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The map label for this gene is HisC

Identifier: 20806892

GI number: 20806892

Start: 404209

End: 405312

Strand: Direct

Name: HisC

Synonym: TTE0380

Alternate gene names: 20806892

Gene position: 404209-405312 (Clockwise)

Preceding gene: 20806891

Following gene: 20806893

Centisome position: 15.03

GC content: 38.13

Gene sequence:

>1104_bases
GTGAAAGAAGGTGAGAAAATGAAGCCCTATGAGCACGGCGGAAATATCTATGATTATCAAGGAAATCTGATAGATTTTAG
TTCAAATATAAATCCTCTCGGACCTCCTGAGTGGATTTGGGAAGCCATAAAAGAAGTAGATTTATCCAGGTATCCGGATA
TAAAGTATAGAAGGCTCAAAGAAGCTATAGCAGAGTATGTCGGCTGCGATAGAGAAAATATAATTGTCGGAAATGGTGCA
GCAGAGCTTATACATCTCTTTGCCAGAGCTTTTAAGCTGAAAAAACCTCTTATTCCCTCCCCTTCTTTTCTGGAGTATGA
AAGGGCTGTAAAGCTAAACGGGGGAGAACCTGTATACCTTAAGTTGGAGGAGGAAGAAGGGTTTAGGGTAAATTTTGCAA
AAGTGATTTCAAAAATAGAGGAGGCAGATGGCTTGATTTTAGGCAATCCCAATAATCCTACAGGACAGGGCATTATAAGG
GAAGAGATAGGTATATTGCTTAAAAAGGCGGAACTTATGAATATACCGGTTTTGATAGATGAAGCTTTTATAGAATTTAT
GAAGGACTACAAAAAATATGAGGCGCTTCCTCTTGTTAAAAAGCACGACAAACTTTTTGTTGTAAGGGCCGTCACAAAAT
TTTTTGGAATGCCGGGAATAAGGTTGGGATATGGAATTGGCAGCCCTTCTTTAATACAAAAGTTAGAGGAATACAAAGAA
CCGTGGACAGTAAATGCCTTTGCCGAAGCTGTTGGAAGATGGCTTTTTAAAGACAGAGAATATATAGAAAAAACCAGAGA
GTACGTAAATGCTGAAATAGAGCACATGCTCTTTTCACTAAGGACAATAGATTATTTAGTAGCTTTTGATACAAAAGTAA
ACTTTATTCTCCTCAAATTAAAGGCAGGTACTGTAGACGAAGTAAAAGAGAAGCTATTGAAAAAGGGGATTCTTATAAGA
GATGCCTCTAATTTCAGGTATCTTGACAAGAGATTTTTCAGAGTGGCTGTAAAAAGAAGGGAGGACAATATGTGCCTTAT
AGAGGCTTTAAGAGGATTGTACGAAGAAGGTGTCATGCCAGATAAAGAGAGGGTCGTAGTGTAA

Upstream 100 bases:

>100_bases
CAGGACCCGCCACCTGCTGCCTTGTAGTTTACAGAGAAGAAGATACAGACTTTATAAAGGCTATAACAGACAAGCCTTTT
ACGCATGTAGGCATCATAGA

Downstream 100 bases:

>100_bases
TGGGATTGATAATGGTAACAGGCGGTGCCAGGTCAGGAAAAAGTGAATTTGCAGAAAAATTGGCTTATGAAAGGGGGAAA
GATGAAGTTTTATATATAGC

Product: histidinol-phosphate aminotransferase/tyrosine aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKEGEKMKPYEHGGNIYDYQGNLIDFSSNINPLGPPEWIWEAIKEVDLSRYPDIKYRRLKEAIAEYVGCDRENIIVGNGA
AELIHLFARAFKLKKPLIPSPSFLEYERAVKLNGGEPVYLKLEEEEGFRVNFAKVISKIEEADGLILGNPNNPTGQGIIR
EEIGILLKKAELMNIPVLIDEAFIEFMKDYKKYEALPLVKKHDKLFVVRAVTKFFGMPGIRLGYGIGSPSLIQKLEEYKE
PWTVNAFAEAVGRWLFKDREYIEKTREYVNAEIEHMLFSLRTIDYLVAFDTKVNFILLKLKAGTVDEVKEKLLKKGILIR
DASNFRYLDKRFFRVAVKRREDNMCLIEALRGLYEEGVMPDKERVVV

Sequences:

>Translated_367_residues
MKEGEKMKPYEHGGNIYDYQGNLIDFSSNINPLGPPEWIWEAIKEVDLSRYPDIKYRRLKEAIAEYVGCDRENIIVGNGA
AELIHLFARAFKLKKPLIPSPSFLEYERAVKLNGGEPVYLKLEEEEGFRVNFAKVISKIEEADGLILGNPNNPTGQGIIR
EEIGILLKKAELMNIPVLIDEAFIEFMKDYKKYEALPLVKKHDKLFVVRAVTKFFGMPGIRLGYGIGSPSLIQKLEEYKE
PWTVNAFAEAVGRWLFKDREYIEKTREYVNAEIEHMLFSLRTIDYLVAFDTKVNFILLKLKAGTVDEVKEKLLKKGILIR
DASNFRYLDKRFFRVAVKRREDNMCLIEALRGLYEEGVMPDKERVVV
>Mature_367_residues
MKEGEKMKPYEHGGNIYDYQGNLIDFSSNINPLGPPEWIWEAIKEVDLSRYPDIKYRRLKEAIAEYVGCDRENIIVGNGA
AELIHLFARAFKLKKPLIPSPSFLEYERAVKLNGGEPVYLKLEEEEGFRVNFAKVISKIEEADGLILGNPNNPTGQGIIR
EEIGILLKKAELMNIPVLIDEAFIEFMKDYKKYEALPLVKKHDKLFVVRAVTKFFGMPGIRLGYGIGSPSLIQKLEEYKE
PWTVNAFAEAVGRWLFKDREYIEKTREYVNAEIEHMLFSLRTIDYLVAFDTKVNFILLKLKAGTVDEVKEKLLKKGILIR
DASNFRYLDKRFFRVAVKRREDNMCLIEALRGLYEEGVMPDKERVVV

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=320, Percent_Identity=27.1875, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=374, Percent_Identity=25.668449197861, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBD_THETN (Q8R5U4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622063.1
- ProteinModelPortal:   Q8R5U4
- GeneID:   997010
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0380
- NMPDR:   fig|273068.3.peg.344
- HOGENOM:   HBG646350
- OMA:   SEYEDAL
- ProtClustDB:   CLSK900755
- BioCyc:   TTEN273068:TTE0380-MONOMER
- BRENDA:   4.1.1.81
- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01140

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.81

Molecular weight: Translated: 42397; Mature: 42397

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGEKMKPYEHGGNIYDYQGNLIDFSSNINPLGPPEWIWEAIKEVDLSRYPDIKYRRLK
CCCCCCCCCHHCCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHCCHHCCCCHHHHHHH
EAIAEYVGCDRENIIVGNGAAELIHLFARAFKLKKPLIPSPSFLEYERAVKLNGGEPVYL
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEECCCCEEEE
KLEEEEGFRVNFAKVISKIEEADGLILGNPNNPTGQGIIREEIGILLKKAELMNIPVLID
EEECCCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EAFIEFMKDYKKYEALPLVKKHDKLFVVRAVTKFFGMPGIRLGYGIGSPSLIQKLEEYKE
HHHHHHHHHHHHHHCCCCHHCCCCEEHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCC
PWTVNAFAEAVGRWLFKDREYIEKTREYVNAEIEHMLFSLRTIDYLVAFDTKVNFILLKL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEE
KAGTVDEVKEKLLKKGILIRDASNFRYLDKRFFRVAVKRREDNMCLIEALRGLYEEGVMP
CCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DKERVVV
CCCCCCC
>Mature Secondary Structure
MKEGEKMKPYEHGGNIYDYQGNLIDFSSNINPLGPPEWIWEAIKEVDLSRYPDIKYRRLK
CCCCCCCCCHHCCCCEEEECCCEEEECCCCCCCCCHHHHHHHHHHCCHHCCCCHHHHHHH
EAIAEYVGCDRENIIVGNGAAELIHLFARAFKLKKPLIPSPSFLEYERAVKLNGGEPVYL
HHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEECCCCEEEE
KLEEEEGFRVNFAKVISKIEEADGLILGNPNNPTGQGIIREEIGILLKKAELMNIPVLID
EEECCCCCEEEHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHH
EAFIEFMKDYKKYEALPLVKKHDKLFVVRAVTKFFGMPGIRLGYGIGSPSLIQKLEEYKE
HHHHHHHHHHHHHHCCCCHHCCCCEEHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCC
PWTVNAFAEAVGRWLFKDREYIEKTREYVNAEIEHMLFSLRTIDYLVAFDTKVNFILLKL
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEE
KAGTVDEVKEKLLKKGILIRDASNFRYLDKRFFRVAVKRREDNMCLIEALRGLYEEGVMP
CCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
DKERVVV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336