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The map label for this gene is HutI

Identifier: 20806960

GI number: 20806960

Start: 466933

End: 468180

Strand: Direct

Name: HutI

Synonym: TTE0451

Alternate gene names: 20806960

Gene position: 466933-468180 (Clockwise)

Preceding gene: 20806959

Following gene: 20806961

Centisome position: 17.36

GC content: 39.26

Gene sequence:

>1248_bases
ATGAGAGCAGATTTATTAATATACAATATAAGTAAAATTTATACGCCGATTGGGACGAAACCTCTTTGTGGAGAAGATAT
GGAAAAAATAGAAGAGATAGAGAATGCTTACATAGCAATAAAAGATGGAAAAATTTTGGCGGCAGGGAAATCTCCTGCCG
CAATTTCTGCAGAGAGGGAAATTGACGCGAAAGGTATGATTGCACTCCCTGGATTTGTTGACCCTCACACCCATGTGATG
CATTATGGATCCAGAGAAAATGAAATGGCTCTAAAGCTTAAAGGTTATTCCTATATTGACATTTTAAAACAAGGCGGAGG
TATCCATTCCACAGTAAGAGCGACTAGAGAGGCCTCTGATGAGGCATTGCTTCAAAAGGCTTTAAAAAGCCTTGAAATCA
TGCTTTCTCATGGAGTGACTACTGTAGAGGTAAAAAGTGGGTATGGCCTTAATACAGAGCAAGAGATACGGCTTTTAAGA
CTTATGAACCAATTAAAAAGCCTTTCTGTTGTGGATATTGTGCCTACTTTTCTAGGAGCCCATGCTATTCCACAGGAGTT
TGAAGAGAACCCTTGGAGGTATGTGGAGAAAGTAATAAATGAGATGCTTCCTAAGGTAAAAGAGGAAGACCTGGCAGAGT
TTTGCGATGTATTCTGTGAAGAAGGGGCTTTTGATTATGAACAATCGAAGAAAATATTAGAGGAAGCTAAAAAACTGGGG
TTTAGACTAAAAATTCATGCGGATGAACTTACCCACAGTAAAGGTGGAGAATTGGCTGGGATATTAGGGGCTATAAGTGC
TGACCATTTAGAAGAAGTCTCTGATGAAGGAATAGACCTCATGAAAAAAGCAGGCACAGTGGCAGTCCTTTTGCCAGGGG
TTTCTTTCTTTTTGAATAGACCTTATGCTGATGCGAGGCGATTAATTGAGAGGGGATTGCCTGTTGCATTAGGTACAGAT
TACAATCCCGGTACAAGCCCTACAGAGAATTTACAGCTTATAATGTCATTTGCCTATATTAACATGAAAATGAGGGCAGA
GGAAATCCTAACAGCTGTTACATTAAATGCTGCCTGTGCTATTGATAGAGGTGATGAAATAGGGACTATAGAGGAAGGGA
AAAGAGCTGATATTGTCTTAGTTGATGCTCCAAATCTGGACTATATGATGTATCACTTTGGAATTAACCATGTAAATACA
GTGATAAAGGCAAAAGGAAATGATGTGGTTGTTATTGGAATAAAATAG

Upstream 100 bases:

>100_bases
TTCAAAAGCGTTGCTAGATGTTGCCGATTATTATTTGAGATTAGAAAATTTCTCCATGGATATGGTTTTGGAAAACAGAA
TTTACGAATGAGGTGTTCAT

Downstream 100 bases:

>100_bases
TTTTTATGTTACAATGAAAATGGGTGAAGAAGAATGTTTGCTGTATCCCAGAAGTTATTAGAAATATGTGAAAAATATAA
AATAGGTTTGGTGTACCTGT

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MRADLLIYNISKIYTPIGTKPLCGEDMEKIEEIENAYIAIKDGKILAAGKSPAAISAEREIDAKGMIALPGFVDPHTHVM
HYGSRENEMALKLKGYSYIDILKQGGGIHSTVRATREASDEALLQKALKSLEIMLSHGVTTVEVKSGYGLNTEQEIRLLR
LMNQLKSLSVVDIVPTFLGAHAIPQEFEENPWRYVEKVINEMLPKVKEEDLAEFCDVFCEEGAFDYEQSKKILEEAKKLG
FRLKIHADELTHSKGGELAGILGAISADHLEEVSDEGIDLMKKAGTVAVLLPGVSFFLNRPYADARRLIERGLPVALGTD
YNPGTSPTENLQLIMSFAYINMKMRAEEILTAVTLNAACAIDRGDEIGTIEEGKRADIVLVDAPNLDYMMYHFGINHVNT
VIKAKGNDVVVIGIK

Sequences:

>Translated_415_residues
MRADLLIYNISKIYTPIGTKPLCGEDMEKIEEIENAYIAIKDGKILAAGKSPAAISAEREIDAKGMIALPGFVDPHTHVM
HYGSRENEMALKLKGYSYIDILKQGGGIHSTVRATREASDEALLQKALKSLEIMLSHGVTTVEVKSGYGLNTEQEIRLLR
LMNQLKSLSVVDIVPTFLGAHAIPQEFEENPWRYVEKVINEMLPKVKEEDLAEFCDVFCEEGAFDYEQSKKILEEAKKLG
FRLKIHADELTHSKGGELAGILGAISADHLEEVSDEGIDLMKKAGTVAVLLPGVSFFLNRPYADARRLIERGLPVALGTD
YNPGTSPTENLQLIMSFAYINMKMRAEEILTAVTLNAACAIDRGDEIGTIEEGKRADIVLVDAPNLDYMMYHFGINHVNT
VIKAKGNDVVVIGIK
>Mature_415_residues
MRADLLIYNISKIYTPIGTKPLCGEDMEKIEEIENAYIAIKDGKILAAGKSPAAISAEREIDAKGMIALPGFVDPHTHVM
HYGSRENEMALKLKGYSYIDILKQGGGIHSTVRATREASDEALLQKALKSLEIMLSHGVTTVEVKSGYGLNTEQEIRLLR
LMNQLKSLSVVDIVPTFLGAHAIPQEFEENPWRYVEKVINEMLPKVKEEDLAEFCDVFCEEGAFDYEQSKKILEEAKKLG
FRLKIHADELTHSKGGELAGILGAISADHLEEVSDEGIDLMKKAGTVAVLLPGVSFFLNRPYADARRLIERGLPVALGTD
YNPGTSPTENLQLIMSFAYINMKMRAEEILTAVTLNAACAIDRGDEIGTIEEGKRADIVLVDAPNLDYMMYHFGINHVNT
VIKAKGNDVVVIGIK

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=410, Percent_Identity=36.3414634146341, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17555004, Length=370, Percent_Identity=39.1891891891892, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_THETN (Q8RCH7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622131.1
- ProteinModelPortal:   Q8RCH7
- SMR:   Q8RCH7
- GeneID:   997602
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0451
- NMPDR:   fig|273068.3.peg.667
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   TTEN273068:TTE0451-MONOMER
- BRENDA:   3.5.2.7
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 45776; Mature: 45776

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: BINDING 85-85 BINDING 98-98 BINDING 148-148 BINDING 181-181 BINDING 249-249

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADLLIYNISKIYTPIGTKPLCGEDMEKIEEIENAYIAIKDGKILAAGKSPAAISAERE
CCCCEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCEEEEECCCCCEECCCCC
IDAKGMIALPGFVDPHTHVMHYGSRENEMALKLKGYSYIDILKQGGGIHSTVRATREASD
CCCCCEEECCCCCCCCHHHEECCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHCHH
EALLQKALKSLEIMLSHGVTTVEVKSGYGLNTEQEIRLLRLMNQLKSLSVVDIVPTFLGA
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCC
HAIPQEFEENPWRYVEKVINEMLPKVKEEDLAEFCDVFCEEGAFDYEQSKKILEEAKKLG
CCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FRLKIHADELTHSKGGELAGILGAISADHLEEVSDEGIDLMKKAGTVAVLLPGVSFFLNR
EEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCHHHHHCC
PYADARRLIERGLPVALGTDYNPGTSPTENLQLIMSFAYINMKMRAEEILTAVTLNAACA
CHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IDRGDEIGTIEEGKRADIVLVDAPNLDYMMYHFGINHVNTVIKAKGNDVVVIGIK
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHEEEECCCEEEEEEEC
>Mature Secondary Structure
MRADLLIYNISKIYTPIGTKPLCGEDMEKIEEIENAYIAIKDGKILAAGKSPAAISAERE
CCCCEEEEEHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCEEEEECCCCCEECCCCC
IDAKGMIALPGFVDPHTHVMHYGSRENEMALKLKGYSYIDILKQGGGIHSTVRATREASD
CCCCCEEECCCCCCCCHHHEECCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHCHH
EALLQKALKSLEIMLSHGVTTVEVKSGYGLNTEQEIRLLRLMNQLKSLSVVDIVPTFLGA
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCC
HAIPQEFEENPWRYVEKVINEMLPKVKEEDLAEFCDVFCEEGAFDYEQSKKILEEAKKLG
CCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FRLKIHADELTHSKGGELAGILGAISADHLEEVSDEGIDLMKKAGTVAVLLPGVSFFLNR
EEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEECCHHHHHCC
PYADARRLIERGLPVALGTDYNPGTSPTENLQLIMSFAYINMKMRAEEILTAVTLNAACA
CHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
IDRGDEIGTIEEGKRADIVLVDAPNLDYMMYHFGINHVNTVIKAKGNDVVVIGIK
ECCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336