRFDEDQARHA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGEHNEHSREKNA
HHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407843; 8041620; 9278503 [H]