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The map label for this gene is HutU [H]

Identifier: 20806958

GI number: 20806958

Start: 464354

End: 466003

Strand: Direct

Name: HutU [H]

Synonym: TTE0449

Alternate gene names: 20806958

Gene position: 464354-466003 (Clockwise)

Preceding gene: 20806957

Following gene: 20806959

Centisome position: 17.27

GC content: 44.97

Gene sequence:

>1650_bases
ATGTCAAGAGTTGTAAGAGCACCTCGAGGGACAGAGCTTCACTGCAAAAACTGGCAGATAGAAGCTCCTTACAGAATGAT
TATGAACAACCTAGACCCTGAAGTGGCTGAAGATCCTGCAAACTTGATAGTGTACGGTGGGGCAGGAAAAGCCGCAAGAA
ATTGGGAAGCTTTTGACAAAATACTAGAAAGCCTTGAAAACCTGGAAGAGGATGAGACTTTGCTAGTTCAATCGGGAAAA
CCTGTAGGAATTTTCAAAACCCACGAGATGGCACCAAGAGTTTTGATTTCAAATGCCATGCTGGTTCCAAAATGGGCCAA
CTGGGAGACTTTTTGGGACCTTGAAGCAAAAGGGCTTACCATGTACGGCCAGATGACGGCAGGAAGCTGGATATATATAG
GCTCACAGGGAATTGTAGAAGGGACTTTTGAAACTTTTGCTGCTTTAGCCAAAAAGCACTTTGACGGAAGCTTAAAGGGC
AAGTTTGTCCTTTCAGCAGGGCTGGGAGGAATGGGCGGTGCTCAACCGCTGGCAATTACCATGTTAGATGGAGCCTGCCT
TATAGTCGAAGTTGATAGAAACAGGATAAAAAGAAGACTGGAGACTAAATACTTAGATGTAATGGCGGAAGACCTGGATG
AAGCCTTGGGAATGGTTATGAAGGCAAAAGAAGAAGGAAGGGCTTTATCTGTAGGATTGGTGGGCAATGCAGCAGATGTT
CATCCAGAACTTGTGAGAAGAGGCATAATCCCAGATGTTGTAACAGACCAAACCTCAGCCCATGACCCCTTAAATGGATA
TGTGCCAAATGGAATGACTTTAGATGAAGCTATAGCACTTAGAAAATCCAATCCTGAAGAATACATAAAGAGAGCTAAAA
AGGCGATGGCAGAGCATGTTTTAGCTATGCTTGAAATGCAGAAAAGAGGGGCTATAGTTTTTGACTACGGTAACAACATA
AGGAGAATGGCCTATGACGAAGGAGTAAAAGACGCCTTCAACATCCCAAGCTATGTTCCCGAGTATATAAGGGACCTGTT
CTGCGAGGGCAAAGGGCCTTTCCGCTGGGTGGCGTTGTCTGGTGACCCTGAAGACATTTACAAGACAGACCAGAAAGTAT
TAGAACTTTTCCCTGATGACCCCATACTCAATAGGTGGATTAGGTTGGCTAGAGAAAGAGTGAAATTCCAAGGGCTTCCT
GCGAGGATTTGCTGGCTGGGCTATGGTCAGAGAGCAGAATTTGGCCTTGCTATAAACGAGATGGTAAGAAAAGGAGAGCT
TAAAGCGCCAATTGTAATAGGAAGAGACCACCATGACACAGGGTCTGTGGCATCACCGTATAGAGAGACAGAGGCTATGA
AGGATGGAAGTGACGCTATAGCAGACTGGCCGATACTAAATGCGCTTTTAAACACTGCCTCAGGAGCTACATGGGTTTCT
GTACACCACGGAGGAGGAGTAGGAATAGGTTATTCCATCCACGCAGGAGTAGTTGTGTGTGCTGATGGAACAAAGGAGAC
AGATTTGAGAATTGAAAGGGTTCTGACAGGGGATCCAGGTCTTGGGATAGTAAGACACGCCGATGCAGGATATGAAATAG
CAATTAAGACTGCAAAAGAAAAGGGAATAAAAATGCCTATGCTTAAATGA

Upstream 100 bases:

>100_bases
AATGTTTTTTTAAAATGTATAAATATTAGCAGGATTTTTGAGAGTCTAAATAGAATAATACTATAAAGCTTTATAGAAAC
AAGAACATGGGGGGATTTTA

Downstream 100 bases:

>100_bases
ATTTGAAAGGGCGTGGGAGAAAGATGAATCAGATAATTGAATGTGTGCCCAATGTGAGCGAAGGAAGGGATCAGGAAAAG
ATTTCTGAGCTCATAAAAGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSRVVRAPRGTELHCKNWQIEAPYRMIMNNLDPEVAEDPANLIVYGGAGKAARNWEAFDKILESLENLEEDETLLVQSGK
PVGIFKTHEMAPRVLISNAMLVPKWANWETFWDLEAKGLTMYGQMTAGSWIYIGSQGIVEGTFETFAALAKKHFDGSLKG
KFVLSAGLGGMGGAQPLAITMLDGACLIVEVDRNRIKRRLETKYLDVMAEDLDEALGMVMKAKEEGRALSVGLVGNAADV
HPELVRRGIIPDVVTDQTSAHDPLNGYVPNGMTLDEAIALRKSNPEEYIKRAKKAMAEHVLAMLEMQKRGAIVFDYGNNI
RRMAYDEGVKDAFNIPSYVPEYIRDLFCEGKGPFRWVALSGDPEDIYKTDQKVLELFPDDPILNRWIRLARERVKFQGLP
ARICWLGYGQRAEFGLAINEMVRKGELKAPIVIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNTASGATWVS
VHHGGGVGIGYSIHAGVVVCADGTKETDLRIERVLTGDPGLGIVRHADAGYEIAIKTAKEKGIKMPMLK

Sequences:

>Translated_549_residues
MSRVVRAPRGTELHCKNWQIEAPYRMIMNNLDPEVAEDPANLIVYGGAGKAARNWEAFDKILESLENLEEDETLLVQSGK
PVGIFKTHEMAPRVLISNAMLVPKWANWETFWDLEAKGLTMYGQMTAGSWIYIGSQGIVEGTFETFAALAKKHFDGSLKG
KFVLSAGLGGMGGAQPLAITMLDGACLIVEVDRNRIKRRLETKYLDVMAEDLDEALGMVMKAKEEGRALSVGLVGNAADV
HPELVRRGIIPDVVTDQTSAHDPLNGYVPNGMTLDEAIALRKSNPEEYIKRAKKAMAEHVLAMLEMQKRGAIVFDYGNNI
RRMAYDEGVKDAFNIPSYVPEYIRDLFCEGKGPFRWVALSGDPEDIYKTDQKVLELFPDDPILNRWIRLARERVKFQGLP
ARICWLGYGQRAEFGLAINEMVRKGELKAPIVIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNTASGATWVS
VHHGGGVGIGYSIHAGVVVCADGTKETDLRIERVLTGDPGLGIVRHADAGYEIAIKTAKEKGIKMPMLK
>Mature_548_residues
SRVVRAPRGTELHCKNWQIEAPYRMIMNNLDPEVAEDPANLIVYGGAGKAARNWEAFDKILESLENLEEDETLLVQSGKP
VGIFKTHEMAPRVLISNAMLVPKWANWETFWDLEAKGLTMYGQMTAGSWIYIGSQGIVEGTFETFAALAKKHFDGSLKGK
FVLSAGLGGMGGAQPLAITMLDGACLIVEVDRNRIKRRLETKYLDVMAEDLDEALGMVMKAKEEGRALSVGLVGNAADVH
PELVRRGIIPDVVTDQTSAHDPLNGYVPNGMTLDEAIALRKSNPEEYIKRAKKAMAEHVLAMLEMQKRGAIVFDYGNNIR
RMAYDEGVKDAFNIPSYVPEYIRDLFCEGKGPFRWVALSGDPEDIYKTDQKVLELFPDDPILNRWIRLARERVKFQGLPA
RICWLGYGQRAEFGLAINEMVRKGELKAPIVIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNTASGATWVSV
HHGGGVGIGYSIHAGVVVCADGTKETDLRIERVLTGDPGLGIVRHADAGYEIAIKTAKEKGIKMPMLK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=35.9570661896243, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI260306182, Length=619, Percent_Identity=33.1179321486268, Blast_Score=307, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI71997891, Length=553, Percent_Identity=35.0813743218806, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60578; Mature: 60447

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVVRAPRGTELHCKNWQIEAPYRMIMNNLDPEVAEDPANLIVYGGAGKAARNWEAFDK
CCCCCCCCCCCEEEECCEEECCCHHHHHHCCCCHHHCCCCCEEEECCCCCCCCCHHHHHH
ILESLENLEEDETLLVQSGKPVGIFKTHEMAPRVLISNAMLVPKWANWETFWDLEAKGLT
HHHHHHCCCCCCEEEEECCCCEEEEECHHHCCHHHHCCCEEECCCCCCCEEEEECCCCEE
MYGQMTAGSWIYIGSQGIVEGTFETFAALAKKHFDGSLKGKFVLSAGLGGMGGAQPLAIT
EEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEE
MLDGACLIVEVDRNRIKRRLETKYLDVMAEDLDEALGMVMKAKEEGRALSVGLVGNAADV
EECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
HPELVRRGIIPDVVTDQTSAHDPLNGYVPNGMTLDEAIALRKSNPEEYIKRAKKAMAEHV
CHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAMLEMQKRGAIVFDYGNNIRRMAYDEGVKDAFNIPSYVPEYIRDLFCEGKGPFRWVALS
HHHHHHHHCCCEEEECCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC
GDPEDIYKTDQKVLELFPDDPILNRWIRLARERVKFQGLPARICWLGYGQRAEFGLAINE
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
MVRKGELKAPIVIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNTASGATWVS
HHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
VHHGGGVGIGYSIHAGVVVCADGTKETDLRIERVLTGDPGLGIVRHADAGYEIAIKTAKE
EECCCCEEECEEEECCEEEEECCCCCCCEEEEEEEECCCCCCEEEECCCCEEEEEEECHH
KGIKMPMLK
CCCCCCCCC
>Mature Secondary Structure 
SRVVRAPRGTELHCKNWQIEAPYRMIMNNLDPEVAEDPANLIVYGGAGKAARNWEAFDK
CCCCCCCCCCEEEECCEEECCCHHHHHHCCCCHHHCCCCCEEEECCCCCCCCCHHHHHH
ILESLENLEEDETLLVQSGKPVGIFKTHEMAPRVLISNAMLVPKWANWETFWDLEAKGLT
HHHHHHCCCCCCEEEEECCCCEEEEECHHHCCHHHHCCCEEECCCCCCCEEEEECCCCEE
MYGQMTAGSWIYIGSQGIVEGTFETFAALAKKHFDGSLKGKFVLSAGLGGMGGAQPLAIT
EEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEE
MLDGACLIVEVDRNRIKRRLETKYLDVMAEDLDEALGMVMKAKEEGRALSVGLVGNAADV
EECCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
HPELVRRGIIPDVVTDQTSAHDPLNGYVPNGMTLDEAIALRKSNPEEYIKRAKKAMAEHV
CHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAMLEMQKRGAIVFDYGNNIRRMAYDEGVKDAFNIPSYVPEYIRDLFCEGKGPFRWVALS
HHHHHHHHCCCEEEECCCCCCHHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEC
GDPEDIYKTDQKVLELFPDDPILNRWIRLARERVKFQGLPARICWLGYGQRAEFGLAINE
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
MVRKGELKAPIVIGRDHHDTGSVASPYRETEAMKDGSDAIADWPILNALLNTASGATWVS
HHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEE
VHHGGGVGIGYSIHAGVVVCADGTKETDLRIERVLTGDPGLGIVRHADAGYEIAIKTAKE
EECCCCEEECEEEECCEEEEECCCCCCCEEEEEEEECCCCCCEEEECCCCEEEEEEECHH
KGIKMPMLK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA