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The map label for this gene is mtlD [H]

Identifier: 209395785

GI number: 209395785

Start: 4618340

End: 4619488

Strand: Direct

Name: mtlD [H]

Synonym: ECH74115_4970

Alternate gene names: 209395785

Gene position: 4618340-4619488 (Clockwise)

Preceding gene: 209396799

Following gene: 209400358

Centisome position: 82.88

GC content: 52.57

Gene sequence:

>1149_bases
ATGAAAGCATTACATTTTGGCGCAGGTAATATCGGTCGTGGCTTTATCGGTAAACTGCTGGCAGACGCGGGTATCCAACT
GACGTTTGCCGATGTCAATCAGGTGGTACTTGATGCCCTGAATGCCCGTCATAGCTATCAGGTTCATGTGGTCGGTGAAA
CCGAGCAGGTAGATACCGTTTCCGGCGTCGATGCTGTCAGCAGCATTGGTGATGATGTCGTTGATCTGATTGCTCAGGTC
GATTTAGTCACTACCGCCGTTGGCCCGGTTGTGCTGGAACGTATTGCTCCGGCTATCGCCAAAGGGCTGGTGAAACGTAA
AGAACAAGGTAATGAATCCCCGCTGAACATCATCGCCTGTGAAAACATGGTACGCGGTACCACGCAGCTGAAAGGTCATG
TGATGAACGCCCTACCAGAAGACGCCAAAGCGTGGGTAGAAGAACACGTTGGCTTTGTCGATTCCGCCGTTGACCGCATC
GTACCGCCTTCGGCTTCGGCAACTAACGATCCGCTGGAAGTGACGGTAGAAACTTTCAGCGAATGGATTGTCGATAAAAC
GCAGTTCAAAGGCGCACTGCCGAACATCCCAGGCATGGAGTTAACCGACAACCTGATGGCATTTGTCGAACGTAAACTCT
TCACCCTGAACACGGGTCATGCTATAACCGCGTACCTCGGAAAACTGGCCGGTCATCAGACCATTCGTGACGCTATTCTC
GACGAGAAAATCCGCGCGGTGGTAAAAGGTGCGATGGAAGAAAGTGGTGCGGTACTGATCAAGCGCTACGGCTTTGACGC
AGACAAACATGCGGCGTACATCCAGAAAATCCTCGGTCGTTTTGAGAACCCGTATCTGAAAGATGATGTAGAGCGCGTAG
GCCGTCAGCCGCTGCGTAAACTGAGTGCTGGCGACCGTCTGATCAAGCCATTGCTCGGTACGCTGGAATACAGCCTTCCG
CACAAGAATCTGATTCAGGGGATTGCTGGTGCAATGCACTTCCGCAGTGAAGACGATCCGCAGGCTCAGGAACTGGCAGC
ACTGATCGCTGACAAAGGTCCGCAGGCGGCGCTGGCACAGATTTCCGATCTTGATGCCAACAGCGAGGTTGTATCCGAGG
CGGTAACCGCTTATAAAGCAATGCAATAA

Upstream 100 bases:

>100_bases
AAGTAATCCAATCCTACCCTCTCCTCACGGAGAGGGTTTGGGTGAGGGAAAAGCCTCACCCCAGCCCTCTCGGGTAAAAA
CATTGATGAAGGTTAATACT

Downstream 100 bases:

>100_bases
TGGTGGACCAGGCGCAGGACACCCTGCGCCCGAATAACAGATTGTCAGATATGCAGGCAACAATGGAACAAACCCAGGCC
TTTGAAAACCGTGTGCTTGA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYSLP
HKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQISDLDANSEVVSEAVTAYKAMQ

Sequences:

>Translated_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYSLP
HKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQISDLDANSEVVSEAVTAYKAMQ
>Mature_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVDAVSSIGDDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYSLP
HKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQISDLDANSEVVSEAVTAYKAMQ

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=98.4293193717278, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI1787823, Length=267, Percent_Identity=28.8389513108614, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788497, Length=261, Percent_Identity=28.735632183908, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790779, Length=259, Percent_Identity=28.1853281853282, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 41199; Mature: 41199

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
SGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHHHH
EWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYSLPHKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHH
ISDLDANSEVVSEAVTAYKAMQ
HHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
SGVDAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHHHH
EWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYSLPHKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHH
ISDLDANSEVVSEAVTAYKAMQ
HHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA